Strain-, sex-, and time-dependent antidepressant-like effects of cannabidiol

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Cannabidiol (CBD) is a non-intoxicating compound extracted from Cannabis sativa, showing antidepressant-like effects in different rodent models. However, inconsistent results have been described depending on the species and the strain used to assess depressive-like behavior. Moreover, only a few studies investigated the effect of CBD in female rodents. Therefore, we aimed to (i) investigate the effects of CBD in two different strains of mice (Swiss and C57BL/6) and a rat model of depression based on selective breeding (Flinders Sensitive and Resistant Lines, FSL and FRL) subjected to tests predictive of antidepressant-like effects and (ii) investigate the influence of sex in the effects of CBD in both mice and rats. CBD induced an antidepressant-like effect in male Swiss but not in female Swiss or C57BL/6 mice in the tail suspension test (TST). In male FSL rats, CBD produced an antidepressant-like effect 1 h post injection. However, in female FSL, CBD induced a bimodal effect, increasing the immobility time at 1 h and decreasing it at 2 h. In conclusion, strain, sex, and administration time affect CBD’s behavioral response to rodents exposed to tests predictive of antidepressant effects.

OriginalsprogEngelsk
Artikelnummer1269
TidsskriftPharmaceuticals
Vol/bind14
Nummer12
ISSN1424-8247
DOI
StatusUdgivet - dec. 2021

Bibliografisk note

Funding Information:
Funding: G.P.S. acknowledges grant support from the São Paulo Research Foundation (FAPESP; Grant numbers 2017/26815-1 and 2018/12119-6) and National Council for Scientific and Technological Development: (CNPq; Grant number 141585/2016-1). M.C.G. is thankful to the CNPq for the fellowship for PIBIC. G.W. is thankful to Independent Research Fund Denmark (grant 8020-00310B), Aarhus University Research Foundation, Denmark (AU-IDEAS initiative (eMOOD)), and EU Horizon 2020 (ExEDE). S.R.L.J. has received funding from the AIAS-COFUND II fellowship program supported by the Marie Skłodowska-Curie actions under the European Union’s Horizon 2020 (Grant agreement number 754513) Aarhus University Research Foundation. S.R.L.J. is thankful to the CNPq for fellowships for productivity in research (304780/2018-9).

Funding Information:
G.P.S. acknowledges grant support from the S?o Paulo Research Foundation (FAPESP; Grant numbers 2017/26815-1 and 2018/12119-6) and National Council for Scientific and Technological Development: (CNPq; Grant number 141585/2016-1). M.C.G. is thankful to the CNPq for the fellowship for PIBIC. G.W. is thankful to Independent Research Fund Denmark (grant 8020-00310B), Aarhus University Research Foundation, Denmark (AU-IDEAS initiative (eMOOD)), and EU Horizon 2020 (ExEDE). S.R.L.J. has received funding from the AIAS-COFUND II fellowship program supported by the Marie Sk?odowska-Curie actions under the European Union?s Horizon 2020 (Grant agreement number 754513) Aarhus University Research Foundation. S.R.L.J. is thankful to the CNPq for fellowships for productivity in research (304780/2018-9).

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© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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