@article{4ee11a5ba1614f35a10661699ee4bc8c,
title = "Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires",
abstract = "By studying the processing of pri-miR-9 family, Bofill-De Ros et al. demonstrate that the tertiary structure of pri-miRNA triggers alternative biogenesis. Drosha cleaves pri-miR-9-1 at an additional site because of its distorted and flexible lower stem, generating a 5′ isomiR that regulates a distinct set of genes in low-grade glioma.",
keywords = "Drosha, isomiRs, microprocessor, miR-9, paralogs, primary miRNA, RNA structure",
author = "{Bofill-De Ros}, Xavier and Kasprzak, {Wojciech K.} and Yuba Bhandari and Lixin Fan and Quinn Cavanaugh and Minjie Jiang and Lisheng Dai and Acong Yang and Shao, {Tie Juan} and Shapiro, {Bruce A.} and Wang, {Yun Xing} and Shuo Gu",
note = "Publisher Copyright: {\textcopyright} 2018",
year = "2019",
month = jan,
day = "8",
doi = "10.1016/j.celrep.2018.12.054",
language = "English",
volume = "26",
pages = "447--459.e4",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "2",
}