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Spider genomes provide insight into composition and evolution of venom and silk
Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
Links
DOI
- Kristian W Sanggaard, Aarhus Universitet, Danmark
- Jesper S Bechsgaard
- Xiaodong Fang, 1] BGI-Tech, BGI-Shenzhen, Shenzhen 518083, China [2] Department of Biology, University of Copenhagen, 2100 Copenhagen, Denmark [3]. ,
- Jinjie Duan
- Thomas F Dyrlund, Danmark
- Vikas Gupta, Danmark
- Xuanting Jiang, BGI-Shenzhen ,
- Ling Cheng, BGI-Shenzhen ,
- Dingding Fan, BGI-Shenzhen ,
- Yue Feng, BGI-Shenzhen ,
- Lijuan Han, BGI-Shenzhen ,
- Zhiyong Huang, BGI-Shenzhen ,
- Zongze Wu, BGI-Shenzhen, Danmark
- Li Liao, BGI-Shenzhen, Danmark
- Virginia Settepani
- Ida B Thøgersen
- Bram Vanthournout, Danmark
- Tobias Wang
- Yabing Zhu, BGI-Shenzhen, Danmark
- Peter Funch
- Jan Johannes Enghild
- Leif Schauser, CLC bio, Silkeborgvej 2, 8000 Aarhus C, Denmark., Danmark
- Stig U Andersen
- Palle Villesen
- Mikkel Heide Schierup
- Trine Bilde
- Jun Wang, Københavns Universitet, King Abdulaziz University, BGI-Shenzhen, Danmark
- Institut for Molekylærbiologi og Genetik - Proteinforskning
- Institut for Biologi - Genetik, økologi og evolution
- Institut for Molekylærbiologi og Genetik - Center for Bioinformatik (BiRC)
- Institut for Datalogi
- Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
- Institut for Biologi - Zoofysiologi
- Arctic Research Centre
- Interdisciplinary Nanoscience Center - INANO-MBG, Gustav Wied 10
- Institut for Molekylærbiologi og Genetik - Plantemolekylærbiologi
- Institut for Klinisk Medicin - Enhed for Bioinformatik
Spiders are ecologically important predators with complex venom and extraordinarily tough silk that enables capture of large prey. Here we present the assembled genome of the social velvet spider and a draft assembly of the tarantula genome that represent two major taxonomic groups of spiders. The spider genomes are large with short exons and long introns, reminiscent of mammalian genomes. Phylogenetic analyses place spiders and ticks as sister groups supporting polyphyly of the Acari. Complex sets of venom and silk genes/proteins are identified. We find that venom genes evolved by sequential duplication, and that the toxic effect of venom is most likely activated by proteases present in the venom. The set of silk genes reveals a highly dynamic gene evolution, new types of silk genes and proteins, and a novel use of aciniform silk. These insights create new opportunities for pharmacological applications of venom and biomaterial applications of silk.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 3765 |
| Tidsskrift | Nature Communications |
| Vol/bind | 5 |
| Antal sider | 11 |
| ISSN | 2041-1723 |
| DOI | |
| Status | Udgivet - 2014 |
Se relationer på Aarhus Universitet Citationsformater
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