Selective serotonin reuptake inhibitors and risk of epilepsy after traumatic brain injury – A population based cohort study

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Selective serotonin reuptake inhibitors and risk of epilepsy after traumatic brain injury – A population based cohort study. / Christensen, Jakob; Pedersen, Henrik Schou; Fenger-Grøn, Morten; Fann, Jesse R.; Jones, Nigel C.; Vestergaard, Mogens.

I: PLOS ONE, Bind 14, Nr. 7, e0219137, 07.2019.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{0f3213d2780040c293d08381b478d42f,
title = "Selective serotonin reuptake inhibitors and risk of epilepsy after traumatic brain injury – A population based cohort study",
abstract = "Objective Traumatic brain injury (TBI) is common and associated with a marked increased risk of developing epilepsy. Animal studies indicate that treatment with selective serotonin reuptake inhibitors (SSRIs) may increase the risk of epilepsy after TBI. The aim of this study was to investigate whether use of SSRIs modifies the risk of epilepsy after TBI. Methods This was a cohort study of 205,715 persons, who suffered a TBI in Denmark from 1996 to 2013. For each person with TBI, we matched 10 reference persons (N = 2,057,150) who were alive on the day of TBI and who had the same age and gender but had no history of TBI. We used a stratified Cox regression to calculate the relative risk of epilepsy after TBI for persons exposed to TBI, SSRI or both after adjustment for income, civil status, medical and neurological comorbidities, severe mental disease, and substance abuse. Results The risk of epilepsy was 5.61 times higher for persons who used SSRI at time of TBI (adjusted Hazard Ratio (aHR): 5.61 (95% CI: 4.88; 6.45)), 3.23 times higher for persons who had a TBI but did not use SSRI at time of TBI (aHR: 3.23 (95% CI: 3.12;3.35)), and 1.31 times higher for persons who used SSRI but had no TBI (aHR: 1.31 (95% CI: 1.18; 1.45)) compared to persons unexposed to both TBI and SSRI. Conclusions This large population based cohort study showed that people using SSRI at the time of a TBI had higher risk of developing epilepsy compared to people not using SSRI at the time of TBI. The results are in line with those of animal studies and calls for further studies to evaluate whether the association is due to SSRIs or to the underlying disease (e.g. depression or anxiety).",
keywords = "ANTIDEPRESSANTS, ASSOCIATION, COMORBIDITIES, DISORDERS, DRUGS, EPILEPTOGENESIS, MAJOR DEPRESSION, SEIZURES, SERTRALINE",
author = "Jakob Christensen and Pedersen, {Henrik Schou} and Morten Fenger-Gr{\o}n and Fann, {Jesse R.} and Jones, {Nigel C.} and Mogens Vestergaard",
year = "2019",
month = jul,
doi = "10.1371/journal.pone.0219137",
language = "English",
volume = "14",
journal = "P L o S One",
issn = "1932-6203",
publisher = "public library of science",
number = "7",

}

RIS

TY - JOUR

T1 - Selective serotonin reuptake inhibitors and risk of epilepsy after traumatic brain injury – A population based cohort study

AU - Christensen, Jakob

AU - Pedersen, Henrik Schou

AU - Fenger-Grøn, Morten

AU - Fann, Jesse R.

AU - Jones, Nigel C.

AU - Vestergaard, Mogens

PY - 2019/7

Y1 - 2019/7

N2 - Objective Traumatic brain injury (TBI) is common and associated with a marked increased risk of developing epilepsy. Animal studies indicate that treatment with selective serotonin reuptake inhibitors (SSRIs) may increase the risk of epilepsy after TBI. The aim of this study was to investigate whether use of SSRIs modifies the risk of epilepsy after TBI. Methods This was a cohort study of 205,715 persons, who suffered a TBI in Denmark from 1996 to 2013. For each person with TBI, we matched 10 reference persons (N = 2,057,150) who were alive on the day of TBI and who had the same age and gender but had no history of TBI. We used a stratified Cox regression to calculate the relative risk of epilepsy after TBI for persons exposed to TBI, SSRI or both after adjustment for income, civil status, medical and neurological comorbidities, severe mental disease, and substance abuse. Results The risk of epilepsy was 5.61 times higher for persons who used SSRI at time of TBI (adjusted Hazard Ratio (aHR): 5.61 (95% CI: 4.88; 6.45)), 3.23 times higher for persons who had a TBI but did not use SSRI at time of TBI (aHR: 3.23 (95% CI: 3.12;3.35)), and 1.31 times higher for persons who used SSRI but had no TBI (aHR: 1.31 (95% CI: 1.18; 1.45)) compared to persons unexposed to both TBI and SSRI. Conclusions This large population based cohort study showed that people using SSRI at the time of a TBI had higher risk of developing epilepsy compared to people not using SSRI at the time of TBI. The results are in line with those of animal studies and calls for further studies to evaluate whether the association is due to SSRIs or to the underlying disease (e.g. depression or anxiety).

AB - Objective Traumatic brain injury (TBI) is common and associated with a marked increased risk of developing epilepsy. Animal studies indicate that treatment with selective serotonin reuptake inhibitors (SSRIs) may increase the risk of epilepsy after TBI. The aim of this study was to investigate whether use of SSRIs modifies the risk of epilepsy after TBI. Methods This was a cohort study of 205,715 persons, who suffered a TBI in Denmark from 1996 to 2013. For each person with TBI, we matched 10 reference persons (N = 2,057,150) who were alive on the day of TBI and who had the same age and gender but had no history of TBI. We used a stratified Cox regression to calculate the relative risk of epilepsy after TBI for persons exposed to TBI, SSRI or both after adjustment for income, civil status, medical and neurological comorbidities, severe mental disease, and substance abuse. Results The risk of epilepsy was 5.61 times higher for persons who used SSRI at time of TBI (adjusted Hazard Ratio (aHR): 5.61 (95% CI: 4.88; 6.45)), 3.23 times higher for persons who had a TBI but did not use SSRI at time of TBI (aHR: 3.23 (95% CI: 3.12;3.35)), and 1.31 times higher for persons who used SSRI but had no TBI (aHR: 1.31 (95% CI: 1.18; 1.45)) compared to persons unexposed to both TBI and SSRI. Conclusions This large population based cohort study showed that people using SSRI at the time of a TBI had higher risk of developing epilepsy compared to people not using SSRI at the time of TBI. The results are in line with those of animal studies and calls for further studies to evaluate whether the association is due to SSRIs or to the underlying disease (e.g. depression or anxiety).

KW - ANTIDEPRESSANTS

KW - ASSOCIATION

KW - COMORBIDITIES

KW - DISORDERS

KW - DRUGS

KW - EPILEPTOGENESIS

KW - MAJOR DEPRESSION

KW - SEIZURES

KW - SERTRALINE

UR - http://www.scopus.com/inward/record.url?scp=85069682283&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0219137

DO - 10.1371/journal.pone.0219137

M3 - Journal article

C2 - 31323024

AN - SCOPUS:85069682283

VL - 14

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 7

M1 - e0219137

ER -