SOX11 as a minimal residual disease marker for Mantle cell lymphoma

Anita Tranberg Simonsen, Camilla Darum Sørensen, Lene Hyldahl Ebbesen, Julie Støve Bødker, Hans Herluf Nørregaard Bentzen, Charlotte Guldborg Nyvold

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

11 Citationer (Scopus)

Abstract

Recent studies have identified SOX11 as a novel diagnostic marker for mantle cell lymphoma (MCL). We quantified SOX11 by a truly mRNA specific qPCR assay in longitudinal peripheral blood samples from 20 patients and evidenced a close relationship of SOX11 expression and clinical status of the patients. In eight patient courses we validated the expression of SOX11 using t(11;14) and demonstrated positive correlation of SOX11 and t(11;14) levels. To the best of our knowledge this is the first report stating that quantification of SOX11 can be used as an minimal residual disease marker equal to the key translocation t(11;14) in MCL.

OriginalsprogEngelsk
TidsskriftLeukemia Research
Vol/bind38
Nummer8
Sider (fra-til)918-24
Antal sider7
ISSN0145-2126
DOI
StatusUdgivet - aug. 2014

Fingeraftryk

Dyk ned i forskningsemnerne om 'SOX11 as a minimal residual disease marker for Mantle cell lymphoma'. Sammen danner de et unikt fingeraftryk.

Citationsformater