Sleep and allostatic load: A systematic review and meta-analysis

Dinne Skjærlund Christensen, Robert Zachariae, Ali Amidi , Lisa Maria Wu*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

35 Downloads (Pure)


The detrimental effects of sleep disturbances on health and wellbeing are well-established but not fully understood. The allostatic load model has been suggested as a framework for understanding the adverse effects of sleep disturbances. We conducted a systematic review and meta-analysis to examine the associations of sleep disturbance and sleep duration with allostatic load. PubMed, PsycINFO, Embase, and Web of Science were searched for records relating to sleep and allostatic load published from 1993 to January 14th, 2022. Two independent raters screened 395 titles and abstracts and 51 full texts. Data were extracted from 18 studies that were assessed for methodological quality. Of these, 17 studies of 26,924 participants were included in the meta-analysis. Sleep disturbance was significantly associated with higher allostatic load (effect size correlation [ESr] = 0.09, p < 0.001), and the association was weaker in samples with a larger proportion of women. When compared to normal sleep, long sleep was significantly associated with higher allostatic load (ESr = 0.12, p = 0.003). Results indicated heterogeneity. No association was found for short sleep (ESr = 0.05, p = 0.069) or sleep duration (ESr = −0.06, p = 0.36). Future research should identify mechanisms and directionality in longitudinal studies.

TidsskriftSleep Medicine Reviews
StatusUdgivet - aug. 2022


Dyk ned i forskningsemnerne om 'Sleep and allostatic load: A systematic review and meta-analysis'. Sammen danner de et unikt fingeraftryk.