Return to Work After Refractory Out-of-Hospital Cardiac Arrest in Patients Managed With or Without Extracorporeal Cardiopulmonary Resuscitation: A Nationwide Register-Based Study

Emilie Gregers; Kristian Kragholm; Louise Linde; Sivagowry Rasalingam Mørk; Jo Bønding Andreasen; Christian Juhl Terkelsen; Jens Flensted Lassen; Jacob Eifer Møller; Helle Laugesen; Morten Smerup; Jesper Kjærgaard; Peter Hasse Møller-Sørensen; Lene Holmvang; Christian Torp-Pedersen; Christian Hassager; Helle Søholm

doi:10.1161/JAHA.123.034024

Return to Work After Refractory Out-of-Hospital Cardiac Arrest in Patients Managed With or Without Extracorporeal Cardiopulmonary Resuscitation: A Nationwide Register-Based Study

Emilie Gregers, Kristian Kragholm, Louise Linde, Sivagowry Rasalingam Mørk, Jo Bønding Andreasen, Christian Juhl Terkelsen, Jens Flensted Lassen, Jacob Eifer Møller, Helle Laugesen, Morten Smerup, Jesper Kjærgaard, Peter Hasse Møller-Sørensen, Lene Holmvang, Christian Torp-Pedersen, Christian Hassager, Helle Søholm

Institut for Klinisk Medicin - Hjertesygdomme

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

BACKGROUND: Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used for refractory out-of-hospital cardiac arrest (OHCA). However, survivors managed with ECPR are at risk of poor functional status. The purpose of this study was to investigate return to work (RTW) after refractory OHCA.

METHODS AND RESULTS: Of 44 360 patients with OHCA in the period of 2011 to 2020, this nationwide registry-based study included 805 patients with refractory OHCA in the working age (18-65 years) who were employed before OHCA (2% of the total OHCA cohort). Demographics, prehospital characteristics, status at hospital arrival, employment status, and survival were retrieved through the Danish national registries. Sustainable RTW was defined as RTW for ≥6 months without any long sick leave relapses. Median follow-up time was 4.1 years. ECPR and standard advanced cardiovascular life support were applied in 136 and 669 patients, respectively. RTW 1 year after OHCA was similar (39% versus 54%; P=0.2) and sustainable RTW was high in both survivors managed with ECPR and survivors managed with standard advanced cardiovascular life support (83% versus 85%; P>0.9). Younger age and shorter length of hospitalization were associated with RTW in multivariable Cox analysis, whereas ECPR was not.

CONCLUSIONS: In refractory OHCA-patients employed prior to OHCA, approximately 1 out of 2 patients were employed after 1 year with no difference between patients treated with ECPR or standard advanced cardiovascular life support. Younger age and shorter length of hospitalization were associated with RTW while ECPR was not.

Originalsprog	Engelsk
Artikelnummer	e034024
Tidsskrift	Journal of the American Heart Association
Vol/bind	13
Nummer	7
Sider (fra-til)	e034024
ISSN	2047-9980
DOI	https://doi.org/10.1161/JAHA.123.034024
Status	Udgivet - apr. 2024

Adgang til dokumentet

10.1161/JAHA.123.034024Licens: CC BY-NC-ND

Citationsformater

Gregers, E., Kragholm, K., Linde, L., Mørk, S. R., Andreasen, J. B., Terkelsen, C. J., Lassen, J. F., Møller, J. E., Laugesen, H., Smerup, M., Kjærgaard, J., Møller-Sørensen, P. H., Holmvang, L., Torp-Pedersen, C., Hassager, C., & Søholm, H. (2024). Return to Work After Refractory Out-of-Hospital Cardiac Arrest in Patients Managed With or Without Extracorporeal Cardiopulmonary Resuscitation: A Nationwide Register-Based Study. Journal of the American Heart Association, 13(7), e034024. Artikel e034024. https://doi.org/10.1161/JAHA.123.034024

