Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study

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Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study. / Goossens, G H; Petersen, Liselotte; Blaak, E E; Hul, G; Arner, P; Astrup, A; Froguel, P; Patel, K; Pedersen, O; Polak, J; Oppert, J-M; Martinez, J A; Sørensen, T I A; Saris, W H M; NUGENOB Consortium.

I: International Journal of Obesity, Bind 33, Nr. 6, 2009, s. 669-79.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Goossens, GH, Petersen, L, Blaak, EE, Hul, G, Arner, P, Astrup, A, Froguel, P, Patel, K, Pedersen, O, Polak, J, Oppert, J-M, Martinez, JA, Sørensen, TIA, Saris, WHM & NUGENOB Consortium 2009, 'Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study', International Journal of Obesity, bind 33, nr. 6, s. 669-79. https://doi.org/10.1038/ijo.2009.59

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CBE

Goossens GH, Petersen L, Blaak EE, Hul G, Arner P, Astrup A, Froguel P, Patel K, Pedersen O, Polak J, Oppert J-M, Martinez JA, Sørensen TIA, Saris WHM, NUGENOB Consortium. 2009. Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study. International Journal of Obesity. 33(6):669-79. https://doi.org/10.1038/ijo.2009.59

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Author

Goossens, G H ; Petersen, Liselotte ; Blaak, E E ; Hul, G ; Arner, P ; Astrup, A ; Froguel, P ; Patel, K ; Pedersen, O ; Polak, J ; Oppert, J-M ; Martinez, J A ; Sørensen, T I A ; Saris, W H M ; NUGENOB Consortium. / Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study. I: International Journal of Obesity. 2009 ; Bind 33, Nr. 6. s. 669-79.

Bibtex

@article{60fd1b90623611deb2cc000ea68e967b,
title = "Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study",
abstract = "BACKGROUND: Part of the heterogeneity of the obesity phenotype may originate from genetic differences between obese individuals that may influence energy expenditure (EE). OBJECTIVE: To examine if common single-nucleotide polymorphisms (SNPs) in genes related to obesity-associated phenotypes are associated with postabsorptive resting energy expenditure (REE) and postprandial REE in obese individuals. DESIGN AND METHODS: Postabsorptive REE and 3-h postprandial REE (liquid test meal containing 95{\%} fat, energy content 50{\%} of estimated REE) were measured in 743 obese individuals from eight clinical centres in seven European countries. The analysis assessed the association of genotypes of 44 SNPs in 28 obesity-related candidate genes with postabsorptive REE and postprandial REE taking into consideration the influence of body composition, habitual physical activity, insulin sensitivity, circulating thermogenic hormones and metabolites. RESULTS: After adjustment for fat-free mass (FFM), age, sex and research centre, SNPs in CART, GAD2, PCSK1, PPARG3, HSD11B1 and LIPC were significantly associated with postabsorptive REE. SNPs in GAD2, HSD11B1 and LIPC remained significantly associated with postabsorptive REE after further adjustment for fat mass (FM). SNPs in CART, PPARG2 and IGF2 were significantly associated with postprandial REE after similar adjustments. These associations with postprandial REE remained significant after further adjustment for FM. FTO, UCP2 and UCP3 variants were not associated with postabsorptive or postprandial REE. CONCLUSIONS: Several gene polymorphisms associated with obesity-related phenotypes but not FTO and UCP variants may be responsible for some of the inter-individual variability in postabsorptive REE and fat-induced thermogenesis unaccounted for by FFM, FM, age and sex. The association between FTO and obesity that has been reported earlier may not be mediated directly through modulation of EE in obese individuals.",
author = "Goossens, {G H} and Liselotte Petersen and Blaak, {E E} and G Hul and P Arner and A Astrup and P Froguel and K Patel and O Pedersen and J Polak and J-M Oppert and Martinez, {J A} and S{\o}rensen, {T I A} and Saris, {W H M} and {NUGENOB Consortium}",
year = "2009",
doi = "10.1038/ijo.2009.59",
language = "English",
volume = "33",
pages = "669--79",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",
number = "6",

