Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins

Mikael B L Winkler; Rune T Kidmose; Maria Szomek; Katja Thaysen; Shaun Rawson; Stephen P Muench; Daniel Wüstner; Bjørn Panyella Pedersen

doi:10.1016/j.cell.2019.08.038

Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins

Mikael B L Winkler, Rune T Kidmose, Maria Szomek, Katja Thaysen, Shaun Rawson, Stephen P Muench, Daniel Wüstner, Bjørn Panyella Pedersen

Aarhus Institute of Advanced Studies

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

97 Citationer (Scopus)

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Abstract

Structural and functional analyses of the yeast Niemann-Pick type C proteins illustrate how sterols access and integrate into vacuolar/lysosomal membranes.

Originalsprog	Engelsk
Artikelnummer	e18
Tidsskrift	Cell
Vol/bind	179
Nummer	2
Sider (fra-til)	485-497
ISSN	0092-8674
DOI	https://doi.org/10.1016/j.cell.2019.08.038
Status	Udgivet - 3 okt. 2019

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10.1016/j.cell.2019.08.038

final_merged_accepted_manuscript_for_open_access_12mo_embargoAccepteret manuskript, 48,1 MBLicens: CC BY-NC-ND

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title = "Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins",

abstract = "Structural and functional analyses of the yeast Niemann-Pick type C proteins illustrate how sterols access and integrate into vacuolar/lysosomal membranes.",

keywords = "NCR1, NPC1, NPC2, Niemann-Pick type C proteins, X-ray crystallography, cryo-EM, lipid trafficking, sterol homeostasis, sterol membrane integration",

author = "Winkler, {Mikael B L} and Kidmose, {Rune T} and Maria Szomek and Katja Thaysen and Shaun Rawson and Muench, {Stephen P} and Daniel W{\"u}stner and Pedersen, {Bj{\o}rn Panyella}",

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doi = "10.1016/j.cell.2019.08.038",

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AU - Winkler, Mikael B L

AU - Kidmose, Rune T

AU - Szomek, Maria

AU - Thaysen, Katja

AU - Rawson, Shaun

AU - Muench, Stephen P

AU - Wüstner, Daniel

AU - Pedersen, Bjørn Panyella

PY - 2019/10/3

Y1 - 2019/10/3

N2 - Structural and functional analyses of the yeast Niemann-Pick type C proteins illustrate how sterols access and integrate into vacuolar/lysosomal membranes.

AB - Structural and functional analyses of the yeast Niemann-Pick type C proteins illustrate how sterols access and integrate into vacuolar/lysosomal membranes.

KW - NCR1

KW - NPC1

KW - NPC2

KW - Niemann-Pick type C proteins

KW - X-ray crystallography

KW - cryo-EM

KW - lipid trafficking

KW - sterol homeostasis

KW - sterol membrane integration

UR - http://www.scopus.com/inward/record.url?scp=85072735334&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2019.08.038

DO - 10.1016/j.cell.2019.08.038

M3 - Journal article

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SN - 0092-8674

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SP - 485

EP - 497

JO - Cell

JF - Cell

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ER -

Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins

Abstract

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