Roadmap for a precision-medicine initiative in the Nordic region

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisKommentar/debatForskningpeer review

DOI

  • Pål Rasmus Njølstad, Medical and Population Genetics Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA. pal.njolstad@uib.no.
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  • Ole Andreas Andreassen, Department of Cardiology, Oslo University Hospital, Ullevål, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
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  • Søren Brunak, Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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  • Anders D Børglum
  • Joakim Dillner, Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden and Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
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  • Tõnu Esko, Rheumatology Program, Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
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  • Paul W Franks, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.
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  • Nelson Freimer, UCLA Center for Neurobehavioral Genetics, Charles E. Young Drive South, Los Angeles, California 90024, USA.
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  • Leif Groop, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00251, Finland.
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  • Hakon Heimer, School of Pharmaceutical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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  • David M Hougaard, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark.
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  • Eivind Hovig, Department of Gynaecologic Oncology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway. Institute for Cancer Genetics and Informatics, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway. Faculty of Medicine, University of Oslo, Oslo, Norway.
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  • Kristian Hveem, Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.
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  • Anu Jalanko, Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki, Finland.
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  • Jaakko Kaprio, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00251, Finland.
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  • Gun Peggy Knudsen, Norwegian Institute of Public Health, Oslo, Norway.
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  • Mads Melbye, Københavns Universitet
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  • Andres Metspalu, 1] Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia. [2] Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA. [3] Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140 Cambridge, Massachusetts 02142, USA. [4] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
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  • Preben Bo Mortensen
  • Juni Palmgren, Swedish e-Science Research Center, SeRC, Stockholm, Sweden.
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  • Aarno Palotie, Department of Neurosurgery, Neuro-oncology Research Group, Cancer Center Amsterdam, VU University Medical Center, 1007 MB Amsterdam, the Netherlands; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
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  • Wenche Reed, Department of Research, Innovation and Education, Oslo University Hospital, Oslo, Norway.
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  • Hreinn Stefánsson, The Icelandic Cancer Registry, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
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  • Nathan O Stitziel, McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, Missouri 63108, USA.
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  • Patrick F Sullivan, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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  • Unnur Thorsteinsdóttir, Department of Genetics, Washington University, Saint Louis, MO, USA.
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  • Marc Vaudel, Department of Clinical Science, KG Jebsen Center for Diabetes Research, University of Bergen, Bergen, Norway.
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  • Eero Vuorio, Department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland.
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  • Thomas Werge, Department of Clinical Microbiology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; Institute for Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
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  • Camilla Stoltenberg, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway Norwegian Institute of Public Health, Oslo, Norway.
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  • Kári Stefánsson, The Icelandic Cancer Registry, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

The Nordic region, comprising primarily Denmark, Estonia, Finland, Iceland, Norway and Sweden, has many of the necessary characteristics for being at the forefront of genome-based precision medicine. These include egalitarian and universal healthcare, expertly curated patient and population registries, biobanks, large population-based prospective cohorts linked to registries and biobanks, and a widely embraced sense of social responsibility that motivates public engagement in biomedical research. However, genome-based precision medicine can be achieved only through coordinated action involving all actors in the healthcare sector. Now is an opportune time to organize scientists in the Nordic region, together with other stakeholders including patient representatives, governments, pharmaceutical companies, academic institutions and funding agencies, to initiate a Nordic Precision Medicine Initiative. We present a roadmap for how this organization can be created. The Initiative should facilitate research, clinical trials and knowledge transfer to meet regional and global health challenges.

OriginalsprogEngelsk
TidsskriftNature Genetics
Vol/bind51
Nummer6
Sider (fra-til)924-930
Antal sider7
ISSN1061-4036
DOI
StatusUdgivet - jun. 2019

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