Structural rationale behind template recognition and exponential RNA amplification by the Qβ replicase complex

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

Antal sider217
Rekvirerende organGraduate School of Science and Technology
StatusUdgivet - 18 jun. 2015

Note vedr. afhandling

Email Facebook LinkedIn During her studies, cand.scient. Heidi Gytz Olesen has researched the mechanism behind virus multiplication in the course of an infection. Special interest has been directed towards the copying of viral genetic material, which is a prerequisite for the formation of new virus particles. During this copying event, the viral proteins hijack proteins of the host cell important for normal cell maintenance and exploit these. This interplay is important for continuation of the infection cycle and thus presents a possible target in the fight against these pathogens.

As a model system, Heidi has investigated a bacteriophage, which is a virus capable of infecting bacteria, but not humans. By use of x-ray crystallography she has obtained three-dimensional images of proteins, which reveal how a virus protein cooperates with proteins of the infected cell for multiplication of the viral genetic material.

The PhD degree was completed at Department of Molecular Biology and Genetics, Science and Technology, Aarhus Universitet.


  • Q beta Replicase, Ribosomal Protein S1, RNA virus

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