Seasonal variation in the hypertensive disorders of pregnancy in Denmark

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Seasonal variation in the hypertensive disorders of pregnancy in Denmark. / Rohr Thomsen (Antonsen), Christine; Henriksen, Tine Brink; Uldbjerg, Niels; Milidou, Ioanna.

I: Acta Obstetricia et Gynecologica Scandinavica, Bind 99, Nr. 5, 05.2020, s. 623-630.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{1a556ffdf0a14ec49dcf4b27cb1e9317,
title = "Seasonal variation in the hypertensive disorders of pregnancy in Denmark",
abstract = "Introduction: Hypertensive disorders of pregnancy, including gestational hypertension and preeclampsia, are leading causes of morbidity and mortality for both mother and fetus. It has been proposed that vitamin D affects a number of biological processes involved in the pathogenesis of hypertensive disorders of pregnancy. Therefore, a seasonal variation in the risk of these disorders might be expected in areas such as Denmark with marked seasonal variation in sunlight exposure. In this study, we aimed to evaluate the existence of this association. Material and methods: We used information from a cohort of 50 665 previously healthy, nulliparous women with singleton pregnancies. All women gave birth between 1989 and 2010 at Aarhus University Hospital, Denmark. Logistic regression analyses combined with the cubic spline method were used to estimate the seasonal variation for each outcome: gestational hypertension and preeclampsia, after adjusting for calendar time. Results: Of the 50 665 women included, 8.5% were diagnosed with a hypertensive disorder of pregnancy. The overall tendency was towards increasing risk when conceiving during spring and early summer, peaking midsummer, and subsequently decreasing steadily during late summer and fall to reach the nadir by winter. Seasonal variation was found for; gestational hypertension (P =.01); preeclampsia (P =.001) and early-onset preeclampsia (P =.014). Conclusions: We found a seasonal variation in the risk of the hypertensive disorders of pregnancy in a large cohort of Danish nulliparous women. The highest risk was seen in women with the estimated date of conception in June and August, that is, during summer. Seasonal variation in vitamin D status may explain this association.",
keywords = "early-onset preeclampsia, gestational hypertension, hypertensive disorders of pregnancy, preeclampsia, seasons, vitamin D, VITAMIN-D, PREECLAMPSIA, PREVALENCE",
author = "{Rohr Thomsen (Antonsen)}, Christine and Henriksen, {Tine Brink} and Niels Uldbjerg and Ioanna Milidou",
year = "2020",
month = may,
doi = "10.1111/aogs.13786",
language = "English",
volume = "99",
pages = "623--630",
journal = "Acta Obstetricia et Gynecologica Scandinavica",
issn = "0001-6349",
publisher = "JohnWiley & Sons Ltd.",
number = "5",

}

RIS

TY - JOUR

T1 - Seasonal variation in the hypertensive disorders of pregnancy in Denmark

AU - Rohr Thomsen (Antonsen), Christine

AU - Henriksen, Tine Brink

AU - Uldbjerg, Niels

AU - Milidou, Ioanna

PY - 2020/5

Y1 - 2020/5

N2 - Introduction: Hypertensive disorders of pregnancy, including gestational hypertension and preeclampsia, are leading causes of morbidity and mortality for both mother and fetus. It has been proposed that vitamin D affects a number of biological processes involved in the pathogenesis of hypertensive disorders of pregnancy. Therefore, a seasonal variation in the risk of these disorders might be expected in areas such as Denmark with marked seasonal variation in sunlight exposure. In this study, we aimed to evaluate the existence of this association. Material and methods: We used information from a cohort of 50 665 previously healthy, nulliparous women with singleton pregnancies. All women gave birth between 1989 and 2010 at Aarhus University Hospital, Denmark. Logistic regression analyses combined with the cubic spline method were used to estimate the seasonal variation for each outcome: gestational hypertension and preeclampsia, after adjusting for calendar time. Results: Of the 50 665 women included, 8.5% were diagnosed with a hypertensive disorder of pregnancy. The overall tendency was towards increasing risk when conceiving during spring and early summer, peaking midsummer, and subsequently decreasing steadily during late summer and fall to reach the nadir by winter. Seasonal variation was found for; gestational hypertension (P =.01); preeclampsia (P =.001) and early-onset preeclampsia (P =.014). Conclusions: We found a seasonal variation in the risk of the hypertensive disorders of pregnancy in a large cohort of Danish nulliparous women. The highest risk was seen in women with the estimated date of conception in June and August, that is, during summer. Seasonal variation in vitamin D status may explain this association.

AB - Introduction: Hypertensive disorders of pregnancy, including gestational hypertension and preeclampsia, are leading causes of morbidity and mortality for both mother and fetus. It has been proposed that vitamin D affects a number of biological processes involved in the pathogenesis of hypertensive disorders of pregnancy. Therefore, a seasonal variation in the risk of these disorders might be expected in areas such as Denmark with marked seasonal variation in sunlight exposure. In this study, we aimed to evaluate the existence of this association. Material and methods: We used information from a cohort of 50 665 previously healthy, nulliparous women with singleton pregnancies. All women gave birth between 1989 and 2010 at Aarhus University Hospital, Denmark. Logistic regression analyses combined with the cubic spline method were used to estimate the seasonal variation for each outcome: gestational hypertension and preeclampsia, after adjusting for calendar time. Results: Of the 50 665 women included, 8.5% were diagnosed with a hypertensive disorder of pregnancy. The overall tendency was towards increasing risk when conceiving during spring and early summer, peaking midsummer, and subsequently decreasing steadily during late summer and fall to reach the nadir by winter. Seasonal variation was found for; gestational hypertension (P =.01); preeclampsia (P =.001) and early-onset preeclampsia (P =.014). Conclusions: We found a seasonal variation in the risk of the hypertensive disorders of pregnancy in a large cohort of Danish nulliparous women. The highest risk was seen in women with the estimated date of conception in June and August, that is, during summer. Seasonal variation in vitamin D status may explain this association.

KW - early-onset preeclampsia

KW - gestational hypertension

KW - hypertensive disorders of pregnancy

KW - preeclampsia

KW - seasons

KW - vitamin D

KW - VITAMIN-D

KW - PREECLAMPSIA

KW - PREVALENCE

U2 - 10.1111/aogs.13786

DO - 10.1111/aogs.13786

M3 - Journal article

C2 - 32020602

VL - 99

SP - 623

EP - 630

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

SN - 0001-6349

IS - 5

ER -