Aarhus Universitets segl

English

Du er her: AU » Om AU » Organisation » Small Organic Catalase Mimic Encapsulated in Micellar Art...

Om AU

Small Organic Catalase Mimic Encapsulated in Micellar Artificial Organelles as Reactive Oxygen Species Scavengers

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Standard

Small Organic Catalase Mimic Encapsulated in Micellar Artificial Organelles as Reactive Oxygen Species Scavengers. / Ade, Carina Aileen; Brodszkij, Edit; Thingholm, Bo et al.
I: ACS Applied Polymer Materials, Bind 1, Nr. 6, 06.2019, s. 1532-1539.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Harvard

Ade, CA, Brodszkij, E, Thingholm, B, Gal, N, Itel, FR, Taipaleenmäki, EM, Schattling, P & Stadler, BM 2019, 'Small Organic Catalase Mimic Encapsulated in Micellar Artificial Organelles as Reactive Oxygen Species Scavengers', ACS Applied Polymer Materials, bind 1, nr. 6, s. 1532-1539. https://doi.org/10.1021/acsapm.9b00308

APA

Ade, C. A., Brodszkij, E., Thingholm, B., Gal, N., Itel, F. R., Taipaleenmäki, E. M., Schattling, P., & Stadler, B. M. (2019). Small Organic Catalase Mimic Encapsulated in Micellar Artificial Organelles as Reactive Oxygen Species Scavengers. ACS Applied Polymer Materials, 1(6), 1532-1539. https://doi.org/10.1021/acsapm.9b00308

CBE

Ade CA, Brodszkij E, Thingholm B, Gal N, Itel FR, Taipaleenmäki EM, Schattling P, Stadler BM. 2019. Small Organic Catalase Mimic Encapsulated in Micellar Artificial Organelles as Reactive Oxygen Species Scavengers. ACS Applied Polymer Materials. 1(6):1532-1539. https://doi.org/10.1021/acsapm.9b00308

MLA

Ade, Carina Aileen et al. "Small Organic Catalase Mimic Encapsulated in Micellar Artificial Organelles as Reactive Oxygen Species Scavengers". ACS Applied Polymer Materials. 2019, 1(6). 1532-1539. https://doi.org/10.1021/acsapm.9b00308

Vancouver

Ade CA, Brodszkij E, Thingholm B, Gal N, Itel FR, Taipaleenmäki EM et al. Small Organic Catalase Mimic Encapsulated in Micellar Artificial Organelles as Reactive Oxygen Species Scavengers. ACS Applied Polymer Materials. 2019 jun.;1(6):1532-1539. doi: 10.1021/acsapm.9b00308

Author

Ade, Carina Aileen ; Brodszkij, Edit ; Thingholm, Bo et al. / Small Organic Catalase Mimic Encapsulated in Micellar Artificial Organelles as Reactive Oxygen Species Scavengers. I: ACS Applied Polymer Materials. 2019 ; Bind 1, Nr. 6. s. 1532-1539.

Bibtex

@article{db850e64ff5c4a7ca218a2ba9fceb29b,
title = "Small Organic Catalase Mimic Encapsulated in Micellar Artificial Organelles as Reactive Oxygen Species Scavengers",
abstract = "Biocatalytic intracellular active nanoreactors (artificial organelles) aim to support their host cells. Here, we report the first successful micelle-based artificial organelles containing a salen–manganese complex (EUK) as catalase mimic with intracellular activity in HepG2 cells to act as reactive oxygen species (ROS) scavengers. Four different EUKs were synthesized and compared in their ability to convert hydrogen peroxide to water and oxygen as free compounds and when encapsulated into micelles assembled from the amphiphilic block copolymer poly(cholesteryl methacrylate)-block-poly(2-(dimethylamino)ethyl methacrylate). An EUK candidate with an asymmetric substitution of chemical groups at the ortho and the meta position (EUK-B) was identified as lead candidate. HepG2 cells continued proliferating when preincubated with low concentrations of EUK-B-containing micelles (MB). Importantly, HepG2 cells equipped with MB showed improved viability compared to the controls when stressed with paraquat, a compound that induces ROS generation. The intracellular activity of MB was supported by lower amounts of intracellular detectable ROS. This first report on the combination of artificial enzymes and artificial organelles further extends the opportunities in therapeutic cell mimicry.",
author = "Ade, {Carina Aileen} and Edit Brodszkij and Bo Thingholm and Noga Gal and Itel, {Fabian Robert} and Taipaleenm{\"a}ki, {Essi Marika} and Philipp Schattling and Stadler, {Brigitte Maria}",
year = "2019",
month = jun,
doi = "10.1021/acsapm.9b00308",
language = "English",
volume = "1",
pages = "1532--1539",
journal = "ACS Applied Polymer Materials",
issn = "2637-6105",
publisher = "ACS Publications",
number = "6",

