Sex specific associations in genome wide association analysis of renal cell carcinoma

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Ruhina S Laskar, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • David C Muller, Faculty of Medicine, School of Public Health, Imperial College London, London, United Kingdom., Storbritannien
  • Peng Li, Max Planck Institute for Demographic Research, Rostock, Germany., Tyskland
  • Mitchell J Machiela, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA., USA
  • Yuanqing Ye, Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., USA
  • Valerie Gaborieau, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Matthieu Foll, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Jonathan N Hofmann, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA., USA
  • Leandro Colli, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA., USA
  • Joshua N Sampson, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA., USA
  • Zhaoming Wang, Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., USA
  • Delphine Bacq-Daian, Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France., Frankrig
  • Anne Boland, Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France., Frankrig
  • Behnoush Abedi-Ardekani, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Geoffroy Durand, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Florence Le Calvez-Kelm, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Nivonirina Robinot, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Helene Blanche, Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain, Paris, France., Frankrig
  • Egor Prokhortchouk, Kurchatov Scientific Center, Moscow, Russian Federation., Rusland
  • Konstantin G Skryabin, Kurchatov Scientific Center, Moscow, Russian Federation., Rusland
  • Laurie Burdett, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA., USA
  • Meredith Yeager, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA., USA
  • Sanja Radojevic-Skodric, Institute of Pathology, Medical school of Belgrade, Belgrade, Serbia., Serbien
  • Slavisa Savic, Department of Urology, University Hospital "Dr D. Misovic" Clinical Center, Belgrade, Serbia., Serbien
  • Lenka Foretova, Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Zluty kopec 7, 65653, Brno, Czech Republic., Tjekkiet
  • Ivana Holcatova, 2nd Faculty of Medicine, Institute of Public Health and Preventive Medicine, Charles University, Prague, Czech Republic., Tjekkiet
  • Vladimir Janout, Faculty of Health Sciences, Palacky University, Olomouc, Czech Republic., Tjekkiet
  • Dana Mates, National Institute of Public Health, Bucharest, Romania., Rumænien
  • Stefan Rascu, Carol Davila University of Medicine and Pharmacy, Th. Burghele Hospital, Bucharest, Romania., Rumænien
  • Anush Mukeria, Russian N.N. Blokhin Cancer Research Centre, Rusland
  • David Zaridze, Russian N.N. Blokhin Cancer Research Centre, Rusland
  • Vladimir Bencko, First Faculty of Medicine, Institute of Hygiene and Epidemiology, Charles University, Prague, Czech Republic., Tjekkiet
  • Cezary Cybulski, International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland, Polen
  • Eleonora Fabianova, Regional Authority of Public Health in BanskaBystrica, BanskaBystrica, Slovakia., Slovakiet
  • Viorel Jinga, Carol Davila University of Medicine and Pharmacy, Th. Burghele Hospital, Bucharest, Romania., Rumænien
  • Jolanta Lissowska, The M Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland., Polen
  • Jan Lubinski, International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland, Polen
  • Marie Navratilova, Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Zluty kopec 7, 65653, Brno, Czech Republic., Tjekkiet
  • Peter Rudnai, National Public Health Institute, Budapest, Hungary., Ungarn
  • Beata Świątkowska, Department of Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland., Polen
  • Simone Benhamou, CNRS UMR8200, Institute Gustave Roussy, Villejuif, France., INSERM U946, Frankrig
  • Geraldine Cancel-Tassin, CeRePP, Tenon Hospital, 75020, Paris, France., Frankrig
  • Olivier Cussenot, CeRePP, Tenon Hospital, 75020, Paris, France., Frankrig
  • Antonia Trichopoulou, Hellenic Health Foundation, Alexandroupoleos 23, Athens, 11527, Greece., Grækenland
  • Elio Riboli, Faculty of Medicine, School of Public Health, Imperial College London, London, United Kingdom., Storbritannien
  • Kim Overvad
  • Salvatore Panico, Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Federico II University, Naples, Italy., Italien
  • Borje Ljungberg, Umeå University, Sverige
  • Raviprakash T Sitaram, Umeå University, Sverige
  • Graham G Giles, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville Victoria, 3010, Australia., Cancer Epidemiology & Intelligence Division, Cancer Council of Victoria, 615 St Kilda Road, Melbourne, VIC, 3004, Australia., Australien
  • Roger L Milne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville Victoria, 3010, Australia., Cancer Epidemiology & Intelligence Division, Cancer Council of Victoria, 615 St Kilda Road, Melbourne, VIC, 3004, Australia., Australien
  • Gianluca Severi, Inserm U1018, Center for Research in Epidemiology and Population Health (CESP), Facultés de Medicine, Université Paris-Saclay, Université Paris-Sud, UVSQ, Gustave Roussy, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France., Cancer Epidemiology & Intelligence Division, Cancer Council of Victoria, 615 St Kilda Road, Melbourne, VIC, 3004, Australia., Frankrig
  • Fiona Bruinsma, Cancer Epidemiology & Intelligence Division, Cancer Council of Victoria, 615 St Kilda Road, Melbourne, VIC, 3004, Australia., Australien
  • Tony Fletcher, London School of Hygiene and Tropical Medicine, University of London, UK, Storbritannien
  • Kvetoslava Koppova, Regional Authority of Public Health in BanskaBystrica, BanskaBystrica, Slovakia., Slovakiet
  • Susanna C Larsson, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Sverige
  • Alicja Wolk, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Sverige
  • Rosamonde E Banks, Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital, Leeds, UK., Storbritannien
  • Peter J Selby, Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital, Leeds, UK., Storbritannien
  • Douglas F Easton, University of Cambridge, Storbritannien
  • Paul Pharoah, University of Cambridge, Storbritannien
  • Gabriella Andreotti, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA., USA
  • Laura E Beane Freeman, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA., USA
  • Stella Koutros, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA., USA
  • Demetrius Albanes, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA., USA
  • Satu Männistö, National Institute for Health and Welfare (THL), Helsinki, Finland., Finland
  • Stephanie Weinstein, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA., USA
  • Peter E Clark, Vanderbilt-Ingram Cancer Center, Nasville, TN, USA., USA
  • Todd L Edwards, Vanderbilt-Ingram Cancer Center, Nasville, TN, USA., USA
  • Loren Lipworth, Vanderbilt-Ingram Cancer Center, Nasville, TN, USA., USA
  • Hallie Carol, Dana-Farber Cancer Institute, Bostan, MA, USA., USA
  • Matthew L Freedman, Dana-Farber Cancer Institute, Bostan, MA, USA., USA
  • Mark M Pomerantz, Dana-Farber Cancer Institute, Bostan, MA, USA., USA
  • Eunyoung Cho, Brown University, USA
  • Peter Kraft, Harvard T.H. Chan School of Public Health, Boston, MA, USA
  • Mark A Preston, Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School Boston, Boston, Massachusetts., USA
  • Kathryn M Wilson, Harvard T.H. Chan School of Public Health, Boston, MA, USA
  • J Michael Gaziano, Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School Boston, Boston, Massachusetts., USA
  • Howard D Sesso, Harvard T.H. Chan School of Public Health, Boston, MA, USA
  • Amanda Black, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA., USA
  • Neal D Freedman, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA., USA
  • Wen-Yi Huang, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA., USA
  • John G Anema, Division of Urology, Spectrum Health, Grand Rapids, MI, USA., USA
  • Richard J Kahnoski, Division of Urology, Spectrum Health, Grand Rapids, MI, USA., USA
  • Brian R Lane, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA., Division of Urology, Spectrum Health, Grand Rapids, MI, USA., USA
  • Sabrina L Noyes, Van Andel Research Institute, Center for Cancer Genomics and Quantitative Biology, Grand Rapids, MI, USA., USA
  • David Petillo, Van Andel Research Institute, Center for Cancer Genomics and Quantitative Biology, Grand Rapids, MI, USA., USA
  • Bin Tean Teh, Van Andel Research Institute, Center for Cancer Genomics and Quantitative Biology, Grand Rapids, MI, USA., USA
  • Ulrike Peters, Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., USA
  • Emily White, Cancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., USA
  • Garnet L Anderson, Fred Hutchinson Cancer Research Center, Seattle, 98109-1024, WA, USA., USA
  • Lisa Johnson, Fred Hutchinson Cancer Research Center, Seattle, 98109-1024, WA, USA., USA
  • Juhua Luo, Department of Epidemiology and Biostatistics, School of Public Health Indiana University Bloomington, Bloomington, IN, USA., USA
  • Wong-Ho Chow, Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., USA
  • Lee E Moore, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA., USA
  • Toni K Choueiri, Dana-Farber Cancer Institute, Bostan, MA, USA., USA
  • Christopher Wood, Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., USA
  • Mattias Johansson, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • James D McKay, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Kevin M Brown, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA., USA
  • Nathaniel Rothman, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA., USA
  • Mark G Lathrop, McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada., Canada
  • Jean-Francois Deleuze, Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain, Paris, France., Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France., Frankrig
  • Xifeng Wu, Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., USA
  • Paul Brennan, International Agency for Research on Cancer (IARC-WHO), Lyon, France., Frankrig
  • Stephen J Chanock, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA., USA
  • Mark P Purdue, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, 9609 Medical Center Dr, Bethesda, MD, 20892, USA., USA
  • Ghislaine Scelo, International Agency for Research on Cancer (IARC), Lyon, France. scelog@iarc.fr., Frankrig

