Self-Detection of the LH Surge in Urine After GnRH Agonist Trigger in IVF: How to Minimize Failure to Retrieve Oocytes

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Self-Detection of the LH Surge in Urine After GnRH Agonist Trigger in IVF : How to Minimize Failure to Retrieve Oocytes. / Cozzolino, Mauro; Matey, Sonia; Alvarez, Abigail; Toribio, Mónica; López, Verónica; Perona, Marta; Henzenn, Elizabet; Piró, Manuel; Humaidan, Peter; Garcia-Velasco, Juan A.

I: Frontiers in Endocrinology, Bind 11, 221, 04.2020.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Cozzolino, M, Matey, S, Alvarez, A, Toribio, M, López, V, Perona, M, Henzenn, E, Piró, M, Humaidan, P & Garcia-Velasco, JA 2020, 'Self-Detection of the LH Surge in Urine After GnRH Agonist Trigger in IVF: How to Minimize Failure to Retrieve Oocytes', Frontiers in Endocrinology, bind 11, 221. https://doi.org/10.3389/fendo.2020.00221

APA

Cozzolino, M., Matey, S., Alvarez, A., Toribio, M., López, V., Perona, M., Henzenn, E., Piró, M., Humaidan, P., & Garcia-Velasco, J. A. (2020). Self-Detection of the LH Surge in Urine After GnRH Agonist Trigger in IVF: How to Minimize Failure to Retrieve Oocytes. Frontiers in Endocrinology, 11, [221]. https://doi.org/10.3389/fendo.2020.00221

CBE

Cozzolino M, Matey S, Alvarez A, Toribio M, López V, Perona M, Henzenn E, Piró M, Humaidan P, Garcia-Velasco JA. 2020. Self-Detection of the LH Surge in Urine After GnRH Agonist Trigger in IVF: How to Minimize Failure to Retrieve Oocytes. Frontiers in Endocrinology. 11:Article 221. https://doi.org/10.3389/fendo.2020.00221

MLA

Vancouver

Cozzolino M, Matey S, Alvarez A, Toribio M, López V, Perona M o.a. Self-Detection of the LH Surge in Urine After GnRH Agonist Trigger in IVF: How to Minimize Failure to Retrieve Oocytes. Frontiers in Endocrinology. 2020 apr;11. 221. https://doi.org/10.3389/fendo.2020.00221

Author

Cozzolino, Mauro ; Matey, Sonia ; Alvarez, Abigail ; Toribio, Mónica ; López, Verónica ; Perona, Marta ; Henzenn, Elizabet ; Piró, Manuel ; Humaidan, Peter ; Garcia-Velasco, Juan A. / Self-Detection of the LH Surge in Urine After GnRH Agonist Trigger in IVF : How to Minimize Failure to Retrieve Oocytes. I: Frontiers in Endocrinology. 2020 ; Bind 11.

Bibtex

@article{11f92f2ff7974f3080ac39c53c4f0d08,
title = "Self-Detection of the LH Surge in Urine After GnRH Agonist Trigger in IVF: How to Minimize Failure to Retrieve Oocytes",
abstract = "Research question: Urine LH testing may be useful to confirm an LH surge after the GnRH agonist (GnRHa) trigger prior to oocyte retrieval in IVF. Design: A prospective cohort study, including oocyte donors undergoing ovarian stimulation, treated with a GnRHa trigger for final oocyte maturation. Urine LH testing was performed at home, 12 h after the GnRHa trigger. In the case of a negative result, serum LH and progesterone measurements were done that same day. Donors with no serum LH peak after trigger were re-scheduled using a dual trigger, with GnRHa and hCG. Results: Three hundred and fifty nine oocyte donors were included in the analysis. Three hundred and fifty six donors had positive urine LH tests, followed by oocyte retrieval. In one case, the LH test was positive, however, no oocytes were retrieved (false positive 1/356). Three LH tests were negative in urine: in one of these three cases, LH was tested again in blood, confirming an LH rise, consistent with an optimal response to the GnRHa trigger; in the other two cases, serum LH was <15 mUI/mL, after which the oocyte retrieval was re-scheduled for 36 h after an being re-triggered, resulting in the retrieval of 19 and 22 MII oocytes, respectively. Considering the cost analysis, it would be a significantly cost-saving strategy, as blood testing would have costed 14,840€ vs. only 185.5€ in urine LH kits. Conclusions: Urinary testing of the LH surge after GnRHa trigger is easy, safe, reliable, and convenient. In addition, LH urine testing allows identifying donors and patients who could benefit from a rescue hCG trigger after an unsuccessful GnRHa trigger.",
keywords = "GnRH agonist, LH surge, oocyte retrieval, trigger, urinary test",
author = "Mauro Cozzolino and Sonia Matey and Abigail Alvarez and M{\'o}nica Toribio and Ver{\'o}nica L{\'o}pez and Marta Perona and Elizabet Henzenn and Manuel Pir{\'o} and Peter Humaidan and Garcia-Velasco, {Juan A.}",
year = "2020",
month = apr,
doi = "10.3389/fendo.2020.00221",
language = "English",
volume = "11",
journal = "Frontiers in Endocrinology",
issn = "1664-2392",
publisher = "Frontiers Media S.A",

