Severe steroid refractory gastritis induced by Nivolumab: A case report

Helene Hjorth Vindum; Jørgen S. Agnholt; Anders Winther Moelby Nielsen; Mette Bak Nielsen; Henrik Schmidt

doi:10.3748/wjg.v26.i16.1971

Severe steroid refractory gastritis induced by Nivolumab: A case report

Helene Hjorth Vindum, Jørgen S. Agnholt, Anders Winther Moelby Nielsen, Mette Bak Nielsen, Henrik Schmidt

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

20 Citationer (Scopus)

36 Downloads (Pure)

Abstract

BACKGROUND: Immune checkpoint inhibitors are widely used for treatment of many advanced malignancies. Lower gastrointestinal (GI) side effects, such as diarrhea and colitis, are common, but upper GI side effects are rarely reported. Consequently, the correct treatment of upper GI adverse events has been less frequently described.

CASE SUMMARY: We describe a case of a 16-year-old woman with stage IIIb malignant melanoma treated with adjuvant monotherapy using Nivolumab. The patient developed severe gastritis after six series of Nivolumab with weight loss, nausea, and vomiting. There was no effect of intravenous steroids, but the patient´s condition resolved after administration of Infliximab.

CONCLUSION: This case report supports the same treatment for gastritis as for colitis, which is in line with current guidelines.

Originalsprog	Engelsk
Tidsskrift	World Journal of Gastroenterology
Vol/bind	26
Nummer	16
Sider (fra-til)	1971-1978
Antal sider	8
ISSN	1007-9327
DOI	https://doi.org/10.3748/wjg.v26.i16.1971 https://doi.org/10.3748/wjg.v26.i16.1971
Status	Udgivet - 28 apr. 2020

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WJG-26-1971Forlagets udgivne version, 7,85 MBLicens: CC BY-NC

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Citationsformater

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title = "Severe steroid refractory gastritis induced by Nivolumab: A case report",

abstract = "BACKGROUND: Immune checkpoint inhibitors are widely used for treatment of many advanced malignancies. Lower gastrointestinal (GI) side effects, such as diarrhea and colitis, are common, but upper GI side effects are rarely reported. Consequently, the correct treatment of upper GI adverse events has been less frequently described.CASE SUMMARY: We describe a case of a 16-year-old woman with stage IIIb malignant melanoma treated with adjuvant monotherapy using Nivolumab. The patient developed severe gastritis after six series of Nivolumab with weight loss, nausea, and vomiting. There was no effect of intravenous steroids, but the patient´s condition resolved after administration of Infliximab.CONCLUSION: This case report supports the same treatment for gastritis as for colitis, which is in line with current guidelines.",

keywords = "Case report, Gastritis, Immune checkpoint inhibitors, Immune-related adverse events, Infliximab, Nivolumab",

author = "Vindum, {Helene Hjorth} and Agnholt, {J{\o}rgen S.} and Nielsen, {Anders Winther Moelby} and Nielsen, {Mette Bak} and Henrik Schmidt",

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doi = "10.3748/wjg.v26.i16.1971",

language = "English",

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Severe steroid refractory gastritis induced by Nivolumab: A case report. / Vindum, Helene Hjorth; Agnholt, Jørgen S.; Nielsen, Anders Winther Moelby et al.
I: World Journal of Gastroenterology, Bind 26, Nr. 16, 28.04.2020, s. 1971-1978.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Severe steroid refractory gastritis induced by Nivolumab

T2 - A case report

AU - Vindum, Helene Hjorth

AU - Agnholt, Jørgen S.

AU - Nielsen, Anders Winther Moelby

AU - Nielsen, Mette Bak

AU - Schmidt, Henrik

PY - 2020/4/28

Y1 - 2020/4/28

N2 - BACKGROUND: Immune checkpoint inhibitors are widely used for treatment of many advanced malignancies. Lower gastrointestinal (GI) side effects, such as diarrhea and colitis, are common, but upper GI side effects are rarely reported. Consequently, the correct treatment of upper GI adverse events has been less frequently described.CASE SUMMARY: We describe a case of a 16-year-old woman with stage IIIb malignant melanoma treated with adjuvant monotherapy using Nivolumab. The patient developed severe gastritis after six series of Nivolumab with weight loss, nausea, and vomiting. There was no effect of intravenous steroids, but the patient´s condition resolved after administration of Infliximab.CONCLUSION: This case report supports the same treatment for gastritis as for colitis, which is in line with current guidelines.

AB - BACKGROUND: Immune checkpoint inhibitors are widely used for treatment of many advanced malignancies. Lower gastrointestinal (GI) side effects, such as diarrhea and colitis, are common, but upper GI side effects are rarely reported. Consequently, the correct treatment of upper GI adverse events has been less frequently described.CASE SUMMARY: We describe a case of a 16-year-old woman with stage IIIb malignant melanoma treated with adjuvant monotherapy using Nivolumab. The patient developed severe gastritis after six series of Nivolumab with weight loss, nausea, and vomiting. There was no effect of intravenous steroids, but the patient´s condition resolved after administration of Infliximab.CONCLUSION: This case report supports the same treatment for gastritis as for colitis, which is in line with current guidelines.

KW - Case report

KW - Gastritis

KW - Immune checkpoint inhibitors

KW - Immune-related adverse events

KW - Infliximab

KW - Nivolumab

UR - http://www.scopus.com/inward/record.url?scp=85084396113&partnerID=8YFLogxK

U2 - 10.3748/wjg.v26.i16.1971

DO - 10.3748/wjg.v26.i16.1971

M3 - Journal article

C2 - 32390707

AN - SCOPUS:85084396113

SN - 1007-9327

VL - 26

SP - 1971

EP - 1978

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

IS - 16

ER -

Severe steroid refractory gastritis induced by Nivolumab: A case report

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