Structure and function of Cu(I)- and Zn(II)-ATPases

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Oleg Sitsel
  • ,
  • Christina Grønberg, Københavns Universitet, Danmark
  • Henriette Autzen, Københavns Universitet, Danmark
  • Kaituo Wang, Københavns Universitet
  • ,
  • Gabriele Meloni
  • ,
  • Poul Nissen
  • Pontus Gourdon, Københavns Universitet, Lund University, Danmark

Copper and zinc are micronutrients essential for the function of many enzymes while also toxic at elevated concentrations. Cu(I)- and Zn(II)-transporting P-type ATPases of subclass 1B are of key importance for homeostasis of these transition metals, allowing ion transport across cellular membranes at the expense of ATP. Recent biochemical studies and crystal structures have significantly increased the understanding of the transport mechanisms of these proteins, but many details about their structure and function remains elusive. Here we compare the Cu(I)- and Zn(II)-ATPases, scrutinizing the molecular differences that allow transport of these two distinct metal types, and discuss possible future directions of research in the field.

Sider (fra-til)5673-5683
Antal sider11
StatusUdgivet - 1 jul. 2015

Se relationer på Aarhus Universitet Citationsformater

ID: 90102924