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Role of Apoptosis in Wound Healing and Apoptosis Alterations in Microgravity

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

DOI

  • Stefan Riwaldt, Department of Microgravity and Translational Regenerative Medicine, Otto von Guericke University, Pfälzer Platz, 39106 Magdeburg, Germany., 2 Clinic for Plastic, Aesthetic and Hand Surgery, Otto-von-Guericke University , Magdeburg, Germany ., Clinic and Policlinic for Plastic, Aesthetic and Hand Surgery , Otto-von-Guericke-University , 39120 Magdeburg , Germany, Otto von Guericke Univ, Otto von Guericke University, Dept Gastroenterol Hepatol & Infect Dis, Department of Dermatology, University Hospital Magdeburg, University of Magdeburg, 39120 Magdeburg, Germany.
  • ,
  • Thomas J Corydon
  • Desiré Pantalone, University of Florence, Florence
  • ,
  • Jayashree Sahana
  • Petra Wise, University of Southern California / Norris Cancer Center, University of Southern California, Los Angeles
  • ,
  • Markus Wehland
  • Marcus Krüger, Otto von Guericke Univ, Otto von Guericke University, Dept Gastroenterol Hepatol & Infect Dis
  • ,
  • Daniela Melnik, Department of Microgravity and Translational Regenerative Medicine, Otto von Guericke University, Pfälzer Platz, 39106 Magdeburg, Germany., 2 Clinic for Plastic, Aesthetic and Hand Surgery, Otto-von-Guericke University , Magdeburg, Germany ., Clinic and Policlinic for Plastic, Aesthetic and Hand Surgery , Otto-von-Guericke-University , 39120 Magdeburg , Germany, Otto von Guericke Univ, Otto von Guericke University, Dept Gastroenterol Hepatol & Infect Dis, Department of Dermatology, University Hospital Magdeburg, University of Magdeburg, 39120 Magdeburg, Germany.
  • ,
  • Sascha Kopp, Department of Microgravity and Translational Regenerative Medicine, Otto von Guericke University, Pfälzer Platz, 39106 Magdeburg, Germany., 2 Clinic for Plastic, Aesthetic and Hand Surgery, Otto-von-Guericke University , Magdeburg, Germany ., Clinic and Policlinic for Plastic, Aesthetic and Hand Surgery , Otto-von-Guericke-University , 39120 Magdeburg , Germany, Otto von Guericke Univ, Otto von Guericke University, Dept Gastroenterol Hepatol & Infect Dis, Department of Dermatology, University Hospital Magdeburg, University of Magdeburg, 39120 Magdeburg, Germany., Research Group “Magdeburger Arbeitsgemeinschaft für Forschung unter Raumfahrt‐ und Schwerelosigkeitsbedingungen” (MARS)
  • ,
  • Manfred Infanger, Otto von Guericke Univ, Otto von Guericke University, Dept Gastroenterol Hepatol & Infect Dis
  • ,
  • Daniela Grimm

Functioning as the outermost self-renewing protective layer of the human organism, skin protects against a multitude of harmful biological and physical stimuli. Consisting of ectodermal, mesenchymal, and neural crest-derived cell lineages, tissue homeostasis, and signal transduction are finely tuned through the interplay of various pathways. A health problem of astronauts in space is skin deterioration. Until today, wound healing has not been considered as a severe health concern for crew members. This can change with deep space exploration missions and commercial spaceflights together with space tourism. Albeit the molecular process of wound healing is not fully elucidated yet, there have been established significant conceptual gains and new scientific methods. Apoptosis, e.g., programmed cell death, enables orchestrated development and cell removal in wounded or infected tissue. Experimental designs utilizing microgravity allow new insights into the role of apoptosis in wound healing. Furthermore, impaired wound healing in unloading conditions would depict a significant challenge in human-crewed exploration space missions. In this review, we provide an overview of alterations in the behavior of cutaneous cell lineages under microgravity in regard to the impact of apoptosis in wound healing. We discuss the current knowledge about wound healing in space and simulated microgravity with respect to apoptosis and available therapeutic strategies.

OriginalsprogEngelsk
TidsskriftFrontiers in Bioengineering and Biotechnology
Vol/bind9
Sider (fra-til)679650
ISSN2296-4185
DOI
StatusUdgivet - 2021

Bibliografisk note

Copyright © 2021 Riwaldt, Corydon, Pantalone, Sahana, Wise, Wehland, Krüger, Melnik, Kopp, Infanger and Grimm.

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