@article{46df546ab9a8480d924eaad6e4eb8f3b,

title = "Return to Work After Refractory Out-of-Hospital Cardiac Arrest in Patients Managed With or Without Extracorporeal Cardiopulmonary Resuscitation: A Nationwide Register-Based Study",

abstract = "BACKGROUND: Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used for refractory out-of-hospital cardiac arrest (OHCA). However, survivors managed with ECPR are at risk of poor functional status. The purpose of this study was to investigate return to work (RTW) after refractory OHCA.METHODS AND RESULTS: Of 44 360 patients with OHCA in the period of 2011 to 2020, this nationwide registry-based study included 805 patients with refractory OHCA in the working age (18-65 years) who were employed before OHCA (2% of the total OHCA cohort). Demographics, prehospital characteristics, status at hospital arrival, employment status, and survival were retrieved through the Danish national registries. Sustainable RTW was defined as RTW for ≥6 months without any long sick leave relapses. Median follow-up time was 4.1 years. ECPR and standard advanced cardiovascular life support were applied in 136 and 669 patients, respectively. RTW 1 year after OHCA was similar (39% versus 54%; P=0.2) and sustainable RTW was high in both survivors managed with ECPR and survivors managed with standard advanced cardiovascular life support (83% versus 85%; P>0.9). Younger age and shorter length of hospitalization were associated with RTW in multivariable Cox analysis, whereas ECPR was not.CONCLUSIONS: In refractory OHCA-patients employed prior to OHCA, approximately 1 out of 2 patients were employed after 1 year with no difference between patients treated with ECPR or standard advanced cardiovascular life support. Younger age and shorter length of hospitalization were associated with RTW while ECPR was not.",

keywords = "extracorporeal cardiopulmonary resuscitation, out‐of‐hospital cardiac arrest, return to work, Humans, Middle Aged, Cardiopulmonary Resuscitation/methods, Out-of-Hospital Cardiac Arrest/therapy, Return to Work, Young Adult, Extracorporeal Membrane Oxygenation, Hospitals, Adolescent, Adult, Aged, Retrospective Studies",

author = "Emilie Gregers and Kristian Kragholm and Louise Linde and M{\o}rk, {Sivagowry Rasalingam} and Andreasen, {Jo B{\o}nding} and Terkelsen, {Christian Juhl} and Lassen, {Jens Flensted} and M{\o}ller, {Jacob Eifer} and Helle Laugesen and Morten Smerup and Jesper Kj{\ae}rgaard and M{\o}ller-S{\o}rensen, {Peter Hasse} and Lene Holmvang and Christian Torp-Pedersen and Christian Hassager and Helle S{\o}holm",

year = "2024",

month = apr,

doi = "10.1161/JAHA.123.034024",

language = "English",

volume = "13",

pages = "e034024",

journal = "Journal of the American Heart Association",

issn = "2047-9980",

publisher = "Wiley-Blackwell Publishing, Inc.",

number = "7",

}

Gregers, E, Kragholm, K, Linde, L, Mørk, SR, Andreasen, JB, Terkelsen, CJ, Lassen, JF, Møller, JE, Laugesen, H, Smerup, M, Kjærgaard, J, Møller-Sørensen, PH, Holmvang, L, Torp-Pedersen, C, Hassager, C & Søholm, H 2024, 'Return to Work After Refractory Out-of-Hospital Cardiac Arrest in Patients Managed With or Without Extracorporeal Cardiopulmonary Resuscitation: A Nationwide Register-Based Study', Journal of the American Heart Association, bind 13, nr. 7, e034024, s. e034024. https://doi.org/10.1161/JAHA.123.034024

Return to Work After Refractory Out-of-Hospital Cardiac Arrest in Patients Managed With or Without Extracorporeal Cardiopulmonary Resuscitation: A Nationwide Register-Based Study. / Gregers, Emilie; Kragholm, Kristian; Linde, Louise et al.
I: Journal of the American Heart Association, Bind 13, Nr. 7, e034024, 04.2024, s. e034024.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Return to Work After Refractory Out-of-Hospital Cardiac Arrest in Patients Managed With or Without Extracorporeal Cardiopulmonary Resuscitation

