Stringent or nonstringent complete remission and prognosis in acute myeloid leukemia: a Danish population-based study

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  • Andreas K Øvlisen, Aalborg Universitet, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
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  • Anders Oest, Aalborg Universitet, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
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  • Mette D Bendtsen, Aalborg Universitet, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
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  • John Bæch, Department of Clinical Immunology, Aalborg University Hospital
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  • Preben Johansen, Department of Haematopathology, Aalborg University Hospital, Aalborg, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg
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  • Line S Lynggaard
  • Ingolf Mølle
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  • Thomas B Mortensen, Department of Haematology, Odense University Hospital, Odense, Denmark.
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  • Duruta Weber, Department of Haematology, Odense University Hospital, Odense, Denmark.
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  • Gideon Ertner, Department of Haematology, Herlev Hospital, Herlev
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  • Claudia Schöllkopf, Department of Haematology, Herlev Hospital, Herlev
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  • Jesper Q Thomassen, Københavns Universitet
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  • Ove Juul Nielsen, Department of Haematology, Rigshospitalet, Copenhagen
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  • Lene Sofie Granfeldt Østgård
  • Martin Bøgsted, Aalborg Universitet, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Clinical Cancer Research Center, Aalborg University Hospital, Aalborg
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  • Karen Dybkær, Aalborg Universitet, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Clinical Cancer Research Center, Aalborg University Hospital, Aalborg
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  • Hans E Johnsen, Aalborg Universitet, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Clinical Cancer Research Center, Aalborg University Hospital, Aalborg
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  • Marianne T Severinsen, Aalborg Universitet, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Clinical Cancer Research Center, Aalborg University Hospital, Aalborg

Stringent complete remission (sCR) of acute myeloid leukemia is defined as normal hematopoiesis after therapy. Less sCR, including non-sCR, was introduced as insufficient blood platelet, neutrophil, or erythrocyte recovery. These latter characteristics were defined retrospectively as postremission transfusion dependency and were suggested to be of prognostic value. In the present report, we evaluated the prognostic impact of achieving sCR and non-sCR in the Danish National Acute Leukaemia Registry, including 769 patients registered with classical CR (ie, <5% blasts in the postinduction bone marrow analysis). Individual patients were classified as having sCR (n = 360; 46.8%) or non-sCR (n = 409; 53.2%) based on data from our national laboratory and transfusion databases. Survival analysis revealed that patients achieving sCR had superior overall survival (hazard ratio [HR], 1.34; 95% confidence interval [CI], 1.10-1.64) as well as relapse-free survival (HR, 1.25; 95% CI, 1.03-1.51) compared with those with non-sCR after adjusting for covariates. Cox regression analysis regarding the impact of the stringent criteria for blood cell recovery identified these as significant and independent variables. In conclusion, this real-life register study supports the international criteria for response evaluation on prognosis and, most importantly, documents each of the 3 lineage recovery criteria as contributing independently.

OriginalsprogEngelsk
TidsskriftBlood Advances
Vol/bind2
Nummer5
Sider (fra-til)559-564
Antal sider6
ISSN2473-9529
DOI
StatusUdgivet - 13 mar. 2018

Bibliografisk note

© 2018 by The American Society of Hematology.

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