}

RIS

TY - JOUR

T1 - Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study

AU - Goossens, G H

AU - Petersen, Liselotte

AU - Blaak, E E

AU - Hul, G

AU - Arner, P

AU - Astrup, A

AU - Froguel, P

AU - Patel, K

AU - Pedersen, O

AU - Polak, J

AU - Oppert, J-M

AU - Martinez, J A

AU - Sørensen, T I A

AU - Saris, W H M

AU - NUGENOB Consortium

PY - 2009

Y1 - 2009

N2 - BACKGROUND: Part of the heterogeneity of the obesity phenotype may originate from genetic differences between obese individuals that may influence energy expenditure (EE). OBJECTIVE: To examine if common single-nucleotide polymorphisms (SNPs) in genes related to obesity-associated phenotypes are associated with postabsorptive resting energy expenditure (REE) and postprandial REE in obese individuals. DESIGN AND METHODS: Postabsorptive REE and 3-h postprandial REE (liquid test meal containing 95% fat, energy content 50% of estimated REE) were measured in 743 obese individuals from eight clinical centres in seven European countries. The analysis assessed the association of genotypes of 44 SNPs in 28 obesity-related candidate genes with postabsorptive REE and postprandial REE taking into consideration the influence of body composition, habitual physical activity, insulin sensitivity, circulating thermogenic hormones and metabolites. RESULTS: After adjustment for fat-free mass (FFM), age, sex and research centre, SNPs in CART, GAD2, PCSK1, PPARG3, HSD11B1 and LIPC were significantly associated with postabsorptive REE. SNPs in GAD2, HSD11B1 and LIPC remained significantly associated with postabsorptive REE after further adjustment for fat mass (FM). SNPs in CART, PPARG2 and IGF2 were significantly associated with postprandial REE after similar adjustments. These associations with postprandial REE remained significant after further adjustment for FM. FTO, UCP2 and UCP3 variants were not associated with postabsorptive or postprandial REE. CONCLUSIONS: Several gene polymorphisms associated with obesity-related phenotypes but not FTO and UCP variants may be responsible for some of the inter-individual variability in postabsorptive REE and fat-induced thermogenesis unaccounted for by FFM, FM, age and sex. The association between FTO and obesity that has been reported earlier may not be mediated directly through modulation of EE in obese individuals.

AB - BACKGROUND: Part of the heterogeneity of the obesity phenotype may originate from genetic differences between obese individuals that may influence energy expenditure (EE). OBJECTIVE: To examine if common single-nucleotide polymorphisms (SNPs) in genes related to obesity-associated phenotypes are associated with postabsorptive resting energy expenditure (REE) and postprandial REE in obese individuals. DESIGN AND METHODS: Postabsorptive REE and 3-h postprandial REE (liquid test meal containing 95% fat, energy content 50% of estimated REE) were measured in 743 obese individuals from eight clinical centres in seven European countries. The analysis assessed the association of genotypes of 44 SNPs in 28 obesity-related candidate genes with postabsorptive REE and postprandial REE taking into consideration the influence of body composition, habitual physical activity, insulin sensitivity, circulating thermogenic hormones and metabolites. RESULTS: After adjustment for fat-free mass (FFM), age, sex and research centre, SNPs in CART, GAD2, PCSK1, PPARG3, HSD11B1 and LIPC were significantly associated with postabsorptive REE. SNPs in GAD2, HSD11B1 and LIPC remained significantly associated with postabsorptive REE after further adjustment for fat mass (FM). SNPs in CART, PPARG2 and IGF2 were significantly associated with postprandial REE after similar adjustments. These associations with postprandial REE remained significant after further adjustment for FM. FTO, UCP2 and UCP3 variants were not associated with postabsorptive or postprandial REE. CONCLUSIONS: Several gene polymorphisms associated with obesity-related phenotypes but not FTO and UCP variants may be responsible for some of the inter-individual variability in postabsorptive REE and fat-induced thermogenesis unaccounted for by FFM, FM, age and sex. The association between FTO and obesity that has been reported earlier may not be mediated directly through modulation of EE in obese individuals.

U2 - 10.1038/ijo.2009.59

DO - 10.1038/ijo.2009.59

M3 - Journal article

C2 - 19399022

VL - 33

SP - 669

EP - 679

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 6

ER -