Soft drink and juice consumption and renal cell carcinoma incidence and mortality in the European Prospective Investigation into Cancer and Nutrition

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  • Alicia K Heath, Imperial College, London, Storbritannien
  • Joanna L Clasen, Imperial College, London, Storbritannien
  • Nick P Jayanth, Imperial College, London, Storbritannien
  • Mazda Jenab, WHO International Agency for Research on Cancer, Frankrig
  • Anne Tjonneland, Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark., Københavns Universitet, Danmark
  • Kristina E N Petersen, Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark., Danmark
  • Kim Overvad
  • Bernard Srour, German Cancer Research Center, Tyskland
  • Verena Katzke, German Cancer Research Center, Tyskland
  • Manuela M Bergmann, German Institute of Human Nutrition Potsdam-Rehbruecke, Tyskland
  • Matthias B Schulze, German Institute of Human Nutrition Potsdam-Rehbruecke, Potsdam, Germany., Institute of Nutritional Sciences, University of Potsdam, Nuthetal, Germany., Tyskland
  • Giovanna Masala, Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO., Italien
  • Vittorio Krogh, Epidemiology and Prevention Unit, Milan, Italy., Italien
  • Rosario Tumino, Cancer Registry and Histopathology Unit, Azienda Sanitaria Provinciale 7, Ragusa, Italy., Italien
  • Alberto Catalano, Department of Clinical and Biological Sciences, University of Turin, Orbassano, Turin, Italien
  • Fabrizio Pasanisi, Dipartimento di Medicina Clinica e Chrurgia, Federico II University, Naples, Italien
  • Magritt Brustad, Department of Community Medicine, UiT The Arctic University of Norway, Tromso, Norway., Norge
  • Karina Standahl Olsen, Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norge
  • Guri Skeie, Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norge
  • Leila Lujan-Barroso, Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain., L'Hospitalet de Llobregat, Barcelona, Spanien
  • Miguel Rodríguez-Barranco, Biosanitary Investigation Institute (IBS) of Granada, University Hospital and University of Granada, Granada, Spain., Escuela Andaluza de Salud Pública (EASP), Granada, Consorcio Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Spanien
  • Pilar Amiano, Public Health Division of Gipuzkoa, Consorcio Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Spanien
  • Carmen Santiuste, Consorcio Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain., Spanien
  • Aurelio Barricarte Gurrea, Navarra Public Health Institute, Navarre Public Health Institute, Pamplona, Navarra Institute for Health Research (IdiSNA), Pamplona, Spain., Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain., Spanien
  • Håkan Axelson, Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Sverige
  • Stina Ramne, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Sverige
  • Borje Ljungberg, Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden., Sverige
  • Eleanor L Watts, Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, United Kingdom., Storbritannien
  • Inge Huybrechts, WHO International Agency for Research on Cancer, Frankrig
  • Elisabete Weiderpass, WHO International Agency for Research on Cancer, Frankrig
  • Elio Riboli, Imperial College, London, Storbritannien
  • David C Muller, Imperial College, London, Storbritannien

BACKGROUND: Renal cell carcinoma (RCC) accounts for more than 80% of kidney cancers in adults and obesity is a known risk factor. Regular consumption of sweetened beverages has been linked to obesity and several chronic diseases including some types of cancer. It is uncertain whether soft drink and juice consumption is associated with risk of RCC. We investigated the associations of soft drink and juice consumption with RCC incidence and mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC).

METHODS: 389,220 EPIC participants with median age 52 years at recruitment (1991-2000) were included. Cox regression yielded adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for RCC incidence and mortality in relation to intakes of juices and total, sugar-sweetened, and artificially-sweetened soft drinks.

RESULTS: 888 incident RCCs and 356 RCC deaths were identified. In models including adjustment for body mass index and energy intake, there was no higher risk of incident RCC associated with consumption of juices (HR per 100 g/day increment=1.03, 95% CI 0.97-1.09), total soft drinks (HR=1.01, 0.98-1.05), sugar-sweetened soft drinks (HR=0.99, 0.94-1.05), or artificially-sweetened soft drinks (HR=1.02, 0.96-1.08). In these fully-adjusted models, none of the beverages were associated with RCC mortality (HR, 95% CI per 100 g/day increment 1.06, 0.97-1.16; 1.03, 0.98-1.09; 0.97, 0.89-1.07; and 1.06, 0.99-1.14, respectively).

CONCLUSIONS: Consumption of juices or soft drinks was not associated with RCC incidence or mortality after adjusting for obesity.

IMPACT: Soft drink and juice intakes are unlikely to play an independent role in RCC development or mortality.

OriginalsprogEngelsk
TidsskriftCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Vol/bind30
Nummer6
Sider (fra-til)1270-1274
Antal sider5
ISSN1055-9965
DOI
StatusUdgivet - jun. 2021

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