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RNA-induced inflammation and migration of precursor neurons initiates neuronal circuit regeneration in zebrafish

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  • Celia Vandestadt, Monash University
  • ,
  • Gilles C. Vanwalleghem
  • Mitra Amiri Khabooshan, Monash University
  • ,
  • Alon M. Douek, Monash University
  • ,
  • Hozana Andrade Castillo, Monash University, Centro Nacional de Pesquisa em Energia e Materiais
  • ,
  • Mei Li, Monash University
  • ,
  • Keith Schulze, Monash University
  • ,
  • Emily Don, Macquarie University
  • ,
  • Sebastian Alexander Stamatis, Monash University
  • ,
  • Madara Ratnadiwakara, Hudson Institute of Medical Research
  • ,
  • Minna Liisa Änkö, Hudson Institute of Medical Research, Monash University
  • ,
  • Ethan K. Scott, University of Queensland
  • ,
  • Jan Kaslin, Monash University

Tissue regeneration and functional restoration after injury are considered as stem- and progenitor-cell-driven processes. In the central nervous system, stem cell-driven repair is slow and problematic because function needs to be restored rapidly for vital tasks. In highly regenerative vertebrates, such as zebrafish, functional recovery is rapid, suggesting a capability for fast cell production and functional integration. Surprisingly, we found that migration of dormant “precursor neurons” to the injury site pioneers functional circuit regeneration after spinal cord injury and controls the subsequent stem-cell-driven repair response. Thus, the precursor neurons make do before the stem cells make new. Furthermore, RNA released from the dying or damaged cells at the site of injury acts as a signal to attract precursor neurons for repair. Taken together, our data demonstrate an unanticipated role of neuronal migration and RNA as drivers of neural repair.

TidsskriftDevelopmental Cell
Sider (fra-til)2364-2380.e8
StatusUdgivet - aug. 2021
Eksternt udgivetJa

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© 2021 Elsevier Inc.

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