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SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation

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SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation. / Thomsen, Martin K; Ambroisine, Laurence; Wynn, Sarah; Cheah, Kathryn S E; Foster, Christopher S; Fisher, Gabrielle; Berney, Daniel M; Møller, Henrik; Reuter, Victor E; Scardino, Peter; Cuzick, Jack; Ragavan, Narasimhan; Singh, Paras B; Martin, Francis L; Butler, Christopher M; Cooper, Colin S.; Swain, Amanda; Transatlantic Prostate Group.

I: Cancer research, Bind 70, Nr. 3, 01.02.2010, s. 979-87.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Thomsen, MK, Ambroisine, L, Wynn, S, Cheah, KSE, Foster, CS, Fisher, G, Berney, DM, Møller, H, Reuter, VE, Scardino, P, Cuzick, J, Ragavan, N, Singh, PB, Martin, FL, Butler, CM, Cooper, CS, Swain, A & Transatlantic Prostate Group 2010, 'SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation', Cancer research, bind 70, nr. 3, s. 979-87. https://doi.org/10.1158/0008-5472.CAN-09-2370

APA

Thomsen, M. K., Ambroisine, L., Wynn, S., Cheah, K. S. E., Foster, C. S., Fisher, G., Berney, D. M., Møller, H., Reuter, V. E., Scardino, P., Cuzick, J., Ragavan, N., Singh, P. B., Martin, F. L., Butler, C. M., Cooper, C. S., Swain, A., & Transatlantic Prostate Group (2010). SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation. Cancer research, 70(3), 979-87. https://doi.org/10.1158/0008-5472.CAN-09-2370

CBE

Thomsen MK, Ambroisine L, Wynn S, Cheah KSE, Foster CS, Fisher G, Berney DM, Møller H, Reuter VE, Scardino P, Cuzick J, Ragavan N, Singh PB, Martin FL, Butler CM, Cooper CS, Swain A, Transatlantic Prostate Group. 2010. SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation. Cancer research. 70(3):979-87. https://doi.org/10.1158/0008-5472.CAN-09-2370

MLA

Vancouver

Author

Thomsen, Martin K ; Ambroisine, Laurence ; Wynn, Sarah ; Cheah, Kathryn S E ; Foster, Christopher S ; Fisher, Gabrielle ; Berney, Daniel M ; Møller, Henrik ; Reuter, Victor E ; Scardino, Peter ; Cuzick, Jack ; Ragavan, Narasimhan ; Singh, Paras B ; Martin, Francis L ; Butler, Christopher M ; Cooper, Colin S. ; Swain, Amanda ; Transatlantic Prostate Group. / SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation. I: Cancer research. 2010 ; Bind 70, Nr. 3. s. 979-87.

Bibtex

@article{177bdd23e8b34bbba65dd10ca3edc6bd,
title = "SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation",
abstract = "Dysregulation of tissue development pathways can contribute to cancer initiation and progression. In murine embryonic prostate epithelia, the transcription factor SOX9 is required for proper prostate development. In this study, we examined a role for SOX9 in prostate cancer in mouse and human. In Pten and Nkx3.1 mutant mice, cells with increased levels of SOX9 appeared within prostate epithelia at early stages of neoplasia, and higher expression correlated with progression at all stages of disease. In transgenic mice, SOX9 overexpression in prostate epithelia increased cell proliferation without inducing hyperplasia. In transgenic mice that were also heterozygous for mutant Pten, SOX9 overexpression quickened the induction of high-grade prostate intraepithelial neoplasia. In contrast, Sox9 attenuation led to a decrease proliferating prostate epithelia cells in normal and homozygous Pten mutant mice with prostate neoplasia. Analysis of a cohort of 880 human prostate cancer samples showed that SOX9 expression was associated with increasing Gleason grades and higher Ki67 staining. Our findings identify SOX9 as part of a developmental pathway that is reactivated in prostate neoplasia where it promotes tumor cell proliferation.",
keywords = "Adult, Animals, Cell Proliferation, Epithelium, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Homeodomain Proteins, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Ki-67 Antigen, Male, Mice, Mice, Knockout, Mice, Transgenic, PTEN Phosphohydrolase, Prostate, Prostatic Neoplasms, Reverse Transcriptase Polymerase Chain Reaction, SOX9 Transcription Factor, Tissue Array Analysis, Transcription Factors, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",
author = "Thomsen, {Martin K} and Laurence Ambroisine and Sarah Wynn and Cheah, {Kathryn S E} and Foster, {Christopher S} and Gabrielle Fisher and Berney, {Daniel M} and Henrik M{\o}ller and Reuter, {Victor E} and Peter Scardino and Jack Cuzick and Narasimhan Ragavan and Singh, {Paras B} and Martin, {Francis L} and Butler, {Christopher M} and Cooper, {Colin S.} and Amanda Swain and {Transatlantic Prostate Group}",
year = "2010",
month = feb,
day = "1",
doi = "10.1158/0008-5472.CAN-09-2370",
language = "English",
volume = "70",
pages = "979--87",
journal = "Cancer research",
issn = "1538-7445",
publisher = "American Association for Cancer Research Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation

