Structural studies of the Vps10p-domain receptors and their complexes

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

  • Dovile Januliene, Danmark
ForlagAarhus University, Faculty of Science and Technology
StatusUdgivet - 20 feb. 2015

Note vedr. afhandling

During her studies, Dovilė Janulienė, investigated proteins in the brain, associated with various diseases, including Frontotemporal lobar degeneration, which is one of the most common types of dementia after Alzheimer’s disease. The main cause of this dementia is the lack of a certain protein, called progranulin, in the brain. The levels of progranulin are controlled by its receptor, called Sortilin. Dovilė Janulienė studied how the two proteins bind each other and what is the structure of the complex. Her findings explain the molecular basis of the interaction between Sortilin and progranulin and provide structural insights for drug design.

The PhD degree was completed at the Center for Structural Biology, Department of Molecular Biology and Genetics, Science and Technology, Aarhus University

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