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Revisiting the global workspace orchestrating the hierarchical organization of the human brain

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Revisiting the global workspace orchestrating the hierarchical organization of the human brain. / Deco, Gustavo; Vidaurre Henche, Diego; Kringelbach, Morten L.

I: Nature Human Behaviour, Bind 5, Nr. 4, 04.2021, s. 497-511.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{b61bdd020f0c4349a8f501b56b9230f4,
title = "Revisiting the global workspace orchestrating the hierarchical organization of the human brain",
abstract = "A central challenge in neuroscience is how the brain organizes the information necessary to orchestrate behaviour. Arguably, this whole-brain orchestration is carried out by a core subset of integrative brain regions, a {\textquoteleft}global workspace{\textquoteright}, but its constitutive regions remain unclear. We quantified the global workspace as the common regions across seven tasks as well as rest, in a common {\textquoteleft}functional rich club{\textquoteright}. To identify this functional rich club, we determined the information flow between brain regions by means of a normalized directed transfer entropy framework applied to multimodal neuroimaging data from 1,003 healthy participants and validated in participants with retest data. This revealed a set of regions orchestrating information from perceptual, long-term memory, evaluative and attentional systems. We confirmed the causal significance and robustness of our results by systematically lesioning a generative whole-brain model. Overall, this framework describes a complex choreography of the functional hierarchical organization of the human brain.",
keywords = "CINGULATE CORTEX, CONNECTOME, FUNCTIONAL CONNECTIVITY, HUMAN CEREBRAL-CORTEX, MYELIN CONTENT, NETWORK, NEURONAL MODEL, ORBITOFRONTAL CORTEX, STATE, TRANSFER ENTROPY",
author = "Gustavo Deco and {Vidaurre Henche}, Diego and Kringelbach, {Morten L.}",
year = "2021",
month = apr,
doi = "10.1038/s41562-020-01003-6",
language = "English",
volume = "5",
pages = "497--511",
journal = "Nature Human Behavior",
issn = "2397-3374",
publisher = "Springer Nature",
number = "4",

}

RIS

TY - JOUR

T1 - Revisiting the global workspace orchestrating the hierarchical organization of the human brain

AU - Deco, Gustavo

AU - Vidaurre Henche, Diego

AU - Kringelbach, Morten L.

PY - 2021/4

Y1 - 2021/4

N2 - A central challenge in neuroscience is how the brain organizes the information necessary to orchestrate behaviour. Arguably, this whole-brain orchestration is carried out by a core subset of integrative brain regions, a ‘global workspace’, but its constitutive regions remain unclear. We quantified the global workspace as the common regions across seven tasks as well as rest, in a common ‘functional rich club’. To identify this functional rich club, we determined the information flow between brain regions by means of a normalized directed transfer entropy framework applied to multimodal neuroimaging data from 1,003 healthy participants and validated in participants with retest data. This revealed a set of regions orchestrating information from perceptual, long-term memory, evaluative and attentional systems. We confirmed the causal significance and robustness of our results by systematically lesioning a generative whole-brain model. Overall, this framework describes a complex choreography of the functional hierarchical organization of the human brain.

AB - A central challenge in neuroscience is how the brain organizes the information necessary to orchestrate behaviour. Arguably, this whole-brain orchestration is carried out by a core subset of integrative brain regions, a ‘global workspace’, but its constitutive regions remain unclear. We quantified the global workspace as the common regions across seven tasks as well as rest, in a common ‘functional rich club’. To identify this functional rich club, we determined the information flow between brain regions by means of a normalized directed transfer entropy framework applied to multimodal neuroimaging data from 1,003 healthy participants and validated in participants with retest data. This revealed a set of regions orchestrating information from perceptual, long-term memory, evaluative and attentional systems. We confirmed the causal significance and robustness of our results by systematically lesioning a generative whole-brain model. Overall, this framework describes a complex choreography of the functional hierarchical organization of the human brain.

KW - CINGULATE CORTEX

KW - CONNECTOME

KW - FUNCTIONAL CONNECTIVITY

KW - HUMAN CEREBRAL-CORTEX

KW - MYELIN CONTENT

KW - NETWORK

KW - NEURONAL MODEL

KW - ORBITOFRONTAL CORTEX

KW - STATE

KW - TRANSFER ENTROPY

UR - http://www.scopus.com/inward/record.url?scp=85098778793&partnerID=8YFLogxK

U2 - 10.1038/s41562-020-01003-6

DO - 10.1038/s41562-020-01003-6

M3 - Journal article

C2 - 33398141

AN - SCOPUS:85098778793

VL - 5

SP - 497

EP - 511

JO - Nature Human Behavior

JF - Nature Human Behavior

SN - 2397-3374

IS - 4

ER -