Second-hand smoke exposure in adulthood and lower respiratory health during 20 year follow up in the European Community Respiratory Health Survey

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  • Claudia Flexeder, Helmholtz Zentrum München - German Research Center for Environmental Health
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  • Jan Paul Zock, Barcelona Institute for Global Health, Universitat Pompeu Fabra, Barcelona, Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP)
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  • Deborah Jarvis, Imperial College London, London, UK., National Heart and Lung Institute
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  • Giuseppe Verlato, University of Verona
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  • Mario Olivieri, University Hospital Verona
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  • Geza Benke, Monash University
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  • Michael J. Abramson, Monash University
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  • Torben Sigsgaard
  • Cecilie Svanes, Universitetet i Bergen, Department of Occupational Medicine, Haukeland University Hospital, NO-5021 Bergen, Norway. tor.aasen@helse-bergen.no.
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  • Kjell Torén, Gøteborg Transplantationscenter, Sahlgrenska Universitetssjukhuset
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  • Dennis Nowak, Klinikum Grosshaden, Member of the German Center for Lung Research (DZL)
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  • Rain Jõgi, Tartu University Clinics
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  • Jesús Martinez-Moratalla, Albacete University Hospital, Universidad de Castilla - la Mancha
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  • Pascal Demoly, univ Montpellier, Inserm
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  • Christer Janson, Uppsala universitet
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  • Thorarinn Gislason, Landspitali National University Hospital of Iceland, University of Iceland
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  • Roberto Bono, Università degli Studi di Torino
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  • Mathias Holm, Clinical Sciences, Umea universitet, Klinisk vetenskap.
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  • Karl A. Franklin, Department of Integrated Structural Biology, IGBMC (Institute of Genetics and of Molecular and Cellular Biology), Centre National de la Recherche Scientifique (CNRS) UMR 7104/Institut National de la Santé de la Recherche Médicale (INSERM) U964/Université de Strasbourg
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  • Judith Garcia-Aymerich, Barcelona Institute for Global Health, Universitat Pompeu Fabra, Barcelona, Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP)
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  • Valérie Siroux, Université Paris—Denis Diderot
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  • Bénédicte Leynaert, Galdakao-Usansolo Hospital
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  • Sandra Dorado Arenas, IRCCS Policlinico S. Matteo Foundation
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  • Angelo Guido Corsico, Università Degli Studi di Pavia, Respiratory and Allergy Clinical Unit
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  • Antonio Pereira-Vega, Swiss Tropical and Public Health Institute (Swiss TPH)
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  • Nicole Probst-Hensch, University of Basel, Galdakao Hospital
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  • Isabel Urrutia Landa, Melbourne School of Population and Global Health
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  • Holger Schulz, Helmholtz Zentrum München - German Research Center for Environmental Health, Member of the German Center for Lung Research (DZL)
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  • Joachim Heinrich, Helmholtz Zentrum München - German Research Center for Environmental Health, Klinikum Grosshaden, Melbourne School of Population and Global Health

Background: Early life exposure to tobacco smoke has been extensively studied but the role of second-hand smoke (SHS) for new-onset respiratory symptoms and lung function decline in adulthood has not been widely investigated in longitudinal studies. Our aim is to investigate the associations of exposure to SHS in adults with respiratory symptoms, respiratory conditions and lung function over 20 years. Methods: We used information from 3011 adults from 26 centres in 12 countries who participated in the European Community Respiratory Health Surveys I-III and were never or former smokers at all three surveys. Associations of SHS exposure with respiratory health (asthma symptom score, asthma, chronic bronchitis, COPD) were analysed using generalised linear mixed-effects models adjusted for confounding factors (including sex, age, smoking status, socioeconomic status and allergic sensitisation). Linear mixed-effects models with additional adjustment for height were used to assess the relationships between SHS exposure and lung function levels and decline. Results: Reported exposure to SHS decreased in all 26 study centres over time. The prevalence of SHS exposure was 38.7% at baseline (1990-1994) and 7.1% after the 20-year follow-up (2008-2011). On average 2.4% of the study participants were not exposed at the first, but were exposed at the third examination. An increase in SHS exposure over time was associated with doctor-diagnosed asthma (odds ratio (OR): 2.7; 95% confidence interval (95%-CI): 1.2-5.9), chronic bronchitis (OR: 4.8; 95%-CI: 1.6-15.0), asthma symptom score (count ratio (CR): 1.9; 95%-CI: 1.2-2.9) and dyspnoea (OR: 2.7; 95%-CI: 1.1-6.7) compared to never exposed to SHS. Associations between increase in SHS exposure and incidence of COPD (OR: 2.0; 95%-CI: 0.6-6.0) or lung function (β: - 49 ml; 95%-CI: -132, 35 for FEV1 and β: - 62 ml; 95%-CI: -165, 40 for FVC) were not apparent. Conclusion: Exposure to second-hand smoke may lead to respiratory symptoms, but this is not accompanied by lung function changes.

OriginalsprogEngelsk
Artikelnummer33
TidsskriftRespiratory Research
Vol/bind20
Nummer1
Antal sider15
ISSN1465-9921
DOI
StatusUdgivet - 2019

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