Renal cell carcinoma (RCC) has an undisputed genetic component and a stable 2:1 male to female sex ratio in its incidence across populations, suggesting possible sexual dimorphism in its genetic susceptibility. We conducted the first sex-specific genome-wide association analysis of RCC for men (3227 cases, 4916 controls) and women (1992 cases, 3095 controls) of European ancestry from two RCC genome-wide scans and replicated the top findings using an additional series of men (2261 cases, 5852 controls) and women (1399 cases, 1575 controls) from two independent cohorts of European origin. Our study confirmed sex-specific associations for two known RCC risk loci at 14q24.2 (DPF3) and 2p21(EPAS1). We also identified two additional suggestive male-specific loci at 6q24.3 (SAMD5, male odds ratio (ORmale) = 0.83 [95% CI = 0.78-0.89], Pmale = 1.71 × 10-8 compared with female odds ratio (ORfemale) = 0.98 [95% CI = 0.90-1.07], Pfemale = 0.68) and 12q23.3 (intergenic, ORmale = 0.75 [95% CI = 0.68-0.83], Pmale = 1.59 × 10-8 compared with ORfemale = 0.93 [95% CI = 0.82-1.06], Pfemale = 0.21) that attained genome-wide significance in the joint meta-analysis. Herein, we provide evidence of sex-specific associations in RCC genetic susceptibility and advocate the necessity of larger genetic and genomic studies to unravel the endogenous causes of sex bias in sexually dimorphic traits and diseases like RCC.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Human Genetics
Vol/bind27
Nummer10
Sider (fra-til)1589-1598
Antal sider10
ISSN1018-4813
DOI
StatusUdgivet - okt. 2019

Se relationer på Aarhus Universitet Citationsformater

ID: 157339508