Self-assembled nanoparticles of modified-chitosan conjugates for the sustained release of dl-α-tocopherol

TY - JOUR

T1 - Self-assembled nanoparticles of modified-chitosan conjugates for the sustained release of dl-α-tocopherol

AU - Quinones, Javier Perez

AU - Gothelf, Kurt Vesterager

AU - Kjems, Jørgen

AU - Yang, Chuanxu

AU - Caballero, Angeles Maria Heras

AU - Schmidt, Claudia

AU - Peniche Covas, Carlos

PY - 2013/1/30

Y1 - 2013/1/30

N2 - Synthetic O6-succinylated chitosan and commercial glycol chitosan were covalently linked to dl-α-tocopheryl monoesters for controlled release of vitamin E. These conjugates formed self-assembled nanoparticles in aqueous solution with 254–496 nm mean diameters and dl-α-tocopherol contents between 27 and 39% (w/w). The particles appeared as 40–75 nm almost spherical nanoparticles when studied by scanning and transmission electron microscopy upon drying. Drug linking to chitosan matrix was confirmed by FTIR spectroscopy and proton NMR. Conjugates were also characterized by differential scanning calorimetry and wide-angle X-ray diffraction. In vitro tocopherol release studies performed in water at acid pH indicated a drug release dependence on drug content, hydrated particle sizes and employed chitosan derivative. Almost constant release rates were observed the first 7 h. The obtained nanoparticles exhibited radical scavenging activity in DPPH essay. The potential of these nanoparticles was also demonstrated by the enhancement of HMVEC cell proliferation

AB - Synthetic O6-succinylated chitosan and commercial glycol chitosan were covalently linked to dl-α-tocopheryl monoesters for controlled release of vitamin E. These conjugates formed self-assembled nanoparticles in aqueous solution with 254–496 nm mean diameters and dl-α-tocopherol contents between 27 and 39% (w/w). The particles appeared as 40–75 nm almost spherical nanoparticles when studied by scanning and transmission electron microscopy upon drying. Drug linking to chitosan matrix was confirmed by FTIR spectroscopy and proton NMR. Conjugates were also characterized by differential scanning calorimetry and wide-angle X-ray diffraction. In vitro tocopherol release studies performed in water at acid pH indicated a drug release dependence on drug content, hydrated particle sizes and employed chitosan derivative. Almost constant release rates were observed the first 7 h. The obtained nanoparticles exhibited radical scavenging activity in DPPH essay. The potential of these nanoparticles was also demonstrated by the enhancement of HMVEC cell proliferation

U2 - 10.1016/j.carbpol.2012.10.005

DO - 10.1016/j.carbpol.2012.10.005

M3 - Journal article

C2 - 23218376

SN - 0144-8617

VL - 92

SP - 856

EP - 864

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

IS - 1

ER -