Risk of Depression in People With Human Immunodeficiency Virus: A nationwide population-based matched cohort study

Cecilie V Vollmond; Malte M Tetens; Fie W Paulsen; Jan Gerstoft; Gitte Kronborg; Isik S Johansen; Carsten S Larsen; Lothar Wiese; Michael Dalager-Pedersen; Steffen Leth; Preben Bo Mortensen; Anne-Mette Lebech; Niels Obel; Lars H Omland

doi:10.1093/cid/ciad415

Risk of Depression in People With Human Immunodeficiency Virus: A nationwide population-based matched cohort study

Cecilie V Vollmond^*, Malte M Tetens, Fie W Paulsen, Jan Gerstoft, Gitte Kronborg, Isik S Johansen, Carsten S Larsen, Lothar Wiese, Michael Dalager-Pedersen, Steffen Leth, Preben Bo Mortensen, Anne-Mette Lebech, Niels Obel, Lars H Omland^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

1 Citationer (Scopus)

Abstract

BACKGROUND: HIV infection is associated with depression, but previous studies are imprecise and have not addressed familial factors.

METHODS: Nationwide, population-based matched cohort study of people with HIV (PWH) in Denmark between 1995 and 2021, matched on sex and date of birth with a comparison cohort randomly selected from the Danish population. Aditionally, family related factors were examined by inclusion of siblings of these cohorts. We calculated hazard ratios (HR) for depression, receipt of antidepressants, electroconvulsive therapy (ECT), and suicide and yearly proportions of study cohorts with psychiatric hospital contact due to depression and receipt of antidepressants from 10 years before to 10 years after study inclusion.

RESULTS: We included 5,943 PWH and 59,430 comparison cohort members. Median age was 38 years and 25% were women. We observed an increased risk of depression, receipt of antidepressants, ECT, and suicide among PWH in the 2 first years of observation (HR of 3.3 (95% CI: 2.5-4.4), 3.0 (95% CI: 2.7-3.4), 2.8 (95% CI: 0.9-8.6) and 10.7 (95% CI: 5.2-22.2)), thereafter the risk subsided, but remained increased. The proportions of PWH with psychiatric hospital contact due to depression and receipt of antidepressants were increased prior to-, and especially after HIV diagnosis. Risk of all outcomes were substantially lower among siblings of PWH than among PWH (HR for receipt of antidepressants was 1.1 (95% CI: 1.0-1.2)).

CONCLUSION: PWH have an increased risk of depression, especially in the first 2 years after HIV diagnosis. Family related factors are unlikely to explain this risk.

Originalsprog	Engelsk
Tidsskrift	Clinical Infectious Diseases
Vol/bind	77
Nummer	11
Sider (fra-til)	1569-1577
Antal sider	9
ISSN	1058-4838
DOI	https://doi.org/10.1093/cid/ciad415
Status	Udgivet - dec. 2023

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Vollmond, C. V., Tetens, M. M., Paulsen, F. W., Gerstoft, J., Kronborg, G., Johansen, I. S., Larsen, C. S., Wiese, L., Dalager-Pedersen, M., Leth, S., Mortensen, P. B., Lebech, A.-M., Obel, N., & Omland, L. H. (2023). Risk of Depression in People With Human Immunodeficiency Virus: A nationwide population-based matched cohort study. Clinical Infectious Diseases, 77(11), 1569-1577. https://doi.org/10.1093/cid/ciad415

@article{2db3b646525a46299d9423b38807ad53,

title = "Risk of Depression in People With Human Immunodeficiency Virus: A nationwide population-based matched cohort study",

abstract = "BACKGROUND: HIV infection is associated with depression, but previous studies are imprecise and have not addressed familial factors.METHODS: Nationwide, population-based matched cohort study of people with HIV (PWH) in Denmark between 1995 and 2021, matched on sex and date of birth with a comparison cohort randomly selected from the Danish population. Aditionally, family related factors were examined by inclusion of siblings of these cohorts. We calculated hazard ratios (HR) for depression, receipt of antidepressants, electroconvulsive therapy (ECT), and suicide and yearly proportions of study cohorts with psychiatric hospital contact due to depression and receipt of antidepressants from 10 years before to 10 years after study inclusion.RESULTS: We included 5,943 PWH and 59,430 comparison cohort members. Median age was 38 years and 25% were women. We observed an increased risk of depression, receipt of antidepressants, ECT, and suicide among PWH in the 2 first years of observation (HR of 3.3 (95% CI: 2.5-4.4), 3.0 (95% CI: 2.7-3.4), 2.8 (95% CI: 0.9-8.6) and 10.7 (95% CI: 5.2-22.2)), thereafter the risk subsided, but remained increased. The proportions of PWH with psychiatric hospital contact due to depression and receipt of antidepressants were increased prior to-, and especially after HIV diagnosis. Risk of all outcomes were substantially lower among siblings of PWH than among PWH (HR for receipt of antidepressants was 1.1 (95% CI: 1.0-1.2)).CONCLUSION: PWH have an increased risk of depression, especially in the first 2 years after HIV diagnosis. Family related factors are unlikely to explain this risk.",

keywords = "PWH, antidepressants, depression, Humans, Risk Factors, Male, Depression/epidemiology, HIV, HIV Infections/complications, Adult, Antidepressive Agents/therapeutic use, Female, Cohort Studies",

author = "Vollmond, {Cecilie V} and Tetens, {Malte M} and Paulsen, {Fie W} and Jan Gerstoft and Gitte Kronborg and Johansen, {Isik S} and Larsen, {Carsten S} and Lothar Wiese and Michael Dalager-Pedersen and Steffen Leth and Mortensen, {Preben Bo} and Anne-Mette Lebech and Niels Obel and Omland, {Lars H}",

note = "{\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: [email protected].",

year = "2023",

month = dec,

doi = "10.1093/cid/ciad415",

language = "English",

volume = "77",

pages = "1569--1577",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "11",

}

Vollmond, CV, Tetens, MM, Paulsen, FW, Gerstoft, J, Kronborg, G, Johansen, IS, Larsen, CS, Wiese, L, Dalager-Pedersen, M, Leth, S , Mortensen, PB, Lebech, A-M, Obel, N & Omland, LH 2023, 'Risk of Depression in People With Human Immunodeficiency Virus: A nationwide population-based matched cohort study', Clinical Infectious Diseases, bind 77, nr. 11, s. 1569-1577. https://doi.org/10.1093/cid/ciad415

