Structural studies of the gastric proton pump and the sarcoplasmic reticulum calcium pump

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

  • Ingrid Dach, Danmark
OriginalsprogEngelsk
Antal sider152
StatusUdgivet - 4 nov. 2013

Note vedr. afhandling

During her PhD studies, Ingrid Dach used a variety of biophysical methods to investigate two proteins involved in the transport of ions across biological membranes: the gastric proton pump responsible for the maintenance of an acidic environment in the stomach required for digestion, and the sarcoplasmic reticulum calcium pump whose proper function is essential for many vital processes within all cells.

The new research findings contribute to the understanding of the relationship between the structure and function of the gastric proton pump, and provide information about the structural mechanisms of inhibition of the calcium pump by a compound that has been designed as a novel prodrug for the treatment of advanced prostate cancer.

The PhD degree was completed at the Centre for Membrane Pumps in Cells and Disease (PUMPkin), Department of Molecular Biology and Genetics, Science and Technology, Aarhus University.

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