}

RIS

TY - JOUR

T1 - Small Organic Catalase Mimic Encapsulated in Micellar Artificial Organelles as Reactive Oxygen Species Scavengers

AU - Ade, Carina Aileen

AU - Brodszkij, Edit

AU - Thingholm, Bo

AU - Gal, Noga

AU - Itel, Fabian Robert

AU - Taipaleenmäki, Essi Marika

AU - Schattling, Philipp

AU - Stadler, Brigitte Maria

PY - 2019/6

Y1 - 2019/6

N2 - Biocatalytic intracellular active nanoreactors (artificial organelles) aim to support their host cells. Here, we report the first successful micelle-based artificial organelles containing a salen–manganese complex (EUK) as catalase mimic with intracellular activity in HepG2 cells to act as reactive oxygen species (ROS) scavengers. Four different EUKs were synthesized and compared in their ability to convert hydrogen peroxide to water and oxygen as free compounds and when encapsulated into micelles assembled from the amphiphilic block copolymer poly(cholesteryl methacrylate)-block-poly(2-(dimethylamino)ethyl methacrylate). An EUK candidate with an asymmetric substitution of chemical groups at the ortho and the meta position (EUK-B) was identified as lead candidate. HepG2 cells continued proliferating when preincubated with low concentrations of EUK-B-containing micelles (MB). Importantly, HepG2 cells equipped with MB showed improved viability compared to the controls when stressed with paraquat, a compound that induces ROS generation. The intracellular activity of MB was supported by lower amounts of intracellular detectable ROS. This first report on the combination of artificial enzymes and artificial organelles further extends the opportunities in therapeutic cell mimicry.

AB - Biocatalytic intracellular active nanoreactors (artificial organelles) aim to support their host cells. Here, we report the first successful micelle-based artificial organelles containing a salen–manganese complex (EUK) as catalase mimic with intracellular activity in HepG2 cells to act as reactive oxygen species (ROS) scavengers. Four different EUKs were synthesized and compared in their ability to convert hydrogen peroxide to water and oxygen as free compounds and when encapsulated into micelles assembled from the amphiphilic block copolymer poly(cholesteryl methacrylate)-block-poly(2-(dimethylamino)ethyl methacrylate). An EUK candidate with an asymmetric substitution of chemical groups at the ortho and the meta position (EUK-B) was identified as lead candidate. HepG2 cells continued proliferating when preincubated with low concentrations of EUK-B-containing micelles (MB). Importantly, HepG2 cells equipped with MB showed improved viability compared to the controls when stressed with paraquat, a compound that induces ROS generation. The intracellular activity of MB was supported by lower amounts of intracellular detectable ROS. This first report on the combination of artificial enzymes and artificial organelles further extends the opportunities in therapeutic cell mimicry.

U2 - 10.1021/acsapm.9b00308

DO - 10.1021/acsapm.9b00308

M3 - Journal article

VL - 1

SP - 1532

EP - 1539

JO - ACS Applied Polymer Materials

JF - ACS Applied Polymer Materials

SN - 2637-6105

IS - 6

ER -