Self-protection strategies and health behaviour in patients with inflammatory rheumatic diseases during the COVID-19 pandemic: Results and predictors in more than 12 000 patients with inflammatory rheumatic diseases followed in the Danish DANBIO registry

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DOI

  • Bente Glintborg, Københavns Universitet
  • ,
  • Dorte Vendelbo Jensen, Københavns Universitet
  • ,
  • Sara Engel, Københavns Universitet
  • ,
  • Lene Terslev, Københavns Universitet
  • ,
  • Mogens Pfeiffer Jensen, Københavns Universitet, Copenhagen Center for Arthritis Research (COPECARE)
  • ,
  • Oliver Hendricks, Syddansk Universitet
  • ,
  • Mikkel Ostergaard, Københavns Universitet
  • ,
  • Simon Horskjær Rasmussen, Københavns Universitet
  • ,
  • Thomas Adelsten, Sjællands Universitetshospital
  • ,
  • Ada Colic, Sjællands Universitetshospital
  • ,
  • Kamilla Danebod, Københavns Universitet
  • ,
  • Malene Kildemand, Syddansk Universitet
  • ,
  • Anne Gitte Loft
  • Heidi Lausten Munk, Syddansk Universitet
  • ,
  • Jens Kristian Pedersen, Syddansk Universitet
  • ,
  • René Drage Østgård
  • Christian Møller Sørensen, Aarhus Universitet
  • ,
  • Niels Steen Krogh, Zitelab Aps
  • ,
  • Jette Agerbo, Danish Rheumatism Association/Gigtforeningen
  • ,
  • Connie Ziegler, Danish Rheumatism Association/Gigtforeningen
  • ,
  • Merete Hetland, Københavns Universitet

Aims In Danish patients with inflammatory rheumatic diseases to explore self-protection strategies and health behaviour including adherence to disease-modifying antirheumatic treatment (DMARD) during the initial phase of the COVID-19 pandemic and again after the reopening of the society started. Furthermore, to identify characteristics of patients with high levels of anxiety and self-isolation. Methods Patients in routine care followed prospectively in the nationwide DANBIO registry were invited to answer an online questionnaire regarding disease activity and COVID-19 infection, behaviour in March and June 2020. Responses were linked to patient data in DANBIO. Characteristics potentially associated with anxiety, self-isolation and medication adherence (gender/age/diagnosis/education/work status/comorbidity/DMARD/smoking/EQ-5D/disease activity) were explored with multivariable logistic regression analyses. Results We included 12 789 patients (8168 rheumatoid arthritis/2068 psoriatic arthritis/1758 axial spondyloarthritis/795 other) of whom 65% were women and 36% treated with biological DMARD. Self-reported COVID-19 prevalence was 0.3%. Patients reported that they were worried to get COVID-19 infection (March/June: 70%/45%) and self-isolated more than others of the same age (48%/38%). The fraction of patients who changed medication due to fear of COVID-19 were 4.1%/0.6%. Female gender, comorbidities, not working, lower education, biological treatment and poor European Quality of life, 5 dimensions were associated with both anxiety and self-isolation. Conclusion In >12 000 patients with inflammatory arthritis, we found widespread anxiety and self-isolation, but high medication adherence, in the initial phase of the COVID-19 pandemic. This persisted during the gradual opening of society during the following months. Attention to patients' anxiety and self-isolation is important during this and potential future epidemics.

OriginalsprogEngelsk
Artikelnummer001505
TidsskriftRMD Open
Vol/bind7
Nummer1
Antal sider13
DOI
StatusUdgivet - jan. 2021

Bibliografisk note

Funding Information:
Funding Partly funded by an unrestricted grant from The Lundbeck Foundation (grant number R349-2020-629).

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Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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