T2 - A Nationwide Register-Based Study

AU - Gregers, Emilie

AU - Kragholm, Kristian

AU - Linde, Louise

AU - Mørk, Sivagowry Rasalingam

AU - Andreasen, Jo Bønding

AU - Terkelsen, Christian Juhl

AU - Lassen, Jens Flensted

AU - Møller, Jacob Eifer

AU - Laugesen, Helle

AU - Smerup, Morten

AU - Kjærgaard, Jesper

AU - Møller-Sørensen, Peter Hasse

AU - Holmvang, Lene

AU - Torp-Pedersen, Christian

AU - Hassager, Christian

AU - Søholm, Helle

PY - 2024/4

Y1 - 2024/4

N2 - BACKGROUND: Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used for refractory out-of-hospital cardiac arrest (OHCA). However, survivors managed with ECPR are at risk of poor functional status. The purpose of this study was to investigate return to work (RTW) after refractory OHCA.METHODS AND RESULTS: Of 44 360 patients with OHCA in the period of 2011 to 2020, this nationwide registry-based study included 805 patients with refractory OHCA in the working age (18-65 years) who were employed before OHCA (2% of the total OHCA cohort). Demographics, prehospital characteristics, status at hospital arrival, employment status, and survival were retrieved through the Danish national registries. Sustainable RTW was defined as RTW for ≥6 months without any long sick leave relapses. Median follow-up time was 4.1 years. ECPR and standard advanced cardiovascular life support were applied in 136 and 669 patients, respectively. RTW 1 year after OHCA was similar (39% versus 54%; P=0.2) and sustainable RTW was high in both survivors managed with ECPR and survivors managed with standard advanced cardiovascular life support (83% versus 85%; P>0.9). Younger age and shorter length of hospitalization were associated with RTW in multivariable Cox analysis, whereas ECPR was not.CONCLUSIONS: In refractory OHCA-patients employed prior to OHCA, approximately 1 out of 2 patients were employed after 1 year with no difference between patients treated with ECPR or standard advanced cardiovascular life support. Younger age and shorter length of hospitalization were associated with RTW while ECPR was not.

AB - BACKGROUND: Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used for refractory out-of-hospital cardiac arrest (OHCA). However, survivors managed with ECPR are at risk of poor functional status. The purpose of this study was to investigate return to work (RTW) after refractory OHCA.METHODS AND RESULTS: Of 44 360 patients with OHCA in the period of 2011 to 2020, this nationwide registry-based study included 805 patients with refractory OHCA in the working age (18-65 years) who were employed before OHCA (2% of the total OHCA cohort). Demographics, prehospital characteristics, status at hospital arrival, employment status, and survival were retrieved through the Danish national registries. Sustainable RTW was defined as RTW for ≥6 months without any long sick leave relapses. Median follow-up time was 4.1 years. ECPR and standard advanced cardiovascular life support were applied in 136 and 669 patients, respectively. RTW 1 year after OHCA was similar (39% versus 54%; P=0.2) and sustainable RTW was high in both survivors managed with ECPR and survivors managed with standard advanced cardiovascular life support (83% versus 85%; P>0.9). Younger age and shorter length of hospitalization were associated with RTW in multivariable Cox analysis, whereas ECPR was not.CONCLUSIONS: In refractory OHCA-patients employed prior to OHCA, approximately 1 out of 2 patients were employed after 1 year with no difference between patients treated with ECPR or standard advanced cardiovascular life support. Younger age and shorter length of hospitalization were associated with RTW while ECPR was not.

KW - extracorporeal cardiopulmonary resuscitation

KW - out‐of‐hospital cardiac arrest

KW - return to work

KW - Humans

KW - Middle Aged

KW - Cardiopulmonary Resuscitation/methods

KW - Out-of-Hospital Cardiac Arrest/therapy

KW - Return to Work

KW - Young Adult

KW - Extracorporeal Membrane Oxygenation

KW - Hospitals

KW - Adolescent

KW - Adult

KW - Aged

KW - Retrospective Studies

U2 - 10.1161/JAHA.123.034024

DO - 10.1161/JAHA.123.034024

M3 - Journal article

C2 - 38533974

SN - 2047-9980

VL - 13

SP - e034024

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

IS - 7

M1 - e034024

ER -

Gregers E, Kragholm K, Linde L, Mørk SR, Andreasen JB, Terkelsen CJ et al. Return to Work After Refractory Out-of-Hospital Cardiac Arrest in Patients Managed With or Without Extracorporeal Cardiopulmonary Resuscitation: A Nationwide Register-Based Study. Journal of the American Heart Association. 2024 apr.;13(7):e034024. e034024. Epub 2024 mar. 27. doi: 10.1161/JAHA.123.034024

Return to Work After Refractory Out-of-Hospital Cardiac Arrest in Patients Managed With or Without Extracorporeal Cardiopulmonary Resuscitation: A Nationwide Register-Based Study

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater