Stable analogues of nojirimycin--synthesis and biological evaluation of nojiristegine and manno-nojiristegine

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  • Agnete H Viuff
  • ,
  • Louise M Besenbacher
  • ,
  • Akiko Kamori, Danmark
  • Mikkel T Jensen
  • ,
  • Mogens Kilian
  • Atsushi Kato
  • ,
  • Henrik H Jensen

Two novel iminosugars called nojiristegines, being structural hybrids between nor-tropane alkaloid calystegine and nojirimycins, have been synthesised and found to be stable molecules despite the presence of a hemiaminal functionality. The synthesised iminosugars were evaluated against a panel of glycosidases and the best inhibition (IC50), found against α-glucosidases, was in the micromolar region. The compounds were also evaluated as potential antibiotics but no useful level of activity was observed.

OriginalsprogEngelsk
TidsskriftOrganic & Biomolecular Chemistry
Vol/bind13
Nummer37
Sider (fra-til)9637-58
Antal sider22
ISSN1477-0520
DOI
StatusUdgivet - 7 okt. 2015

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