Selective enhancement of radiation response in a C3H mammary carcinoma by cisplatin

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The interaction between cisplatin and radiation was studied in a C3H mammary carcinoma and its surrounding normal skin. Treatment with 6 mg/kg of cisplatin given 30 mins before irradiation enhanced the radiation response in the tumor by a factor of 1.7, whereas the same drug treatment given immediately after or 4 hrs after irradiation only enhanced the effect by a factor of 1.2--1.3. No interaction between radiation and cisplatin was observed in the surrounding skin. It is hypothesized that in the C3H mammary carcinoma the prominent radiation-modifying effect of cisplatin given before radiation is due to a radiosensitization involving hypoxic tumor cells combined with a tumor cell-destructive effect of the drug itself.
OriginalsprogEngelsk
TidsskriftCancer Treatment Reports
Vol/bind65
Nummer5-6
Sider (fra-til)501-503
Antal sider3
ISSN0361-5960
StatusUdgivet - 1981

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