Self-assembled nanoparticles of glycol chitosan – Ergocalciferol succinate conjugate, for controlled release

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Self-assembled nanoparticles of glycol chitosan – Ergocalciferol succinate conjugate, for controlled release. / Quinones, Javier Perez; Gothelf, Kurt Vesterager; Kjems, Jørgen; Caballero, Angeles Maria Hevas ; Schmidt, Claudia; Covas, Carlos Peniche.

I: Carbohydrate Polymers, Bind 88, Nr. 4, 16.05.2012, s. 1373-1377.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Quinones, Javier Perez ; Gothelf, Kurt Vesterager ; Kjems, Jørgen ; Caballero, Angeles Maria Hevas ; Schmidt, Claudia ; Covas, Carlos Peniche. / Self-assembled nanoparticles of glycol chitosan – Ergocalciferol succinate conjugate, for controlled release. I: Carbohydrate Polymers. 2012 ; Bind 88, Nr. 4. s. 1373-1377.

Bibtex

@article{3a032461e786400180be3a95115ce270,
title = "Self-assembled nanoparticles of glycol chitosan – Ergocalciferol succinate conjugate, for controlled release",
abstract = "Glycol chitosan was linked to vitamin D2 hemisuccinate (ergocalciferol hemisuccinate) for controlled release through water-soluble carbodiimide activation. The resulting conjugate formed self-assembled nanoparticles in aqueous solution with particle size of 279 nm and ergocalciferol hemisuccinate content of 8.4{\%} (w/w). Almost spherical 50–90 nm nanoparticles were observed by scanning and transmission electron microscopy upon drying. Drug linking to glycol chitosan was confirmed by FTIR spectroscopy and proton NMR. Particles were also characterized by differential scanning calorimetry and wide-angle X-ray diffraction studies. In vitro vitamin D2 release studies performed in water at acid pH indicated a drug release dependence on the solution acidity. Almost constant release rate was observed during the first 8 h. These results indicate that the obtained nanoparticles could be good candidates for vitamin D2 release to animals and humans.",
keywords = "Controlled release, Glycol chitosan, Nanoparticles, Vitamin D2",
author = "Quinones, {Javier Perez} and Gothelf, {Kurt Vesterager} and J{\o}rgen Kjems and Caballero, {Angeles Maria Hevas} and Claudia Schmidt and Covas, {Carlos Peniche}",
year = "2012",
month = "5",
day = "16",
doi = "10.1016/j.carbpol.2012.02.039",
language = "English",
volume = "88",
pages = "1373--1377",
journal = "Carbohydrate Polymers",
issn = "0144-8617",
publisher = "Pergamon Press",
number = "4",

}

RIS

TY - JOUR

T1 - Self-assembled nanoparticles of glycol chitosan – Ergocalciferol succinate conjugate, for controlled release

AU - Quinones, Javier Perez

AU - Gothelf, Kurt Vesterager

AU - Kjems, Jørgen

AU - Caballero, Angeles Maria Hevas

AU - Schmidt, Claudia

AU - Covas, Carlos Peniche

PY - 2012/5/16

Y1 - 2012/5/16

N2 - Glycol chitosan was linked to vitamin D2 hemisuccinate (ergocalciferol hemisuccinate) for controlled release through water-soluble carbodiimide activation. The resulting conjugate formed self-assembled nanoparticles in aqueous solution with particle size of 279 nm and ergocalciferol hemisuccinate content of 8.4% (w/w). Almost spherical 50–90 nm nanoparticles were observed by scanning and transmission electron microscopy upon drying. Drug linking to glycol chitosan was confirmed by FTIR spectroscopy and proton NMR. Particles were also characterized by differential scanning calorimetry and wide-angle X-ray diffraction studies. In vitro vitamin D2 release studies performed in water at acid pH indicated a drug release dependence on the solution acidity. Almost constant release rate was observed during the first 8 h. These results indicate that the obtained nanoparticles could be good candidates for vitamin D2 release to animals and humans.

AB - Glycol chitosan was linked to vitamin D2 hemisuccinate (ergocalciferol hemisuccinate) for controlled release through water-soluble carbodiimide activation. The resulting conjugate formed self-assembled nanoparticles in aqueous solution with particle size of 279 nm and ergocalciferol hemisuccinate content of 8.4% (w/w). Almost spherical 50–90 nm nanoparticles were observed by scanning and transmission electron microscopy upon drying. Drug linking to glycol chitosan was confirmed by FTIR spectroscopy and proton NMR. Particles were also characterized by differential scanning calorimetry and wide-angle X-ray diffraction studies. In vitro vitamin D2 release studies performed in water at acid pH indicated a drug release dependence on the solution acidity. Almost constant release rate was observed during the first 8 h. These results indicate that the obtained nanoparticles could be good candidates for vitamin D2 release to animals and humans.

KW - Controlled release

KW - Glycol chitosan

KW - Nanoparticles

KW - Vitamin D2

U2 - 10.1016/j.carbpol.2012.02.039

DO - 10.1016/j.carbpol.2012.02.039

M3 - Journal article

VL - 88

SP - 1373

EP - 1377

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

SN - 0144-8617

IS - 4

ER -