Selective Sweeps Under Dominance and Inbreeding

TY - JOUR

T1 - Selective Sweeps Under Dominance and Inbreeding

AU - Hartfield, Matthew

AU - Bataillon, Thomas

PY - 2020/3

Y1 - 2020/3

N2 - A major research goal in evolutionary genetics is to uncover loci experiencing positive selection. One approach involves finding 'selective sweeps' patterns, which can either be 'hard sweeps' formed by de novo mutation, or 'soft sweeps' arising from recurrent mutation or existing standing variation. Existing theory generally assumes outcrossing populations, and it is unclear how dominance affects soft sweeps. We consider how arbitrary dominance and inbreeding via self-fertilization affect hard and soft sweep signatures. With increased self-fertilization, they are maintained over longer map distances due to reduced effective recombination and faster beneficial allele fixation times. Dominance can affect sweep patterns in outcrossers if the derived variant originates from either a single novel allele, or from recurrent mutation. These models highlight the challenges in distinguishing hard and soft sweeps, and propose methods to differentiate between scenarios.

AB - A major research goal in evolutionary genetics is to uncover loci experiencing positive selection. One approach involves finding 'selective sweeps' patterns, which can either be 'hard sweeps' formed by de novo mutation, or 'soft sweeps' arising from recurrent mutation or existing standing variation. Existing theory generally assumes outcrossing populations, and it is unclear how dominance affects soft sweeps. We consider how arbitrary dominance and inbreeding via self-fertilization affect hard and soft sweep signatures. With increased self-fertilization, they are maintained over longer map distances due to reduced effective recombination and faster beneficial allele fixation times. Dominance can affect sweep patterns in outcrossers if the derived variant originates from either a single novel allele, or from recurrent mutation. These models highlight the challenges in distinguishing hard and soft sweeps, and propose methods to differentiate between scenarios.

KW - Adaptation

KW - Dominance

KW - Population Genetics

KW - Selective Sweeps

KW - Self-fertilisation

UR - http://www.scopus.com/inward/record.url?scp=85081944530&partnerID=8YFLogxK

U2 - 10.1534/g3.119.400919

DO - 10.1534/g3.119.400919

M3 - Journal article

C2 - 31974096

AN - SCOPUS:85081944530

SN - 2160-1836

VL - 10

SP - 1063

EP - 1075

JO - G3 (Bethesda, Md.)

JF - G3 (Bethesda, Md.)

IS - 3

ER -