Single cell polarity in liquid phase facilitates tumour metastasis

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Single cell polarity in liquid phase facilitates tumour metastasis. / Lorentzen, Anna; Becker, Paul F.; Kosla, Jan; Saini, Massimo; Weidele, Kathrin; Ronchi, Paolo; Klein, Corinna; Wolf, Monika J.; Geist, Felix; Seubert, Bastian; Ringelhan, Marc; Mihic-Probst, Daniela; Esser, Knud; Roblek, Marko; Kuehne, Felix; Bianco, Gaia; O'Connor, Tracy; Müller, Quentin; Schuck, Kathleen; Lange, Sebastian; Hartmann, Daniel; Spaich, Saskia; Groß, Olaf; Utikal, Jochen; Haferkamp, Sebastian; Sprick, Martin R.; Damle-Vartak, Amruta; Hapfelmeier, Alexander; Hüser, Norbert; Protzer, Ulrike; Trumpp, Andreas; Saur, Dieter; Vartak, Nachiket; Klein, Christoph A.; Polzer, Bernhard; Borsig, Lubor; Heikenwalder, Mathias.

I: Nature Communications, Bind 9, Nr. 1, 887, 01.12.2018.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Lorentzen, A, Becker, PF, Kosla, J, Saini, M, Weidele, K, Ronchi, P, Klein, C, Wolf, MJ, Geist, F, Seubert, B, Ringelhan, M, Mihic-Probst, D, Esser, K, Roblek, M, Kuehne, F, Bianco, G, O'Connor, T, Müller, Q, Schuck, K, Lange, S, Hartmann, D, Spaich, S, Groß, O, Utikal, J, Haferkamp, S, Sprick, MR, Damle-Vartak, A, Hapfelmeier, A, Hüser, N, Protzer, U, Trumpp, A, Saur, D, Vartak, N, Klein, CA, Polzer, B, Borsig, L & Heikenwalder, M 2018, 'Single cell polarity in liquid phase facilitates tumour metastasis', Nature Communications, bind 9, nr. 1, 887. https://doi.org/10.1038/s41467-018-03139-6

APA

Lorentzen, A., Becker, P. F., Kosla, J., Saini, M., Weidele, K., Ronchi, P., Klein, C., Wolf, M. J., Geist, F., Seubert, B., Ringelhan, M., Mihic-Probst, D., Esser, K., Roblek, M., Kuehne, F., Bianco, G., O'Connor, T., Müller, Q., Schuck, K., ... Heikenwalder, M. (2018). Single cell polarity in liquid phase facilitates tumour metastasis. Nature Communications, 9(1), [887]. https://doi.org/10.1038/s41467-018-03139-6

CBE

Lorentzen A, Becker PF, Kosla J, Saini M, Weidele K, Ronchi P, Klein C, Wolf MJ, Geist F, Seubert B, Ringelhan M, Mihic-Probst D, Esser K, Roblek M, Kuehne F, Bianco G, O'Connor T, Müller Q, Schuck K, Lange S, Hartmann D, Spaich S, Groß O, Utikal J, Haferkamp S, Sprick MR, Damle-Vartak A, Hapfelmeier A, Hüser N, Protzer U, Trumpp A, Saur D, Vartak N, Klein CA, Polzer B, Borsig L, Heikenwalder M. 2018. Single cell polarity in liquid phase facilitates tumour metastasis. Nature Communications. 9(1):Article 887. https://doi.org/10.1038/s41467-018-03139-6

MLA

Vancouver

Lorentzen A, Becker PF, Kosla J, Saini M, Weidele K, Ronchi P o.a. Single cell polarity in liquid phase facilitates tumour metastasis. Nature Communications. 2018 dec 1;9(1). 887. https://doi.org/10.1038/s41467-018-03139-6

Author

Lorentzen, Anna ; Becker, Paul F. ; Kosla, Jan ; Saini, Massimo ; Weidele, Kathrin ; Ronchi, Paolo ; Klein, Corinna ; Wolf, Monika J. ; Geist, Felix ; Seubert, Bastian ; Ringelhan, Marc ; Mihic-Probst, Daniela ; Esser, Knud ; Roblek, Marko ; Kuehne, Felix ; Bianco, Gaia ; O'Connor, Tracy ; Müller, Quentin ; Schuck, Kathleen ; Lange, Sebastian ; Hartmann, Daniel ; Spaich, Saskia ; Groß, Olaf ; Utikal, Jochen ; Haferkamp, Sebastian ; Sprick, Martin R. ; Damle-Vartak, Amruta ; Hapfelmeier, Alexander ; Hüser, Norbert ; Protzer, Ulrike ; Trumpp, Andreas ; Saur, Dieter ; Vartak, Nachiket ; Klein, Christoph A. ; Polzer, Bernhard ; Borsig, Lubor ; Heikenwalder, Mathias. / Single cell polarity in liquid phase facilitates tumour metastasis. I: Nature Communications. 2018 ; Bind 9, Nr. 1.

