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Risk factors for pneumococcal nasopharyngeal colonization before and after pneumococcal conjugate vaccination in persons with HIV: brief report

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Risk factors for pneumococcal nasopharyngeal colonization before and after pneumococcal conjugate vaccination in persons with HIV : brief report. / Öbrink-Hansen, Kristina; Søgaard, Ole S; Harboe, Zitta B; Schønheyder, Henrik C.

I: Current H I V Research, Bind 10, Nr. 3, 2012, s. 252-5.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{81e1364d55f44618b77e186a5413b6f0,
title = "Risk factors for pneumococcal nasopharyngeal colonization before and after pneumococcal conjugate vaccination in persons with HIV: brief report",
abstract = "HIV-infected individuals have excess rates of invasive pneumococcal disease. We investigated risk factors for nasopharyngeal pneumococcal colonization at baseline and after 9 months in 96 HIV patients immunized twice with 7- valent pneumococcal conjugate vaccine ±1mg CPG 7909. In total, 22 patients (23%) were colonized, 11 at baseline only, four at both baseline and 9 months, and seven at 9 months only. Compared to non-colonized patients, more colonized patients were smokers, had lower CD4+ nadir and had an AIDS-diagnosis. Immunization, antiretroviral treatment and the CPG adjuvant had no impact on colonization. These results suggest preventive strategies in addition to pneumococcal immunization.",
keywords = "AIDS-Related Opportunistic Infections, CD4-Positive T-Lymphocytes, Clinical Trials, Phase I as Topic, Clinical Trials, Phase II as Topic, Cohort Studies, Colony Count, Microbial, Female, Follow-Up Studies, Humans, Male, Middle Aged, Nasopharynx, Pneumococcal Infections, Pneumococcal Vaccines, Randomized Controlled Trials as Topic, Risk Factors, Smoking, Streptococcus pneumoniae, Vaccines, Conjugate",
author = "Kristina {\"O}brink-Hansen and S{\o}gaard, {Ole S} and Harboe, {Zitta B} and Sch{\o}nheyder, {Henrik C}",
year = "2012",
language = "English",
volume = "10",
pages = "252--5",
journal = "Current H I V Research",
issn = "1570-162X",
publisher = "Bentham Science Publishers Ltd.",
number = "3",

}

RIS

TY - JOUR

T1 - Risk factors for pneumococcal nasopharyngeal colonization before and after pneumococcal conjugate vaccination in persons with HIV

T2 - brief report

AU - Öbrink-Hansen, Kristina

AU - Søgaard, Ole S

AU - Harboe, Zitta B

AU - Schønheyder, Henrik C

PY - 2012

Y1 - 2012

N2 - HIV-infected individuals have excess rates of invasive pneumococcal disease. We investigated risk factors for nasopharyngeal pneumococcal colonization at baseline and after 9 months in 96 HIV patients immunized twice with 7- valent pneumococcal conjugate vaccine ±1mg CPG 7909. In total, 22 patients (23%) were colonized, 11 at baseline only, four at both baseline and 9 months, and seven at 9 months only. Compared to non-colonized patients, more colonized patients were smokers, had lower CD4+ nadir and had an AIDS-diagnosis. Immunization, antiretroviral treatment and the CPG adjuvant had no impact on colonization. These results suggest preventive strategies in addition to pneumococcal immunization.

AB - HIV-infected individuals have excess rates of invasive pneumococcal disease. We investigated risk factors for nasopharyngeal pneumococcal colonization at baseline and after 9 months in 96 HIV patients immunized twice with 7- valent pneumococcal conjugate vaccine ±1mg CPG 7909. In total, 22 patients (23%) were colonized, 11 at baseline only, four at both baseline and 9 months, and seven at 9 months only. Compared to non-colonized patients, more colonized patients were smokers, had lower CD4+ nadir and had an AIDS-diagnosis. Immunization, antiretroviral treatment and the CPG adjuvant had no impact on colonization. These results suggest preventive strategies in addition to pneumococcal immunization.

KW - AIDS-Related Opportunistic Infections

KW - CD4-Positive T-Lymphocytes

KW - Clinical Trials, Phase I as Topic

KW - Clinical Trials, Phase II as Topic

KW - Cohort Studies

KW - Colony Count, Microbial

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Nasopharynx

KW - Pneumococcal Infections

KW - Pneumococcal Vaccines

KW - Randomized Controlled Trials as Topic

KW - Risk Factors

KW - Smoking

KW - Streptococcus pneumoniae

KW - Vaccines, Conjugate

M3 - Journal article

C2 - 22384845

VL - 10

SP - 252

EP - 255

JO - Current H I V Research

JF - Current H I V Research

SN - 1570-162X

IS - 3

ER -