Role of Infection, Autoimmunity, Atopic Disorders, and the Immune System in Schizophrenia: Evidence from Epidemiological and Genetic Studies

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Role of Infection, Autoimmunity, Atopic Disorders, and the Immune System in Schizophrenia : Evidence from Epidemiological and Genetic Studies. / Benros, Michael E.; Mortensen, Preben B.

Neuroinflammation and Schizophrenia. Springer, 2020. s. 141-159 (Current Topics in Behavioral Neurosciences, Bind 44).

Publikation: Bidrag til bog/antologi/rapport/proceedingBidrag til bog/antologiForskningpeer review

Harvard

Benros, ME & Mortensen, PB 2020, Role of Infection, Autoimmunity, Atopic Disorders, and the Immune System in Schizophrenia: Evidence from Epidemiological and Genetic Studies. i Neuroinflammation and Schizophrenia. Springer, Current Topics in Behavioral Neurosciences, bind 44, s. 141-159. https://doi.org/10.1007/7854_2019_93

APA

Benros, M. E., & Mortensen, P. B. (2020). Role of Infection, Autoimmunity, Atopic Disorders, and the Immune System in Schizophrenia: Evidence from Epidemiological and Genetic Studies. I Neuroinflammation and Schizophrenia (s. 141-159). Springer. Current Topics in Behavioral Neurosciences, Bind. 44 https://doi.org/10.1007/7854_2019_93

CBE

Benros ME, Mortensen PB. 2020. Role of Infection, Autoimmunity, Atopic Disorders, and the Immune System in Schizophrenia: Evidence from Epidemiological and Genetic Studies. I Neuroinflammation and Schizophrenia. Springer. s. 141-159. (Current Topics in Behavioral Neurosciences, Bind 44). https://doi.org/10.1007/7854_2019_93

MLA

Benros, Michael E. og Preben B. Mortensen "Role of Infection, Autoimmunity, Atopic Disorders, and the Immune System in Schizophrenia: Evidence from Epidemiological and Genetic Studies". Neuroinflammation and Schizophrenia. Springer. (Current Topics in Behavioral Neurosciences, Bind 44). 2020, 141-159. https://doi.org/10.1007/7854_2019_93

Vancouver

Benros ME, Mortensen PB. Role of Infection, Autoimmunity, Atopic Disorders, and the Immune System in Schizophrenia: Evidence from Epidemiological and Genetic Studies. I Neuroinflammation and Schizophrenia. Springer. 2020. s. 141-159. (Current Topics in Behavioral Neurosciences, Bind 44). https://doi.org/10.1007/7854_2019_93

Author

Benros, Michael E. ; Mortensen, Preben B. / Role of Infection, Autoimmunity, Atopic Disorders, and the Immune System in Schizophrenia : Evidence from Epidemiological and Genetic Studies. Neuroinflammation and Schizophrenia. Springer, 2020. s. 141-159 (Current Topics in Behavioral Neurosciences, Bind 44).

Bibtex

@inbook{9d47f2834325444484b6bc028040d17b,
title = "Role of Infection, Autoimmunity, Atopic Disorders, and the Immune System in Schizophrenia: Evidence from Epidemiological and Genetic Studies",
abstract = "An immunologic component to schizophrenia has been increasingly recognized, where infections and chronic inflammatory diseases as atopic disorders and autoimmune diseases could be involved in the pathogenesis of schizophrenia. Psychotic symptoms can be directly triggered by infections reaching the CNS, or be secondary to systemic inflammation indirectly affecting the brain through immune components, such as brain-reactive antibodies and cytokines. Large-scale epidemiological studies have consistently displayed that infections, autoimmune diseases, and atopic disorders are associated with increased risk of schizophrenia and that schizophrenia is associated with increased levels of immune markers at diagnosis. However, since there is also an increased risk of immune-related diseases after the diagnosis with schizophrenia and in family members of individuals with schizophrenia, parts of the association could also be due to heritable factors. Shared genetic factor might account for some of this increased prevalence of immune-related diseases among individuals with schizophrenia, and indeed the most pronounced genetic association with schizophrenia lies within the HLA region, which is one of the most important regions for the immune system. However, genetic studies have shown that the common genetic variants associated with schizophrenia do not seem to increase the susceptibility for acquiring infections. Nonetheless, shared genes with the susceptibility for acquiring infections not captured by the polygenic risk score for schizophrenia could still influence the association.",
keywords = "Autoimmune diseases, Epidemiology, Genetics, Immunology, Infection, Inflammation, Register-based, Schizophrenia",
author = "Benros, {Michael E.} and Mortensen, {Preben B.}",
year = "2020",
doi = "10.1007/7854_2019_93",
language = "English",
isbn = "978-3-030-39140-9",
series = "Current Topics in Behavioral Neurosciences",
publisher = "Springer",
pages = "141--159",
booktitle = "Neuroinflammation and Schizophrenia",

