Scandinavian Multicenter Acute Subdural Hematoma (SMASH) Study: Study Protocol for a Multinational Population-Based Consecutive Cohort

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DOI

  • Jiri Bartek, Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.
  • ,
  • Christian Laugesen, Department of Neurosurgery, Copenhagen University Hospital, Rigshospitalet, 7 Inge Lehmanns Vej, 9.th Floor, Entrance 2, DK-2100 Copenhagen, Denmark.
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  • Sadia Mirza, Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.
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  • Axel Forsse, Department of Neurosurgery, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense, Denmark. torbenslottjensen@hotmail.com.
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  • Michael Anders Petersen, Department of Neurosurgery, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense, Denmark. torbenslottjensen@hotmail.com.
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  • Alba Corell, Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden.
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  • Philip Wilhelm Dyhrfort, Department of Neurosurgery, Uppsala University Hospital, Uppsala Sweden.
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  • Henrietta Nittby Redebrandt, Department of Neurosurgery, Lund University Hospital, Lund, Sweden.
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  • Linus Reen, Department of Neurosurgery, Lund University Hospital, Lund, Sweden.
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  • Shaian Zolfaghari, Department of Neurosurgery, Lund University Hospital, Lund, Sweden.
  • ,
  • Lovisa Tobieson, Department of Neurosurgery, Linköping University Hospital, Linköping, Sweden.
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  • Björn Carlsvärd, Department of Neurosurgery, Linköping University Hospital, Linköping, Sweden.
  • ,
  • Bo Bergholt
  • Asma Bashir
  • ,
  • Preben Soerensen
  • Arzu Bilgin, Department of Neurosurgery, Aalborg University Hospital, Aalborg, Denmark.
  • ,
  • Conny Johansson, Department of Neurosurgery, Umeå University Hospital, Umeå, Sweden.
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  • Peter Lindvall, Department of Neurosurgery, Umeå University Hospital, Umeå, Sweden.
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  • Petter Förander, Department of Neurosurgery, Uppsala University Hospital, Uppsala Sweden.
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  • Bo-Michael Bellander, Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.
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  • Jacob B Springborg, Department of Neurosurgery, Copenhagen University Hospital, Rigshospitalet, 7 Inge Lehmanns Vej, 9.th Floor, Entrance 2, DK-2100 Copenhagen, Denmark.
  • ,
  • Asgeir S Jakola, Department of Child and Adolescent Psychiatry, Queen Silvia's Children's Hospital, Sahlgrenska. University Hospital, Gothenburg, Sweden; Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Sweden.

BACKGROUND: Traumatic acute subdural hematomas (ASDHs) are associated with high rate of morbidity and mortality, especially in elderly individuals. However, recent reports indicate that the morbidity and mortality rates might have improved.

OBJECTIVE: To evaluate postoperative (30-d) mortality in younger vs elderly (≥70 yr) patients with ASDH. Comparing younger and elderly patients, the secondary objectives are morbidity patterns of care and 6 mo outcome according to Glasgow outcome scale (GOS). Finally, in patients with traumatic ASDH, we aim to provide prognostic variables.

METHODS: This is a large-scale population-based Scandinavian study including all neurosurgical departments in Denmark and Sweden. All adult (≥18 yr) patients surgically treated between 2010 and 2014 for a traumatic ASDH in Denmark and Sweden will be included. Identification at clinicaltrials.gov is NCT03284190.

EXPECTED OUTCOMES: We expect to provide data on potential differences between younger vs elderly patients in terms of mortality and morbidity. We hypothesize that elderly patients selected for surgery have a similar pattern of care as compared with younger patients. We will provide functional outcome in terms of GOS at 6 mo in younger vs elderly patients undergoing ASDH evacuation. Finally, clinical useful prognostic factors for favorable (GOS 4-5) vs unfavorable (GOS 1-3) will be identified.

DISCUSSION: An improved understanding of the clinical outcome, treatment and resource allocation, clinical course, and the prognostic factors of traumatic ASDH will allow neurosurgeons to make better treatment decisions.

OriginalsprogEngelsk
TidsskriftNeurosurgery
Vol/bind84
Nummer3
Sider (fra-til)799-803
Antal sider5
ISSN0148-396X
DOI
StatusUdgivet - mar. 2019

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