Spatio-temporal regulation of ADAR editing during development in porcine neural tissues

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Editing by ADAR enzymes is essential for mammalian life. Still, knowledge of the spatio-temporal editing patterns in mammals is limited. By use of 454 amplicon sequencing we examined the editing status of 12 regionally extracted mRNAs from porcine developing brain encompassing a total of 64 putative ADAR editing sites. In total 24 brain tissues, dissected from up to five regions from embryonic gestation day 23, 42, 60, 80, 100 and 115, were examined for editing.
OriginalsprogEngelsk
TidsskriftRNA Biology
Vol/bind9
Nummer8
Sider (fra-til)1054-1065
Antal sider12
ISSN1547-6286
DOI
StatusUdgivet - aug. 2012

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