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Abstract
Recent studies have identified SOX11 as a novel diagnostic marker for mantle cell lymphoma (MCL). We quantified SOX11 by a truly mRNA specific qPCR assay in longitudinal peripheral blood samples from 20 patients and evidenced a close relationship of SOX11 expression and clinical status of the patients. In eight patient courses we validated the expression of SOX11 using t(11;14) and demonstrated positive correlation of SOX11 and t(11;14) levels. To the best of our knowledge this is the first report stating that quantification of SOX11 can be used as an minimal residual disease marker equal to the key translocation t(11;14) in MCL.
Originalsprog | Engelsk |
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Tidsskrift | Leukemia Research |
Vol/bind | 38 |
Nummer | 8 |
Sider (fra-til) | 918-24 |
Antal sider | 7 |
ISSN | 0145-2126 |
DOI | |
Status | Udgivet - aug. 2014 |
Fingeraftryk
Dyk ned i forskningsemnerne om 'SOX11 as a minimal residual disease marker for Mantle cell lymphoma'. Sammen danner de et unikt fingeraftryk.Aktiviteter
- 1 Deltagelse i eller organisering af konference
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18th Congress of European Haematology Association
Simonsen, A. T. (Deltager)
13 jun. 2013 → 16 jun. 2013Aktivitet: Deltagelse i eller arrangement af en begivenhed - typer › Deltagelse i eller organisering af konference