}

RIS

TY - JOUR

T1 - Self-Detection of the LH Surge in Urine After GnRH Agonist Trigger in IVF

T2 - How to Minimize Failure to Retrieve Oocytes

AU - Cozzolino, Mauro

AU - Matey, Sonia

AU - Alvarez, Abigail

AU - Toribio, Mónica

AU - López, Verónica

AU - Perona, Marta

AU - Henzenn, Elizabet

AU - Piró, Manuel

AU - Humaidan, Peter

AU - Garcia-Velasco, Juan A.

PY - 2020/4

Y1 - 2020/4

N2 - Research question: Urine LH testing may be useful to confirm an LH surge after the GnRH agonist (GnRHa) trigger prior to oocyte retrieval in IVF. Design: A prospective cohort study, including oocyte donors undergoing ovarian stimulation, treated with a GnRHa trigger for final oocyte maturation. Urine LH testing was performed at home, 12 h after the GnRHa trigger. In the case of a negative result, serum LH and progesterone measurements were done that same day. Donors with no serum LH peak after trigger were re-scheduled using a dual trigger, with GnRHa and hCG. Results: Three hundred and fifty nine oocyte donors were included in the analysis. Three hundred and fifty six donors had positive urine LH tests, followed by oocyte retrieval. In one case, the LH test was positive, however, no oocytes were retrieved (false positive 1/356). Three LH tests were negative in urine: in one of these three cases, LH was tested again in blood, confirming an LH rise, consistent with an optimal response to the GnRHa trigger; in the other two cases, serum LH was <15 mUI/mL, after which the oocyte retrieval was re-scheduled for 36 h after an being re-triggered, resulting in the retrieval of 19 and 22 MII oocytes, respectively. Considering the cost analysis, it would be a significantly cost-saving strategy, as blood testing would have costed 14,840€ vs. only 185.5€ in urine LH kits. Conclusions: Urinary testing of the LH surge after GnRHa trigger is easy, safe, reliable, and convenient. In addition, LH urine testing allows identifying donors and patients who could benefit from a rescue hCG trigger after an unsuccessful GnRHa trigger.

AB - Research question: Urine LH testing may be useful to confirm an LH surge after the GnRH agonist (GnRHa) trigger prior to oocyte retrieval in IVF. Design: A prospective cohort study, including oocyte donors undergoing ovarian stimulation, treated with a GnRHa trigger for final oocyte maturation. Urine LH testing was performed at home, 12 h after the GnRHa trigger. In the case of a negative result, serum LH and progesterone measurements were done that same day. Donors with no serum LH peak after trigger were re-scheduled using a dual trigger, with GnRHa and hCG. Results: Three hundred and fifty nine oocyte donors were included in the analysis. Three hundred and fifty six donors had positive urine LH tests, followed by oocyte retrieval. In one case, the LH test was positive, however, no oocytes were retrieved (false positive 1/356). Three LH tests were negative in urine: in one of these three cases, LH was tested again in blood, confirming an LH rise, consistent with an optimal response to the GnRHa trigger; in the other two cases, serum LH was <15 mUI/mL, after which the oocyte retrieval was re-scheduled for 36 h after an being re-triggered, resulting in the retrieval of 19 and 22 MII oocytes, respectively. Considering the cost analysis, it would be a significantly cost-saving strategy, as blood testing would have costed 14,840€ vs. only 185.5€ in urine LH kits. Conclusions: Urinary testing of the LH surge after GnRHa trigger is easy, safe, reliable, and convenient. In addition, LH urine testing allows identifying donors and patients who could benefit from a rescue hCG trigger after an unsuccessful GnRHa trigger.

KW - GnRH agonist

KW - LH surge

KW - oocyte retrieval

KW - trigger

KW - urinary test

UR - http://www.scopus.com/inward/record.url?scp=85084342972&partnerID=8YFLogxK

U2 - 10.3389/fendo.2020.00221

DO - 10.3389/fendo.2020.00221

M3 - Journal article

C2 - 32390942

AN - SCOPUS:85084342972

VL - 11

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

SN - 1664-2392

M1 - 221

ER -