Strontium functionalized scaffold for bone tissue engineering

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  • Rahul D. Prabha, Odense University Hospital, SDU, Amrita School of Dentistry
  • ,
  • Bindu P. Nair, Sree Chitra Tirunal Institute for Medical Sciences and Technology
  • ,
  • Nicholas Ditzel, Odense University Hospital, SDU
  • ,
  • Jorgen Kjems
  • Prabha D. Nair, Sree Chitra Tirunal Institute for Medical Sciences and Technology
  • ,
  • Moustapha Kassem, Odense University Hospital, SDU

Drug functionalized scaffolds are currently being employed to improve local delivery of osteoprotective drugs with the aim of reducing their loading dose as well as unwanted systemic complications. In this study we tested a poly-(ε) caprolactone (PCL)–laponite–strontium ranelate (SRA) composite scaffold (PLS3) for its abilities to support growth and osteogenic differentiation of human marrow derived stromal stem cells (hMSC). The in vitro experiments showed the PLS3 scaffold supported cell growth and osteogenic differentiation. The in vivo implantation of hMSC seeded PLS3 scaffold in immunocompromised mice revealed vascularized ectopic bone formation. PLS3 scaffolds can be useful in bone regenerative applications in the fields of orthopaedics and dentistry.

OriginalsprogEngelsk
TidsskriftMaterials Science and Engineering C: Biomimetic Materials, Sensors and Systems
Vol/bind94
Sider (fra-til)509-515
Antal sider7
ISSN0928-4931
DOI
StatusUdgivet - jan. 2019

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