AU - Thomsen, Martin K

AU - Ambroisine, Laurence

AU - Wynn, Sarah

AU - Cheah, Kathryn S E

AU - Foster, Christopher S

AU - Fisher, Gabrielle

AU - Berney, Daniel M

AU - Møller, Henrik

AU - Reuter, Victor E

AU - Scardino, Peter

AU - Cuzick, Jack

AU - Ragavan, Narasimhan

AU - Singh, Paras B

AU - Martin, Francis L

AU - Butler, Christopher M

AU - Cooper, Colin S.

AU - Swain, Amanda

AU - Transatlantic Prostate Group

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Dysregulation of tissue development pathways can contribute to cancer initiation and progression. In murine embryonic prostate epithelia, the transcription factor SOX9 is required for proper prostate development. In this study, we examined a role for SOX9 in prostate cancer in mouse and human. In Pten and Nkx3.1 mutant mice, cells with increased levels of SOX9 appeared within prostate epithelia at early stages of neoplasia, and higher expression correlated with progression at all stages of disease. In transgenic mice, SOX9 overexpression in prostate epithelia increased cell proliferation without inducing hyperplasia. In transgenic mice that were also heterozygous for mutant Pten, SOX9 overexpression quickened the induction of high-grade prostate intraepithelial neoplasia. In contrast, Sox9 attenuation led to a decrease proliferating prostate epithelia cells in normal and homozygous Pten mutant mice with prostate neoplasia. Analysis of a cohort of 880 human prostate cancer samples showed that SOX9 expression was associated with increasing Gleason grades and higher Ki67 staining. Our findings identify SOX9 as part of a developmental pathway that is reactivated in prostate neoplasia where it promotes tumor cell proliferation.

AB - Dysregulation of tissue development pathways can contribute to cancer initiation and progression. In murine embryonic prostate epithelia, the transcription factor SOX9 is required for proper prostate development. In this study, we examined a role for SOX9 in prostate cancer in mouse and human. In Pten and Nkx3.1 mutant mice, cells with increased levels of SOX9 appeared within prostate epithelia at early stages of neoplasia, and higher expression correlated with progression at all stages of disease. In transgenic mice, SOX9 overexpression in prostate epithelia increased cell proliferation without inducing hyperplasia. In transgenic mice that were also heterozygous for mutant Pten, SOX9 overexpression quickened the induction of high-grade prostate intraepithelial neoplasia. In contrast, Sox9 attenuation led to a decrease proliferating prostate epithelia cells in normal and homozygous Pten mutant mice with prostate neoplasia. Analysis of a cohort of 880 human prostate cancer samples showed that SOX9 expression was associated with increasing Gleason grades and higher Ki67 staining. Our findings identify SOX9 as part of a developmental pathway that is reactivated in prostate neoplasia where it promotes tumor cell proliferation.

KW - Adult

KW - Animals

KW - Cell Proliferation

KW - Epithelium

KW - Gene Expression Profiling

KW - Gene Expression Regulation, Neoplastic

KW - Homeodomain Proteins

KW - Humans

KW - Immunohistochemistry

KW - Kaplan-Meier Estimate

KW - Ki-67 Antigen

KW - Male

KW - Mice

KW - Mice, Knockout

KW - Mice, Transgenic

KW - PTEN Phosphohydrolase

KW - Prostate

KW - Prostatic Neoplasms

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - SOX9 Transcription Factor

KW - Tissue Array Analysis

KW - Transcription Factors

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1158/0008-5472.CAN-09-2370

DO - 10.1158/0008-5472.CAN-09-2370

M3 - Journal article

C2 - 20103652

VL - 70

SP - 979

EP - 987

JO - Cancer research

JF - Cancer research

SN - 1538-7445

IS - 3

ER -