Specific incorporation of kinetin into eukaryotic and prokaryotic transfer ribonucleic acid molecules

J. Barciszewski*, D. Otzen, S. I.S. Rattan, B. F.C. Clark

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

5 Citationer (Scopus)

Abstract

We show that kinetin, a non-natural product with strong cytokinin activity, is incorporated into prokaryotic and eukaryotic tRNAs in the exchange reaction catalysed by a putative tRNA-kinetin transglycosylase. We also show that kinetin is specifically incorporated into E. coli tRNA(Tyr) and most probably at position 37. To our knowledge, this is the first report of a nucleic acid base exchange reaction occurring at this position.

OriginalsprogEngelsk
TidsskriftBiochemistry international
Vol/bind28
Nummer5
Sider (fra-til)805-811
Antal sider7
ISSN0158-5231
StatusUdgivet - 1 dec. 1992

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