Risk of Helicobacter pylori transmission by faecal microbiota transplantation via oral capsules

Anne Karmisholt Grosen; Susan Mikkelsen; Simon Mark Dahl Baunwall; Jens Frederik Dahlerup; Lise Tornvig Erikstrup; Christian Lodberg Hvas; Christian Erikstrup

doi:10.1016/j.cmi.2023.02.011

Risk of Helicobacter pylori transmission by faecal microbiota transplantation via oral capsules

Anne Karmisholt Grosen^*, Susan Mikkelsen, Simon Mark Dahl Baunwall, Jens Frederik Dahlerup, Lise Tornvig Erikstrup, Christian Lodberg Hvas, Christian Erikstrup

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

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Abstract

Objectives: The aim was to determine if Helicobacter pylori is transmitted from donors to recipients by faecal microbiota transplantation (FMT) via oral capsules. Methods: In a cohort of faeces donors not primarily screened for H. pylori, consecutive stool samples were retrospectively analysed by the H. pylori stool antigen test (SAT). Subsequently, we analysed recipient stool samples collected before and after receiving faeces donated by H. pylori SAT–positive donors, and we recorded recipient use of antibiotics and proton pump inhibitors. All stool samples were frozen upon collection and stored at −80°C until use. Results: Thirteen out of 40 faeces donors (33%; 95% CI, 20–48%) were H. pylori SAT–positive. Among those positive, five donors donated faeces for 28 capsule-based FMTs performed in 26 recipients with stool samples collected before and after FMT. At a median of 59 days (range, 7–84 days) after FMT, no recipients (0%; 95% CI, 0–11%) were H. pylori SAT–positive. Discussion: We found no occurrence of H. pylori transmission from healthy, asymptomatic donors to recipients by oral capsule–based FMT, although with a wide CI.

Originalsprog	Engelsk
Tidsskrift	Clinical Microbiology and Infection
Vol/bind	29
Nummer	6
Sider (fra-til)	799.e1-799.e4
Antal sider	4
ISSN	1198-743X
DOI	https://doi.org/10.1016/j.cmi.2023.02.011
Status	Udgivet - jun. 2023

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10.1016/j.cmi.2023.02.011Licens: CC BY

1-s2.0-S1198743X23000812-mainForlagets udgivne version, 216 KBLicens: CC BY

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title = "Risk of Helicobacter pylori transmission by faecal microbiota transplantation via oral capsules",

abstract = "Objectives: The aim was to determine if Helicobacter pylori is transmitted from donors to recipients by faecal microbiota transplantation (FMT) via oral capsules. Methods: In a cohort of faeces donors not primarily screened for H. pylori, consecutive stool samples were retrospectively analysed by the H. pylori stool antigen test (SAT). Subsequently, we analysed recipient stool samples collected before and after receiving faeces donated by H. pylori SAT–positive donors, and we recorded recipient use of antibiotics and proton pump inhibitors. All stool samples were frozen upon collection and stored at −80°C until use. Results: Thirteen out of 40 faeces donors (33%; 95% CI, 20–48%) were H. pylori SAT–positive. Among those positive, five donors donated faeces for 28 capsule-based FMTs performed in 26 recipients with stool samples collected before and after FMT. At a median of 59 days (range, 7–84 days) after FMT, no recipients (0%; 95% CI, 0–11%) were H. pylori SAT–positive. Discussion: We found no occurrence of H. pylori transmission from healthy, asymptomatic donors to recipients by oral capsule–based FMT, although with a wide CI.",

keywords = "Donor screening, Faecal microbiota transplantation, FMT, Helicobacter pylori, Transmission, Feces/microbiology, Humans, Retrospective Studies, Tissue Donors, Fecal Microbiota Transplantation",

author = "Grosen, {Anne Karmisholt} and Susan Mikkelsen and Baunwall, {Simon Mark Dahl} and Dahlerup, {Jens Frederik} and Erikstrup, {Lise Tornvig} and Hvas, {Christian Lodberg} and Christian Erikstrup",

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Risk of Helicobacter pylori transmission by faecal microbiota transplantation via oral capsules. / Grosen, Anne Karmisholt ; Mikkelsen, Susan ; Baunwall, Simon Mark Dahl et al.
I: Clinical Microbiology and Infection, Bind 29, Nr. 6, 06.2023, s. 799.e1-799.e4.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Risk of Helicobacter pylori transmission by faecal microbiota transplantation via oral capsules

AU - Grosen, Anne Karmisholt

AU - Mikkelsen, Susan

AU - Baunwall, Simon Mark Dahl

AU - Dahlerup, Jens Frederik

AU - Erikstrup, Lise Tornvig

AU - Hvas, Christian Lodberg

AU - Erikstrup, Christian

PY - 2023/6

Y1 - 2023/6

N2 - Objectives: The aim was to determine if Helicobacter pylori is transmitted from donors to recipients by faecal microbiota transplantation (FMT) via oral capsules. Methods: In a cohort of faeces donors not primarily screened for H. pylori, consecutive stool samples were retrospectively analysed by the H. pylori stool antigen test (SAT). Subsequently, we analysed recipient stool samples collected before and after receiving faeces donated by H. pylori SAT–positive donors, and we recorded recipient use of antibiotics and proton pump inhibitors. All stool samples were frozen upon collection and stored at −80°C until use. Results: Thirteen out of 40 faeces donors (33%; 95% CI, 20–48%) were H. pylori SAT–positive. Among those positive, five donors donated faeces for 28 capsule-based FMTs performed in 26 recipients with stool samples collected before and after FMT. At a median of 59 days (range, 7–84 days) after FMT, no recipients (0%; 95% CI, 0–11%) were H. pylori SAT–positive. Discussion: We found no occurrence of H. pylori transmission from healthy, asymptomatic donors to recipients by oral capsule–based FMT, although with a wide CI.

AB - Objectives: The aim was to determine if Helicobacter pylori is transmitted from donors to recipients by faecal microbiota transplantation (FMT) via oral capsules. Methods: In a cohort of faeces donors not primarily screened for H. pylori, consecutive stool samples were retrospectively analysed by the H. pylori stool antigen test (SAT). Subsequently, we analysed recipient stool samples collected before and after receiving faeces donated by H. pylori SAT–positive donors, and we recorded recipient use of antibiotics and proton pump inhibitors. All stool samples were frozen upon collection and stored at −80°C until use. Results: Thirteen out of 40 faeces donors (33%; 95% CI, 20–48%) were H. pylori SAT–positive. Among those positive, five donors donated faeces for 28 capsule-based FMTs performed in 26 recipients with stool samples collected before and after FMT. At a median of 59 days (range, 7–84 days) after FMT, no recipients (0%; 95% CI, 0–11%) were H. pylori SAT–positive. Discussion: We found no occurrence of H. pylori transmission from healthy, asymptomatic donors to recipients by oral capsule–based FMT, although with a wide CI.

KW - Donor screening

KW - Faecal microbiota transplantation

KW - FMT

KW - Helicobacter pylori

KW - Transmission

KW - Feces/microbiology

KW - Humans

KW - Retrospective Studies

KW - Tissue Donors

KW - Fecal Microbiota Transplantation

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U2 - 10.1016/j.cmi.2023.02.011

DO - 10.1016/j.cmi.2023.02.011

M3 - Journal article

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SN - 1198-743X

VL - 29

SP - 799.e1-799.e4

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 6

ER -

Risk of Helicobacter pylori transmission by faecal microbiota transplantation via oral capsules

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