Sit-to-stand power predicts functional performance and patient-reported outcomes in patients with advanced knee osteoarthritis. A cross-sectional study

TY - JOUR

T1 - Sit-to-stand power predicts functional performance and patient-reported outcomes in patients with advanced knee osteoarthritis. A cross-sectional study

AU - Langgård Jørgensen, Stian

AU - Mechlenburg, Inger

AU - Bagger Bohn, Marie

AU - Aagaard, Per

N1 - Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2024/2

Y1 - 2024/2

N2 - BACKGROUND: Lower limb muscle power is positively associated with functional performance and patient-reported outcomes (PROMs) and suggested as an important variable to evaluate in patients with advanced knee osteoarthritis (OA).OBJECTIVES: To explore the association between muscle power derived from the 30-sec sit-to-stand test (STS power) with functional performance and PROMs compared to maximal isometric knee extensor strength (KE MVC) in male- and female patients with advanced OA.STUDY DESIGN: Cross-sectional design.METHODS: Eighty-six patients (66.6 [64.9-67.7]years) with advanced knee OA were included. Dependent variables were STS power and KE MVC. Independent variables were Timed Up&Go (TUG), 40-m fast-paced walk test (40mFWT), Knee injury and Osteoarthritis Outcome Score (KOOS) subscales.COVARIATE: Age.ANALYSES: Simple linear- and multiple regression analyses with and without adjusting for age. Pitman's test was used to evaluate differences in correlation strength among dependent variables.RESULTS: STS power demonstrated a statistical relationship with TUG and 40mFWT for both sexes (β coefficients -1.11 to -4.36 (p < 0.05), r2 = 0.47-0.55 (p < 0.05)), and with KOOS Pain, ADL, and Sport for male patients (β coefficients 6.53 to 7.17 (p < 0.05), r2 = 0.29-0.33 (p < 0.05)). Knee extensor MVC demonstrated no relationship with any outcomes for male patients or female patients. STS power displayed statistically stronger correlation to functional performance.CONCLUSION: STS power was associated with functional performance in both male patients and female patients suffering from advanced knee OA. Moreover, STS power was associated with KOOS Pain, Sport, and ADLin male patients. The assessment of STS power should be considered in the evaluation of patients with advanced knee OA.TRIAL REGISTRATION NUMBER: NCT04081493.

AB - BACKGROUND: Lower limb muscle power is positively associated with functional performance and patient-reported outcomes (PROMs) and suggested as an important variable to evaluate in patients with advanced knee osteoarthritis (OA).OBJECTIVES: To explore the association between muscle power derived from the 30-sec sit-to-stand test (STS power) with functional performance and PROMs compared to maximal isometric knee extensor strength (KE MVC) in male- and female patients with advanced OA.STUDY DESIGN: Cross-sectional design.METHODS: Eighty-six patients (66.6 [64.9-67.7]years) with advanced knee OA were included. Dependent variables were STS power and KE MVC. Independent variables were Timed Up&Go (TUG), 40-m fast-paced walk test (40mFWT), Knee injury and Osteoarthritis Outcome Score (KOOS) subscales.COVARIATE: Age.ANALYSES: Simple linear- and multiple regression analyses with and without adjusting for age. Pitman's test was used to evaluate differences in correlation strength among dependent variables.RESULTS: STS power demonstrated a statistical relationship with TUG and 40mFWT for both sexes (β coefficients -1.11 to -4.36 (p < 0.05), r2 = 0.47-0.55 (p < 0.05)), and with KOOS Pain, ADL, and Sport for male patients (β coefficients 6.53 to 7.17 (p < 0.05), r2 = 0.29-0.33 (p < 0.05)). Knee extensor MVC demonstrated no relationship with any outcomes for male patients or female patients. STS power displayed statistically stronger correlation to functional performance.CONCLUSION: STS power was associated with functional performance in both male patients and female patients suffering from advanced knee OA. Moreover, STS power was associated with KOOS Pain, Sport, and ADLin male patients. The assessment of STS power should be considered in the evaluation of patients with advanced knee OA.TRIAL REGISTRATION NUMBER: NCT04081493.

KW - Functional performance

KW - Knee

KW - Knee osteoarthritis

KW - Muscle power

KW - Patient-reported outcome

U2 - 10.1016/j.msksp.2023.102899

DO - 10.1016/j.msksp.2023.102899

M3 - Journal article

C2 - 38141496

SN - 2468-7812

VL - 69

JO - Musculoskeletal Science and Practice

JF - Musculoskeletal Science and Practice

M1 - 102899

ER -