Stable analogues of nojirimycin--synthesis and biological evaluation of nojiristegine and manno-nojiristegine

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Standard

Stable analogues of nojirimycin--synthesis and biological evaluation of nojiristegine and manno-nojiristegine. / Viuff, Agnete H; Besenbacher, Louise M; Kamori, Akiko; Jensen, Mikkel T; Kilian, Mogens; Kato, Atsushi; Jensen, Henrik H.

I: Organic & Biomolecular Chemistry, Bind 13, Nr. 37, 07.10.2015, s. 9637-58.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Viuff, AH, Besenbacher, LM, Kamori, A, Jensen, MT, Kilian, M, Kato, A & Jensen, HH 2015, 'Stable analogues of nojirimycin--synthesis and biological evaluation of nojiristegine and manno-nojiristegine', Organic & Biomolecular Chemistry, bind 13, nr. 37, s. 9637-58. https://doi.org/10.1039/c5ob01281c

APA

Viuff, A. H., Besenbacher, L. M., Kamori, A., Jensen, M. T., Kilian, M., Kato, A., & Jensen, H. H. (2015). Stable analogues of nojirimycin--synthesis and biological evaluation of nojiristegine and manno-nojiristegine. Organic & Biomolecular Chemistry, 13(37), 9637-58. https://doi.org/10.1039/c5ob01281c

CBE

Viuff AH, Besenbacher LM, Kamori A, Jensen MT, Kilian M, Kato A, Jensen HH. 2015. Stable analogues of nojirimycin--synthesis and biological evaluation of nojiristegine and manno-nojiristegine. Organic & Biomolecular Chemistry. 13(37):9637-58. https://doi.org/10.1039/c5ob01281c

MLA

Vancouver

Viuff AH, Besenbacher LM, Kamori A, Jensen MT, Kilian M, Kato A o.a. Stable analogues of nojirimycin--synthesis and biological evaluation of nojiristegine and manno-nojiristegine. Organic & Biomolecular Chemistry. 2015 okt 7;13(37):9637-58. https://doi.org/10.1039/c5ob01281c

Author

Viuff, Agnete H ; Besenbacher, Louise M ; Kamori, Akiko ; Jensen, Mikkel T ; Kilian, Mogens ; Kato, Atsushi ; Jensen, Henrik H. / Stable analogues of nojirimycin--synthesis and biological evaluation of nojiristegine and manno-nojiristegine. I: Organic & Biomolecular Chemistry. 2015 ; Bind 13, Nr. 37. s. 9637-58.

Bibtex

@article{df1f1bfb2156482584a74e36d2025199,
title = "Stable analogues of nojirimycin--synthesis and biological evaluation of nojiristegine and manno-nojiristegine",
abstract = "Two novel iminosugars called nojiristegines, being structural hybrids between nor-tropane alkaloid calystegine and nojirimycins, have been synthesised and found to be stable molecules despite the presence of a hemiaminal functionality. The synthesised iminosugars were evaluated against a panel of glycosidases and the best inhibition (IC50), found against α-glucosidases, was in the micromolar region. The compounds were also evaluated as potential antibiotics but no useful level of activity was observed.",
author = "Viuff, {Agnete H} and Besenbacher, {Louise M} and Akiko Kamori and Jensen, {Mikkel T} and Mogens Kilian and Atsushi Kato and Jensen, {Henrik H}",
year = "2015",
month = oct,
day = "7",
doi = "10.1039/c5ob01281c",
language = "English",
volume = "13",
pages = "9637--58",
journal = "Organic & Biomolecular Chemistry",
issn = "1477-0520",
publisher = "ROYAL SOC CHEMISTRY",
number = "37",

}

RIS

TY - JOUR

T1 - Stable analogues of nojirimycin--synthesis and biological evaluation of nojiristegine and manno-nojiristegine

AU - Viuff, Agnete H

AU - Besenbacher, Louise M

AU - Kamori, Akiko

AU - Jensen, Mikkel T

AU - Kilian, Mogens

AU - Kato, Atsushi

AU - Jensen, Henrik H

PY - 2015/10/7

Y1 - 2015/10/7

N2 - Two novel iminosugars called nojiristegines, being structural hybrids between nor-tropane alkaloid calystegine and nojirimycins, have been synthesised and found to be stable molecules despite the presence of a hemiaminal functionality. The synthesised iminosugars were evaluated against a panel of glycosidases and the best inhibition (IC50), found against α-glucosidases, was in the micromolar region. The compounds were also evaluated as potential antibiotics but no useful level of activity was observed.

AB - Two novel iminosugars called nojiristegines, being structural hybrids between nor-tropane alkaloid calystegine and nojirimycins, have been synthesised and found to be stable molecules despite the presence of a hemiaminal functionality. The synthesised iminosugars were evaluated against a panel of glycosidases and the best inhibition (IC50), found against α-glucosidases, was in the micromolar region. The compounds were also evaluated as potential antibiotics but no useful level of activity was observed.

U2 - 10.1039/c5ob01281c

DO - 10.1039/c5ob01281c

M3 - Journal article

C2 - 26264193

VL - 13

SP - 9637

EP - 9658

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

SN - 1477-0520

IS - 37

ER -