Significance of Reversal-Resorption Phase in Bone Loss

Thomas Levin Andersen; Jean Marie Delaisse; Jesper Skovhus Thomsen; Christina Møller Andreasen

doi:10.1007/978-981-16-5613-2_7

Significance of Reversal-Resorption Phase in Bone Loss

Thomas Levin Andersen^*
, Jean Marie Delaisse
, Jesper Skovhus Thomsen
, Christina Møller Andreasen

^*Corresponding author af dette arbejde

Publikation: Bidrag til bog/antologi/rapport/proceeding › Bidrag til bog/antologi › Forskning › peer review

7 Citationer (Scopus)

Abstract

The latest revision of the bone remodeling process has now established that it involves three successive phases: (1) a short initial resorption phase by primary osteoclasts, (2) a longer reversal-resorption phase with intermixed osteoblastic reversal cells and secondary osteoclasts, and (3) a subsequent formation phase. The present chapter focuses on: (1) the histological characteristics of remodeling sites within the reversal-resorption phase, (2) a new definition of the eroded surfaces largely reflecting the reversal-resorption phase, (3) the histological characteristics of eroded surfaces arrested within the reversal-resorption phase, (4) the contribution of a prolonged reversal-resorption phase to the bone loss with age, utilizing cortical porosity as a measure of the bone loss.

Originalsprog	Engelsk
Titel	Osteoporotic Fracture and Systemic Skeletal Disorders : Mechanism, Assessment, and Treatment
Antal sider	10
Forlag	Springer Nature
Publikationsdato	1 jan. 2021
Sider	101-110
ISBN (Trykt)	9789811656125
ISBN (Elektronisk)	9789811656132
DOI	https://doi.org/10.1007/978-981-16-5613-2_7
Status	Udgivet - 1 jan. 2021

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Significance of Reversal-Resorption Phase in Bone Loss. / Andersen, Thomas Levin; Delaisse, Jean Marie; Thomsen, Jesper Skovhus et al.
Osteoporotic Fracture and Systemic Skeletal Disorders: Mechanism, Assessment, and Treatment. Springer Nature, 2021. s. 101-110.

Publikation: Bidrag til bog/antologi/rapport/proceeding › Bidrag til bog/antologi › Forskning › peer review

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N2 - The latest revision of the bone remodeling process has now established that it involves three successive phases: (1) a short initial resorption phase by primary osteoclasts, (2) a longer reversal-resorption phase with intermixed osteoblastic reversal cells and secondary osteoclasts, and (3) a subsequent formation phase. The present chapter focuses on: (1) the histological characteristics of remodeling sites within the reversal-resorption phase, (2) a new definition of the eroded surfaces largely reflecting the reversal-resorption phase, (3) the histological characteristics of eroded surfaces arrested within the reversal-resorption phase, (4) the contribution of a prolonged reversal-resorption phase to the bone loss with age, utilizing cortical porosity as a measure of the bone loss.

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KW - Cortical porosity

KW - Cortical thinning

KW - Coupling

KW - Osteoblasts

KW - Osteoclasts

KW - Osteoporosis

KW - Remodeling-based bone formation

KW - Reversal phase

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Significance of Reversal-Resorption Phase in Bone Loss

Abstract

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