Singlet oxygen quenching by riboflavin

Malgorzata Insinska-Rak, Petr Henke, Thomas Breitenbach, Peter Remsen Ogilby*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

1 Citationer (Scopus)

Abstract

Derivatives of riboflavin, specifically flavin mononucleotide, have recently been in the spotlight as the active component in protein-encased optogenetic sensitizers to produce singlet oxygen, O 2(a 1Δ g). The extent to which riboflavin deactivates singlet oxygen is a key aspect of these studies. Surprisingly, there is a dearth of information on the rate constant for riboflavin-mediated singlet oxygen removal. We now report that, when riboflavin is dissolved in both aqueous and methanol solutions, the rate constant for riboflavin-mediated removal of singlet oxygen cannot be greater than ∼ 2 × 10 5 s −1 M −1. This number is appreciably smaller than what has been reported in the literature and, as such, our results can be significant for mechanistic interpretations of photo-processes that involve flavins in oxygenated systems.

OriginalsprogEngelsk
Artikelnummer115108
TidsskriftJournal of Photochemistry and Photobiology A: Chemistry
Vol/bind446
Antal sider6
ISSN1010-6030
DOI
StatusUdgivet - jan. 2024

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