Secretin: a hormone for HCO3− homeostasis

Peder Berg; Samuel L. Svendsen; Niklas Ayasse; Mads Vaarby Sorensen; Jens Leipziger

doi:10.1007/s00424-024-02906-3

Secretin: a hormone for HCO3− homeostasis

Peder Berg, Samuel L. Svendsen, Niklas Ayasse, Mads Vaarby Sorensen, Jens Leipziger

Institut for Biomedicin - Forskning og uddannelse, Skou-bygningen

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review

7 Citationer (Scopus)

Abstract

Secretin is a key hormone of the intestinal phase of digestion which activates pancreatic, bile duct and Brunner gland HCO3− secretion. Recently, the secretin receptor (SCTR) was also found in the basolateral membrane of the beta-intercalated cell (B-IC) of the collecting duct. Experimental addition of secretin triggers a pronounced activation of urinary HCO3− excretion, which is fully dependent on key functional proteins of the B-IC, namely apical pendrin and CFTR and the basolateral SCTR. Recent studies demonstrated that the SCTR knock-out mouse is unable to respond to an acute base load. Here, SCTR KO mice could not rapidly increase urine base excretion, developed prolonged metabolic alkalosis and exhibited marked compensatory hypoventilation. Here, we review the physiological effects of secretin with distinct focus on how secretin activates renal HCO3− excretion. We describe its new function as a hormone for HCO3− homeostasis.

Originalsprog	Engelsk
Tidsskrift	Pflügers Archiv - European Journal of Physiology
Vol/bind	476
Nummer	4
Sider (fra-til)	545-554
Antal sider	10
ISSN	1432-2013
DOI	https://doi.org/10.1007/s00424-024-02906-3
Status	Udgivet - apr. 2024

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Citationsformater

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abstract = "Secretin is a key hormone of the intestinal phase of digestion which activates pancreatic, bile duct and Brunner gland HCO3− secretion. Recently, the secretin receptor (SCTR) was also found in the basolateral membrane of the beta-intercalated cell (B-IC) of the collecting duct. Experimental addition of secretin triggers a pronounced activation of urinary HCO3− excretion, which is fully dependent on key functional proteins of the B-IC, namely apical pendrin and CFTR and the basolateral SCTR. Recent studies demonstrated that the SCTR knock-out mouse is unable to respond to an acute base load. Here, SCTR KO mice could not rapidly increase urine base excretion, developed prolonged metabolic alkalosis and exhibited marked compensatory hypoventilation. Here, we review the physiological effects of secretin with distinct focus on how secretin activates renal HCO3− excretion. We describe its new function as a hormone for HCO3− homeostasis.",

keywords = "Beta intercalated cell, Collecting duct, HCO3- secretion, Hormone, Kidney",

author = "Peder Berg and Svendsen, {Samuel L.} and Niklas Ayasse and Sorensen, {Mads Vaarby} and Jens Leipziger",

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T1 - Secretin: a hormone for HCO3− homeostasis

AU - Berg, Peder

AU - Svendsen, Samuel L.

AU - Ayasse, Niklas

AU - Sorensen, Mads Vaarby

AU - Leipziger, Jens

PY - 2024/4

Y1 - 2024/4

N2 - Secretin is a key hormone of the intestinal phase of digestion which activates pancreatic, bile duct and Brunner gland HCO3− secretion. Recently, the secretin receptor (SCTR) was also found in the basolateral membrane of the beta-intercalated cell (B-IC) of the collecting duct. Experimental addition of secretin triggers a pronounced activation of urinary HCO3− excretion, which is fully dependent on key functional proteins of the B-IC, namely apical pendrin and CFTR and the basolateral SCTR. Recent studies demonstrated that the SCTR knock-out mouse is unable to respond to an acute base load. Here, SCTR KO mice could not rapidly increase urine base excretion, developed prolonged metabolic alkalosis and exhibited marked compensatory hypoventilation. Here, we review the physiological effects of secretin with distinct focus on how secretin activates renal HCO3− excretion. We describe its new function as a hormone for HCO3− homeostasis.

AB - Secretin is a key hormone of the intestinal phase of digestion which activates pancreatic, bile duct and Brunner gland HCO3− secretion. Recently, the secretin receptor (SCTR) was also found in the basolateral membrane of the beta-intercalated cell (B-IC) of the collecting duct. Experimental addition of secretin triggers a pronounced activation of urinary HCO3− excretion, which is fully dependent on key functional proteins of the B-IC, namely apical pendrin and CFTR and the basolateral SCTR. Recent studies demonstrated that the SCTR knock-out mouse is unable to respond to an acute base load. Here, SCTR KO mice could not rapidly increase urine base excretion, developed prolonged metabolic alkalosis and exhibited marked compensatory hypoventilation. Here, we review the physiological effects of secretin with distinct focus on how secretin activates renal HCO3− excretion. We describe its new function as a hormone for HCO3− homeostasis.

KW - Beta intercalated cell

KW - Collecting duct

KW - HCO3- secretion

KW - Hormone

KW - Kidney

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DO - 10.1007/s00424-024-02906-3

M3 - Review

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VL - 476

SP - 545

EP - 554

JO - Pflügers Archiv - European Journal of Physiology

JF - Pflügers Archiv - European Journal of Physiology

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