}

RIS

TY - CHAP

T1 - Role of Infection, Autoimmunity, Atopic Disorders, and the Immune System in Schizophrenia

T2 - Evidence from Epidemiological and Genetic Studies

AU - Benros, Michael E.

AU - Mortensen, Preben B.

PY - 2020

Y1 - 2020

N2 - An immunologic component to schizophrenia has been increasingly recognized, where infections and chronic inflammatory diseases as atopic disorders and autoimmune diseases could be involved in the pathogenesis of schizophrenia. Psychotic symptoms can be directly triggered by infections reaching the CNS, or be secondary to systemic inflammation indirectly affecting the brain through immune components, such as brain-reactive antibodies and cytokines. Large-scale epidemiological studies have consistently displayed that infections, autoimmune diseases, and atopic disorders are associated with increased risk of schizophrenia and that schizophrenia is associated with increased levels of immune markers at diagnosis. However, since there is also an increased risk of immune-related diseases after the diagnosis with schizophrenia and in family members of individuals with schizophrenia, parts of the association could also be due to heritable factors. Shared genetic factor might account for some of this increased prevalence of immune-related diseases among individuals with schizophrenia, and indeed the most pronounced genetic association with schizophrenia lies within the HLA region, which is one of the most important regions for the immune system. However, genetic studies have shown that the common genetic variants associated with schizophrenia do not seem to increase the susceptibility for acquiring infections. Nonetheless, shared genes with the susceptibility for acquiring infections not captured by the polygenic risk score for schizophrenia could still influence the association.

AB - An immunologic component to schizophrenia has been increasingly recognized, where infections and chronic inflammatory diseases as atopic disorders and autoimmune diseases could be involved in the pathogenesis of schizophrenia. Psychotic symptoms can be directly triggered by infections reaching the CNS, or be secondary to systemic inflammation indirectly affecting the brain through immune components, such as brain-reactive antibodies and cytokines. Large-scale epidemiological studies have consistently displayed that infections, autoimmune diseases, and atopic disorders are associated with increased risk of schizophrenia and that schizophrenia is associated with increased levels of immune markers at diagnosis. However, since there is also an increased risk of immune-related diseases after the diagnosis with schizophrenia and in family members of individuals with schizophrenia, parts of the association could also be due to heritable factors. Shared genetic factor might account for some of this increased prevalence of immune-related diseases among individuals with schizophrenia, and indeed the most pronounced genetic association with schizophrenia lies within the HLA region, which is one of the most important regions for the immune system. However, genetic studies have shown that the common genetic variants associated with schizophrenia do not seem to increase the susceptibility for acquiring infections. Nonetheless, shared genes with the susceptibility for acquiring infections not captured by the polygenic risk score for schizophrenia could still influence the association.

KW - Autoimmune diseases

KW - Epidemiology

KW - Genetics

KW - Immunology

KW - Infection

KW - Inflammation

KW - Register-based

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=85078552251&partnerID=8YFLogxK

U2 - 10.1007/7854_2019_93

DO - 10.1007/7854_2019_93

M3 - Book chapter

C2 - 30895532

AN - SCOPUS:85078552251

SN - 978-3-030-39140-9

T3 - Current Topics in Behavioral Neurosciences

SP - 141

EP - 159

BT - Neuroinflammation and Schizophrenia

PB - Springer

ER -