Safety evaluation of α‐lipoic acid supplementation: A systematic review and meta‐analysis of randomized placebo‐controlled clinical studies

Federica Fogacci, Manfredi Rizzo, Christoffer Krogager, Cormac Kennedy, Coralie M.G. Georges, Tamara Knežević, Evangelos Liberopoulos, Alexandre Vallée, Pablo Pérez‐martínez, Eliane F.E. Wenstedt, Agnė Šatrauskienė, Michal Vrablík, Arrigo F.G. Cicero*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

46 Citationer (Scopus)

Abstract

Alpha‐lipoic acid (ALA) is a natural short‐chain fatty acid that has attracted great attention in recent years as an antioxidant molecule. However, some concerns have been recently raised regarding its safety profile. To address the issue, we aimed to assess ALA safety profile through a systematic review of the literature and a meta‐analysis of the available randomized placebo‐controlled clinical studies. The literature search included EMBASE, PubMed Medline, SCOPUS, Google Scholar, and ISI Web of Science by Clarivate databases up to 15th August 2020. Data were pooled from 71 clinical studies, comprising 155 treatment arms, which included 4749 subjects with 2558 subjects treated with ALA and 2294 assigned to placebo. A meta‐analysis of extracted data suggested that supplementation with ALA was not associated with an increased risk of any treatment‐emergent adverse event (all p > 0.05). ALA supplementation was safe, even in subsets of studies categorized according to smoking habit, cardiovascular disease, presence of diabetes, pregnancy status, neurological disorders, rheumatic affections, severe renal impairment, and status of children/adolescents at baseline.

OriginalsprogEngelsk
Artikelnummer1011
TidsskriftAntioxidants
Vol/bind9
Nummer10
Antal sider33
ISSN2076-3921
DOI
StatusUdgivet - okt. 2020

Fingeraftryk

Dyk ned i forskningsemnerne om 'Safety evaluation of α‐lipoic acid supplementation: A systematic review and meta‐analysis of randomized placebo‐controlled clinical studies'. Sammen danner de et unikt fingeraftryk.

Citationsformater