Risk of Depression in People With Human Immunodeficiency Virus: A nationwide population-based matched cohort study. / Vollmond, Cecilie V; Tetens, Malte M; Paulsen, Fie W et al.
I: Clinical Infectious Diseases, Bind 77, Nr. 11, 12.2023, s. 1569-1577.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Risk of Depression in People With Human Immunodeficiency Virus

T2 - A nationwide population-based matched cohort study

AU - Vollmond, Cecilie V

AU - Tetens, Malte M

AU - Paulsen, Fie W

AU - Gerstoft, Jan

AU - Kronborg, Gitte

AU - Johansen, Isik S

AU - Larsen, Carsten S

AU - Wiese, Lothar

AU - Dalager-Pedersen, Michael

AU - Leth, Steffen

AU - Mortensen, Preben Bo

AU - Lebech, Anne-Mette

AU - Obel, Niels

AU - Omland, Lars H

PY - 2023/12

Y1 - 2023/12

N2 - BACKGROUND: HIV infection is associated with depression, but previous studies are imprecise and have not addressed familial factors.METHODS: Nationwide, population-based matched cohort study of people with HIV (PWH) in Denmark between 1995 and 2021, matched on sex and date of birth with a comparison cohort randomly selected from the Danish population. Aditionally, family related factors were examined by inclusion of siblings of these cohorts. We calculated hazard ratios (HR) for depression, receipt of antidepressants, electroconvulsive therapy (ECT), and suicide and yearly proportions of study cohorts with psychiatric hospital contact due to depression and receipt of antidepressants from 10 years before to 10 years after study inclusion.RESULTS: We included 5,943 PWH and 59,430 comparison cohort members. Median age was 38 years and 25% were women. We observed an increased risk of depression, receipt of antidepressants, ECT, and suicide among PWH in the 2 first years of observation (HR of 3.3 (95% CI: 2.5-4.4), 3.0 (95% CI: 2.7-3.4), 2.8 (95% CI: 0.9-8.6) and 10.7 (95% CI: 5.2-22.2)), thereafter the risk subsided, but remained increased. The proportions of PWH with psychiatric hospital contact due to depression and receipt of antidepressants were increased prior to-, and especially after HIV diagnosis. Risk of all outcomes were substantially lower among siblings of PWH than among PWH (HR for receipt of antidepressants was 1.1 (95% CI: 1.0-1.2)).CONCLUSION: PWH have an increased risk of depression, especially in the first 2 years after HIV diagnosis. Family related factors are unlikely to explain this risk.

AB - BACKGROUND: HIV infection is associated with depression, but previous studies are imprecise and have not addressed familial factors.METHODS: Nationwide, population-based matched cohort study of people with HIV (PWH) in Denmark between 1995 and 2021, matched on sex and date of birth with a comparison cohort randomly selected from the Danish population. Aditionally, family related factors were examined by inclusion of siblings of these cohorts. We calculated hazard ratios (HR) for depression, receipt of antidepressants, electroconvulsive therapy (ECT), and suicide and yearly proportions of study cohorts with psychiatric hospital contact due to depression and receipt of antidepressants from 10 years before to 10 years after study inclusion.RESULTS: We included 5,943 PWH and 59,430 comparison cohort members. Median age was 38 years and 25% were women. We observed an increased risk of depression, receipt of antidepressants, ECT, and suicide among PWH in the 2 first years of observation (HR of 3.3 (95% CI: 2.5-4.4), 3.0 (95% CI: 2.7-3.4), 2.8 (95% CI: 0.9-8.6) and 10.7 (95% CI: 5.2-22.2)), thereafter the risk subsided, but remained increased. The proportions of PWH with psychiatric hospital contact due to depression and receipt of antidepressants were increased prior to-, and especially after HIV diagnosis. Risk of all outcomes were substantially lower among siblings of PWH than among PWH (HR for receipt of antidepressants was 1.1 (95% CI: 1.0-1.2)).CONCLUSION: PWH have an increased risk of depression, especially in the first 2 years after HIV diagnosis. Family related factors are unlikely to explain this risk.

KW - PWH

KW - antidepressants

KW - depression

KW - Humans

KW - Risk Factors

KW - Male

KW - Depression/epidemiology

KW - HIV

KW - HIV Infections/complications

KW - Adult

KW - Antidepressive Agents/therapeutic use

KW - Female

KW - Cohort Studies

UR - http://www.scopus.com/inward/record.url?scp=85178496111&partnerID=8YFLogxK

U2 - 10.1093/cid/ciad415

DO - 10.1093/cid/ciad415

M3 - Journal article

C2 - 37467149

SN - 1058-4838

VL - 77

SP - 1569

EP - 1577

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 11

ER -

Risk of Depression in People With Human Immunodeficiency Virus: A nationwide population-based matched cohort study

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