Runs of homozygosity and distribution of functional variants in cattle genome

Publikation: KonferencebidragPaperForskningpeer review

Standard

Runs of homozygosity and distribution of functional variants in cattle genome. / Zhang, Qianqian; Guldbrandtsen, Bernt; Bosse, Mirte; Lund, Mogens Sandø; Sahana, Goutam.

2014. Paper præsenteret ved 10th World Congress on Genetics Applied to Livestock Production (WCGALP), Vancouver, Canada.

Publikation: KonferencebidragPaperForskningpeer review

Harvard

Zhang, Q, Guldbrandtsen, B, Bosse, M, Lund, MS & Sahana, G 2014, 'Runs of homozygosity and distribution of functional variants in cattle genome', Paper fremlagt ved 10th World Congress on Genetics Applied to Livestock Production (WCGALP), Vancouver, Canada, 17/08/2014 - 22/08/2014. <https://event.crowdcompass.com/wcgalp2014#/activity/67ND0x1HWf>

APA

Zhang, Q., Guldbrandtsen, B., Bosse, M., Lund, M. S., & Sahana, G. (2014). Runs of homozygosity and distribution of functional variants in cattle genome. Paper præsenteret ved 10th World Congress on Genetics Applied to Livestock Production (WCGALP), Vancouver, Canada. https://event.crowdcompass.com/wcgalp2014#/activity/67ND0x1HWf

CBE

Zhang Q, Guldbrandtsen B, Bosse M, Lund MS, Sahana G. 2014. Runs of homozygosity and distribution of functional variants in cattle genome. Paper præsenteret ved 10th World Congress on Genetics Applied to Livestock Production (WCGALP), Vancouver, Canada.

MLA

Zhang, Qianqian o.a.. Runs of homozygosity and distribution of functional variants in cattle genome. 10th World Congress on Genetics Applied to Livestock Production (WCGALP), 17 aug. 2014, Vancouver, Canada, Paper, 2014. 3 s.

Vancouver

Zhang Q, Guldbrandtsen B, Bosse M, Lund MS, Sahana G. Runs of homozygosity and distribution of functional variants in cattle genome. 2014. Paper præsenteret ved 10th World Congress on Genetics Applied to Livestock Production (WCGALP), Vancouver, Canada.

Author

Zhang, Qianqian ; Guldbrandtsen, Bernt ; Bosse, Mirte ; Lund, Mogens Sandø ; Sahana, Goutam. / Runs of homozygosity and distribution of functional variants in cattle genome. Paper præsenteret ved 10th World Congress on Genetics Applied to Livestock Production (WCGALP), Vancouver, Canada.3 s.

Bibtex

@conference{be5acdaf0d0d40b2896ce332ab581612,
title = "Runs of homozygosity and distribution of functional variants in cattle genome",
abstract = "Runs of homozygosity (ROH) are identified in four dairy cattle breeds using NGS data. Cattle populations have been exposed to strong artificial selection for some generations. Genomic regions under selection will show increased levels of ROH. By investigating the relationship between ROH and distribution of predicted deleterious and tolerated variants, we can gain insight into how selection shapes the distribution of functional variants in inbred regions. We observe that predicted deleterious variants are more enriched in ROHs than predicted tolerated variants. Moreover, increase of enrichment of deleterious variants is significantly more pronounced in short and medium ROH regions than long ROH regions (p<0.001). This study demonstrates that artificial selection strongly shapes the distribution of functional variants in ROH regions in cattle populations and contributes in understanding the effects of inbreeding on shaping the distribution of functional variants in cattle genome",
author = "Qianqian Zhang and Bernt Guldbrandtsen and Mirte Bosse and Lund, {Mogens Sand{\o}} and Goutam Sahana",
year = "2014",
month = aug,
day = "17",
language = "English",
note = "10th World Congress on Genetics Applied to Livestock Production (WCGALP), WCGALP ; Conference date: 17-08-2014 Through 22-08-2014",

}

RIS

TY - CONF

T1 - Runs of homozygosity and distribution of functional variants in cattle genome

AU - Zhang, Qianqian

AU - Guldbrandtsen, Bernt

AU - Bosse, Mirte

AU - Lund, Mogens Sandø

AU - Sahana, Goutam

N1 - Conference code: 10th

PY - 2014/8/17

Y1 - 2014/8/17

N2 - Runs of homozygosity (ROH) are identified in four dairy cattle breeds using NGS data. Cattle populations have been exposed to strong artificial selection for some generations. Genomic regions under selection will show increased levels of ROH. By investigating the relationship between ROH and distribution of predicted deleterious and tolerated variants, we can gain insight into how selection shapes the distribution of functional variants in inbred regions. We observe that predicted deleterious variants are more enriched in ROHs than predicted tolerated variants. Moreover, increase of enrichment of deleterious variants is significantly more pronounced in short and medium ROH regions than long ROH regions (p<0.001). This study demonstrates that artificial selection strongly shapes the distribution of functional variants in ROH regions in cattle populations and contributes in understanding the effects of inbreeding on shaping the distribution of functional variants in cattle genome

AB - Runs of homozygosity (ROH) are identified in four dairy cattle breeds using NGS data. Cattle populations have been exposed to strong artificial selection for some generations. Genomic regions under selection will show increased levels of ROH. By investigating the relationship between ROH and distribution of predicted deleterious and tolerated variants, we can gain insight into how selection shapes the distribution of functional variants in inbred regions. We observe that predicted deleterious variants are more enriched in ROHs than predicted tolerated variants. Moreover, increase of enrichment of deleterious variants is significantly more pronounced in short and medium ROH regions than long ROH regions (p<0.001). This study demonstrates that artificial selection strongly shapes the distribution of functional variants in ROH regions in cattle populations and contributes in understanding the effects of inbreeding on shaping the distribution of functional variants in cattle genome

M3 - Paper

T2 - 10th World Congress on Genetics Applied to Livestock Production (WCGALP)

Y2 - 17 August 2014 through 22 August 2014

ER -