Bibtex

@article{1254471b318a4c7dbeb2215c03feed94,
title = "Single cell polarity in liquid phase facilitates tumour metastasis",
abstract = "Dynamic polarisation of tumour cells is essential for metastasis. While the role of polarisation during dedifferentiation and migration is well established, polarisation of metastasising tumour cells during phases of detachment has not been investigated. Here we identify and characterise a type of polarisation maintained by single cells in liquid phase termed single-cell (sc) polarity and investigate its role during metastasis. We demonstrate that sc polarity is an inherent feature of cells from different tumour entities that is observed in circulating tumour cells in patients. Functionally, we propose that the sc pole is directly involved in early attachment, thereby affecting adhesion, transmigration and metastasis. In vivo, the metastatic capacity of cell lines correlates with the extent of sc polarisation. By manipulating sc polarity regulators and by generic depolarisation, we show that sc polarity prior to migration affects transmigration and metastasis in vitro and in vivo.",
author = "Anna Lorentzen and Becker, {Paul F.} and Jan Kosla and Massimo Saini and Kathrin Weidele and Paolo Ronchi and Corinna Klein and Wolf, {Monika J.} and Felix Geist and Bastian Seubert and Marc Ringelhan and Daniela Mihic-Probst and Knud Esser and Marko Roblek and Felix Kuehne and Gaia Bianco and Tracy O'Connor and Quentin M{\"u}ller and Kathleen Schuck and Sebastian Lange and Daniel Hartmann and Saskia Spaich and Olaf Gro{\ss} and Jochen Utikal and Sebastian Haferkamp and Sprick, {Martin R.} and Amruta Damle-Vartak and Alexander Hapfelmeier and Norbert H{\"u}ser and Ulrike Protzer and Andreas Trumpp and Dieter Saur and Nachiket Vartak and Klein, {Christoph A.} and Bernhard Polzer and Lubor Borsig and Mathias Heikenwalder",
year = "2018",
month = dec,
day = "1",
doi = "10.1038/s41467-018-03139-6",
language = "English",
volume = "9",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Single cell polarity in liquid phase facilitates tumour metastasis

AU - Lorentzen, Anna

AU - Becker, Paul F.

AU - Kosla, Jan

AU - Saini, Massimo

AU - Weidele, Kathrin

AU - Ronchi, Paolo

AU - Klein, Corinna

AU - Wolf, Monika J.

AU - Geist, Felix

AU - Seubert, Bastian

AU - Ringelhan, Marc

AU - Mihic-Probst, Daniela

AU - Esser, Knud

AU - Roblek, Marko

AU - Kuehne, Felix

AU - Bianco, Gaia

AU - O'Connor, Tracy

AU - Müller, Quentin

AU - Schuck, Kathleen

AU - Lange, Sebastian

AU - Hartmann, Daniel

AU - Spaich, Saskia

AU - Groß, Olaf

AU - Utikal, Jochen

AU - Haferkamp, Sebastian

AU - Sprick, Martin R.

AU - Damle-Vartak, Amruta

AU - Hapfelmeier, Alexander

AU - Hüser, Norbert

AU - Protzer, Ulrike

AU - Trumpp, Andreas

AU - Saur, Dieter

AU - Vartak, Nachiket

AU - Klein, Christoph A.

AU - Polzer, Bernhard

AU - Borsig, Lubor

AU - Heikenwalder, Mathias

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Dynamic polarisation of tumour cells is essential for metastasis. While the role of polarisation during dedifferentiation and migration is well established, polarisation of metastasising tumour cells during phases of detachment has not been investigated. Here we identify and characterise a type of polarisation maintained by single cells in liquid phase termed single-cell (sc) polarity and investigate its role during metastasis. We demonstrate that sc polarity is an inherent feature of cells from different tumour entities that is observed in circulating tumour cells in patients. Functionally, we propose that the sc pole is directly involved in early attachment, thereby affecting adhesion, transmigration and metastasis. In vivo, the metastatic capacity of cell lines correlates with the extent of sc polarisation. By manipulating sc polarity regulators and by generic depolarisation, we show that sc polarity prior to migration affects transmigration and metastasis in vitro and in vivo.

AB - Dynamic polarisation of tumour cells is essential for metastasis. While the role of polarisation during dedifferentiation and migration is well established, polarisation of metastasising tumour cells during phases of detachment has not been investigated. Here we identify and characterise a type of polarisation maintained by single cells in liquid phase termed single-cell (sc) polarity and investigate its role during metastasis. We demonstrate that sc polarity is an inherent feature of cells from different tumour entities that is observed in circulating tumour cells in patients. Functionally, we propose that the sc pole is directly involved in early attachment, thereby affecting adhesion, transmigration and metastasis. In vivo, the metastatic capacity of cell lines correlates with the extent of sc polarisation. By manipulating sc polarity regulators and by generic depolarisation, we show that sc polarity prior to migration affects transmigration and metastasis in vitro and in vivo.

UR - http://www.scopus.com/inward/record.url?scp=85042774764&partnerID=8YFLogxK

U2 - 10.1038/s41467-018-03139-6

DO - 10.1038/s41467-018-03139-6

M3 - Journal article

C2 - 29491397

AN - SCOPUS:85042774764

VL - 9

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 887

ER -