SELECTIVE C-2 AND C-4 DEACYLATION AND ACYLATION OF TAXOL - THE FIRST SYNTHESIS OF A C-4 SUBSTITUTED TAXOL ANALOG

GI GEORG*, SM ALI, TC BOGE, A DATTA, L FALBORG, RH HIMES

*Corresponding author af dette arbejde

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Abstract

Hydrolytic procedures for selective 2-debenzoylation and 2,4-dideacylation of 2'-0-tert-butyldimethylsilyl-7-0-(triethylsilyl)taxol are reported. The first synthesis and biological evaluation of a 4-substituted analogue, 4-deacetyl-4-isobutanoyltaxol, is presented. The chemistry described in this letter is suitable for the facile synthesis of taxol congeners modified at C-2 and/or C-4.

OriginalsprogEngelsk
TidsskriftTetrahedron Letters
Vol/bind35
Nummer48
Sider (fra-til)8931-8934
Antal sider4
ISSN0040-4039
StatusUdgivet - 28 nov. 1994

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