Reversible activation of pH-sensitive cell penetrating peptides attached to gold surfaces

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DOI

  • Joe E. Baio, Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
  • ,
  • Denise K Schach, Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
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  • Adrian V Fuchs, Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
  • ,
  • Lars Schmüser, Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
  • ,
  • Nils Billecke, Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
  • ,
  • Christoph Bubeck, Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
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  • Katharina Landfester, Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
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  • Mischa Bonn, Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
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  • Michael Bruns, Karlsruhe Institute of Technology, Institute for Applied Materials and Karlsruhe Nano Micro Facility, 76344 Eggenstein-Leopoldshafen, Germany.
  • ,
  • Clemens K Weiss, Max Planck Institute for Polymer Research, 55270 Mainz, Germany., University of Applied Sciences Bingen, 55411 Bingen, Germany
  • ,
  • Tobias Weidner

pH-sensitive viral fusion protein mimics are widely touted as a promising route towards site-specific delivery of therapeutic compounds across lipid membranes. Here, we demonstrate that a fusion protein mimic, designed to achieve a reversible, pH-driven helix-coil transition mechanism, retains its functionality when covalently bound to a surface.

OriginalsprogEngelsk
TidsskriftChemical Communications
Vol/bind51
Nummer2
Sider (fra-til)273-275
Antal sider3
ISSN1359-7345
DOI
StatusUdgivet - 2015
Eksternt udgivetJa

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